Abstract:Treatment and long-term outcome in Slovenian children and adolescents, treated for acute lymphoblastic leukaemia (ALL) were evaluated, mainly considering diff erences between treatment regimens being evolved during time. From year 1967From year through 2004 were treated and six therapeutic schemes had been used. Retrospectively 5-year overall survival ± standard error (5yOS), relapse rate (RR) and second neoplasm (SN) were estimated according to treatment regimen, age, and where recorded, also according to… Show more
“…Papers coming from Poland [2], Czech Republic [3], Slovakia [4], Slovenia [5] and Serbia [6] will introduce the history of nationally unifi ed treatment of childhood ALL in each country before the ALLIC study has been launched. Despite all diffi culties, the paediatric oncologists have done their best to give chance of cure to children with ALL also in this part of Europe.…”
“…Papers coming from Poland [2], Czech Republic [3], Slovakia [4], Slovenia [5] and Serbia [6] will introduce the history of nationally unifi ed treatment of childhood ALL in each country before the ALLIC study has been launched. Despite all diffi culties, the paediatric oncologists have done their best to give chance of cure to children with ALL also in this part of Europe.…”
The ALL IC-BFM 2002 trial is a good example of international collaboration in pediatric oncology. A wide platform of countries able to run randomized studies in ALL has been established. Although the alternative DI did not improve outcome compared with standard treatment and the overall results are worse than those achieved by longer established leukemia groups, the national results have generally improved.
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