History of uses, phytochemistry, pharmacological activities, quality control and toxicity of the root of Stephania tetrandra S. Moore: A review

Zhang, Yuelin; Qi, Dongli; Gao, Yanquan; Liang, Chun-Xia; Zhang, Yukun; Ma, Zhe; Liu, Yiting; Peng, Hong-Li; Zhang, Ying; Qin, Huan; Song, Xunan; Sun, Xinru; Li, Yingpeng; Liu, Zhidong

doi:10.1016/j.jep.2020.112995

Cited by 27 publications

(21 citation statements)

References 37 publications

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“…( 4) Patients can accept CT scan examination, no contraindications to contrast agent allergy. ( 5 The expelling wind and relieving cough and asthma prescription of this study refers to the equation of Zhang et al [13], and it is slightly modified. The expelling wind and relieving cough and asthma prescription of this study included: ephedra + 10 g, bitter almond + 10 g, Scutellaria b aicalensis + 12 g, rhizoma pinelliae + 10 g, periostracum cicadae + 10 g, baked radix glycyrrhizae + 8 g, Cortex Mori + 9 g, perilla seed + 9 g, Platycodon grandif lorum + 6 g, and ground dragon + 12 g.…”

Section: Introductionmentioning

confidence: 99%

Intelligent Enhancement Algorithm-Based High Resolution CT Image in Evaluation of Expelling Wind and Relieving Cough and Asthma Prescription on Bronchial Asthma with High Immunoglobulin E Expression

Shen

Chen

2022

Computational and Mathematical Methods in Medicine

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The therapeutic effect of expelling wind and relieving cough and asthma prescription on bronchial asthma with high immunoglobulin E (IgE) expression was studied based on high resolution CT (HRCT) images of intelligent enhancement algorithm. 90 patients with bronchial asthma were randomly divided into control group ( n = 45 ) and therapy group ( n = 45 ). The control group was given budesonide inhalation. The therapy group was treated with expelling wind and relieving cough and asthma prescription on the basis of the treatment in the control group. Both groups were given 1 month of treatment time. The scanned images were processed by image enhancement algorithm, and the image quality and distribution separation measurement (DSM) were used as image evaluation indicators. The bronchial wall thickness (WT), inner diameter (L), wall area (WA), and percentage of wall area (WA%) were used as quantitative indicators of airway remodeling. The changes of traditional Chinese medicine (TCM) score before and after treatment were recorded and analyzed. The changes of serum IgE indicators before and after treatment were recorded. Results: the image quality of HRCT image enhancement algorithm was better, and the DSM was 36.7 larger than that of the control group. It was found that after 1 month of treatment, the TCM symptom score of the therapy group was lower than that of the control group ( P < 0.05 ), and compared with the control group, the IgE level of the therapy group was also reduced. Meanwhile, compared with the control group, the WT of segmental bronchial wall in the therapy group decreased, and the WT of left apical bronchus was smaller than that in the control group ( P < 0.05 ), and the WT of subsegmental bronchus decreased significantly ( P < 0.05 ). The L of segmental bronchus and subsegmental bronchus in the therapy group was wider ( P < 0.05 ). The WA of segmental bronchus and subsegmental bronchus decreased, but there was no statistical significance ( P > 0.05 ). Compared with the control group, the WA percentage of segmental bronchus and the WA percentage of subsegmental bronchus in the therapy group were significantly lower ( P < 0.05 ). In conclusion, image enhancement algorithm can improve the HRCT image quality of patients with bronchial asthma, which is helpful to improve the diagnostic efficiency in clinical treatment. Expelling wind and relieving cough and asthma prescription has a better therapeutic effect on bronchial asthma with high IgE expression.

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Section: Introductionmentioning

confidence: 99%

Intelligent Enhancement Algorithm-Based High Resolution CT Image in Evaluation of Expelling Wind and Relieving Cough and Asthma Prescription on Bronchial Asthma with High Immunoglobulin E Expression

Shen

Chen

2022

Computational and Mathematical Methods in Medicine

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“…While a variety of herbal treatments are available depending on symptoms, the treatment of inflammation using medicinal plants and phytochemicals is considerably similar to the treatment prescribed for leaky gut syndrome. Stephania tetrandra S.Moore alkaloids (tetrandrine and fangchinoline, among others), flavonoids (stephaflavone A, stephaflavone B), steroids (β-sitosterol, β-stigmasterol) [111] Benincasa his pida(Thunb. )Cogn triterpenes (alnusenol, multiflorenol, isomultiflorenol), sterols (lupeol, lupeol acetate, β-sitosterol), glycosides, saccharides, caretenes, β-sitosterin, tannins and uronic acid [112] Astragalus membranaceus (Fisch.)…”

Section: Medicinal Plants For Treating Phlegm Syndromementioning

confidence: 99%

The Interrelationships between Intestinal Permeability and Phlegm Syndrome and Therapeutic Potential of Some Medicinal Herbs

Park

Choi²,

Kang

et al. 2021

Biomolecules

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The gastrointestinal (GI) tract has an intriguing and critical role beyond digestion in both modern and complementary and alternative medicine (CAM), as demonstrated by its link with the immune system. In this review, we attempted to explore the interrelationships between increased GI permeability and phlegm, an important pathological factor in CAM, syndrome, and therapeutic herbs for two disorders. The leaky gut and phlegm syndromes look considerably similar with respect to related symptoms, diseases, and suitable herbal treatment agents, including phytochemicals even though limitations to compare exist. Phlegm may be spread throughout the body along with other pathogens via the disruption of the GI barrier to cause several diseases sharing some parts of symptoms, diseases, and mechanisms with leaky gut syndrome. Both syndromes are related to inflammation and gut microbiota compositions. Well-designed future research should be conducted to verify the interrelationships for evidence based integrative medicine to contribute to the promotion of public health. In addition, systems biology approaches should be adopted to explore the complex synergistic effects of herbal medicine and phytochemicals on conditions associated with phlegm and leaky gut syndromes.

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“…Stephania tetrandra (S. Moore) is a traditional Chinese medicine, belonging to the subgenus Botryodiscia of the genus Stephania in the Menispermaceae family ( Jiang et al, 2020 ; Zhang et al, 2020a ). It has been widely applied to therapy of rheumatoid arthritis, rheumatism, edema, and hypertension ( Jiang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been widely applied to therapy of rheumatoid arthritis, rheumatism, edema, and hypertension ( Jiang et al, 2020 ). Modern pharmacological studies have shown that it exhibits wide pharmacological activities, including anti-tumor, anti-inflammatory, neuroprotective, and antiviral effects ( Semwal et al, 2010 ; Jiang et al, 2020 ; Zhang et al, 2020a ). Previous chemical studies have documented that the active compounds of S. tetrandra include five types of benzylisoquinoline alkaloids (BIAs), including monobenzylisoquinolines, bisbenzylisoquinolines, aporphines, protoberberines, and tetrahydroprotoberberines ( Jiang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis of Stephania tetrandra and Characterization of Norcoclaurine-6-O-Methyltransferase Involved in Benzylisoquinoline Alkaloid Biosynthesis

Chen

Zhang

et al. 2022

Front. Plant Sci.

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Stephania tetrandra (S. Moore) is a source of traditional Chinese medicine that is widely used to treat rheumatism, rheumatoid arthritis, edema, and hypertension. Benzylisoquinoline alkaloids (BIAs) are the main bioactive compounds. However, the current understanding of the biosynthesis of BIAs in S. tetrandra is poor. Metabolite and transcriptomic analyses of the stem, leaf, xylem, and epidermis of S. tetrandra were performed to identify candidate genes associated with BIAs biosynthesis. According to the metabolite analysis, the majority of the BIAs accumulated in the root, especially in the epidermis. Transcriptome sequencing revealed a total of 113,338 unigenes that were generated by de novo assembly. Among them, 79,638 unigenes were successfully annotated, and 42 candidate structural genes associated with 15 steps of BIA biosynthesis identified. Additionally, a new (S)-norcoclaurine-6-O-methyltransferase (6OMT) gene was identified in S. tetrandra, named St6OMT2. Recombinant St6OMT2 catalyzed (S)-norcoclaurine methylation to form (S)-coclaurine in vitro. Maximum activity of St6OMT2 was determined at 30°C and pH 6.0 in NaAc-HAc buffer. Its half-life at 50°C was 22 min with the Km and kcat of 28.2 μM and 1.5 s−1, respectively. Our results provide crucial transcriptome information for S. tetrandra, shedding light on the understanding of BIAs biosynthesis and further gene functional characterization.

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History of uses, phytochemistry, pharmacological activities, quality control and toxicity of the root of Stephania tetrandra S. Moore: A review

Cited by 27 publications

References 37 publications

Intelligent Enhancement Algorithm-Based High Resolution CT Image in Evaluation of Expelling Wind and Relieving Cough and Asthma Prescription on Bronchial Asthma with High Immunoglobulin E Expression

Intelligent Enhancement Algorithm-Based High Resolution CT Image in Evaluation of Expelling Wind and Relieving Cough and Asthma Prescription on Bronchial Asthma with High Immunoglobulin E Expression

The Interrelationships between Intestinal Permeability and Phlegm Syndrome and Therapeutic Potential of Some Medicinal Herbs

Transcriptome Analysis of Stephania tetrandra and Characterization of Norcoclaurine-6-O-Methyltransferase Involved in Benzylisoquinoline Alkaloid Biosynthesis

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