HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation of the intrinsic immunity factor

Goffinet, Christine; Allespach, Ina; Homann, Stefanie; Tervo, Hanna-Mari; Habermann, Anja; Rupp, Daniel; Oberbremer, Lena; Kern, Christian; Tibroni, Nadine; Welsch, Sonja; Krijnse‐Locker, Jacomine; Banting, George; Kräusslich, Hans‐Georg; Fackler, Oliver T.; Keppler, Oliver T.

doi:10.1186/1742-4690-6-s2-o10

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“…Additional viral antagonists of tetherin include the KSHV K5 protein and the glycoproteins of SIV, FIV, and Ebola virus (2,4,16,31,32). The activities of these viral proteins as tetherin antagonists are species specific (51,52). The mechanism by which HIV-1 Vpu counteracts human tetherin has been extensively studied.…”

Section: Discussionmentioning

confidence: 99%

Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein

Yin

et al. 2014

J Virol

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Human tetherin is a host restriction factor that inhibits replication of enveloped viruses by blocking viral release. Tetherin has an unusual topology that includes an N-terminal cytoplasmic tail, a single transmembrane domain, an extracellular domain, and a C-terminal glycosylphosphatidylinositol anchor. Tetherin is not well conserved across species, so it inhibits viral replication in a species-specific manner. Thus, studies of tetherin activities from different species provide an important tool for understanding its antiviral mechanism. Here, we report cloning of equine tetherin and characterization of its antiviral activity. Equine tetherin shares 53%, 40%, 36%, and 34% amino acid sequence identity with feline, human, simian, and murine tetherins, respectively. Like the feline tetherin, equine tetherin has a shorter N-terminal domain than human tetherin. Equine tetherin is localized on the cell surface and strongly blocks human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV) release from virus-producing cells. The antiviral activity of equine tetherin is neutralized by EIAV envelope protein, but not by the HIV-1 accessory protein Vpu, which is a human tetherin antagonist, and EIAV envelope protein does not counteract human tetherin. These results shed new light on our understanding of the species-specific tetherin antiviral mechanism.

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Section: Discussionmentioning

confidence: 99%

Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein

Yin

et al. 2014

J Virol

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show abstract

HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation of the intrinsic immunity factor

Cited by 1 publication

References 0 publications

Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein

Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein

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