HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
Alex Kleinpeter,
Donna L. Mallery,
Nadine Renner
et al.
Abstract:The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created by CA Arg-18 (R18) and Lys-25 (K25). Here we describe the forced evolution of viruses containing mutations in R18 and K25. Whilst R18 mutants fail to replicate, K25A viruses acquire compensating mutations that restore nearl… Show more
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