Abstract:In contrast to the canonical picture of transport by direct attachment to motor proteins, recent evidence shows that a number of intracellular 'cargos' navigate the cytoplasm by hitchhiking on motor-driven 'carrier' organelles. We describe a quantitative model of intracellular cargo transport via hitchhiking, examining the efficiency of hitchhiking initiation as a function of geometric and mechanical parameters. We focus specifically on the parameter regime relevant to the hitchhiking motion of peroxisome orga… Show more
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