HIV-1 Envelope (ENV) GP160 Trimer Protein Complex SPIKE as a Recombinant Macromolecular Assembly Vaccine Component Candidate: Current Opinion

Nilofer, Christina; Arumugam, Mohanapriya; Kangueane, Pandjassarame

doi:10.1007/978-1-4939-7290-6_36

Global Virology II - HIV and NeuroAIDS 2017

DOI: 10.1007/978-1-4939-7290-6_36

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HIV-1 Envelope (ENV) GP160 Trimer Protein Complex SPIKE as a Recombinant Macromolecular Assembly Vaccine Component Candidate: Current Opinion

Christina Nilofer¹,

Mohanapriya Arumugam

Pandjassarame Kangueane³

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2020

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Cited by 2 publications

(1 citation statement)

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“…Preparation of ligands, protein files and grid/docking parameters were done according to our previous reports(Almalki et al 2019;Gouda and Almalki 2019). Discovery Studio Visualizer(Nilofer et al 2017) was used to visualize the 2/3D binding modes/interactions of the five lactones.…”

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confidence: 99%

Docking studies of sesquiterpene lactones isolated from Ambrosia maritima L. reveals their potential anti-inflammatory and cytotoxic activities

Mohamed

Hassan

Gouda

et al. 2020

Natural Product Research

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Five sesquiterpene lactones were isolated and identified from Ambrosia maritima L.. Hymenin showed highest cytotoxic activity against HCT-116, A-549 and MCF-7 cell lines (IC 50= 3.83 ± 0.2, 5.48 ± 0.3, 10.1 ±0.6 µg/ml respectively). Damsin has significant COX-2 inhibitory activity (IC 50 33.97 ± 1.62 µg/ml) while hymenin showed highest selectivity to COX-1 (IC 50 = 18.21 µg/ml) and significant inhibition of NO (IC 50 18.19 ± 0.75 µg/ml). From docking study, maritimolide showed higher affinity towards human Src kinase than the native ligand, Bosutinib. Results suggested that both COXs/ Src kinase inhibition could contribute even partially to the overall mechanism of cytotoxic activity of the five compounds. The structure activity relationship revealed that α-methylene-γ-lactone moiety enhances the activity against tested cell lines, OH group at C-1 increase activity of hymenin. However; the reduction of the double bond at C-2 as in damsin resulted in significant decrease in activity against HCT-116 and MCF-7 cells.

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confidence: 99%

Docking studies of sesquiterpene lactones isolated from Ambrosia maritima L. reveals their potential anti-inflammatory and cytotoxic activities

Mohamed

Hassan

Gouda

et al. 2020

Natural Product Research

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Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity

Gomaa

El-Sherief

Hussein

et al. 2020

Bioorganic Chemistry

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HIV-1 Envelope (ENV) GP160 Trimer Protein Complex SPIKE as a Recombinant Macromolecular Assembly Vaccine Component Candidate: Current Opinion

Cited by 2 publications

References 24 publications

Docking studies of sesquiterpene lactones isolated from Ambrosia maritima L. reveals their potential anti-inflammatory and cytotoxic activities

Docking studies of sesquiterpene lactones isolated from Ambrosia maritima L. reveals their potential anti-inflammatory and cytotoxic activities

Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity

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