History of the Discovery and Development of Biomodulina T (InmunyVital®), a Useful Immunomodulator with a Broad Range of Clinical Applications

Martin, Roman R Rodriguez

doi:10.2139/ssrn.3678181

Cited by 2 publications

(12 citation statements)

References 24 publications

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“…Biomodulina T has been used in the treatment of infectious diseases, autoimmune diseases, immunodeficiency, and cancer (6,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). In 1994, we obtained approval for Biomodulina T as an immunomodulatory drug (27).…”

Section: Clinical Uses Of Biomodulina Tmentioning

confidence: 99%

“…Clinical trials have shown that Biomodulina T restores CD3+, CD4+, and CD8+ T-cells and their function and enhances the immune response against infections (6,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Biomodulina T restores immunosenescent CD4+ and CD8+ T-cells in older adults and improves the proliferative capacity of CD4+ T-cells and their ability to produce cytokines (26).…”

Section: Clinical Uses Of Biomodulina Tmentioning

confidence: 99%

“…Biomodulina T restores T-cells and immunity in immunocompromised people and in older adults and helps reverse immunosenescence. Clinical trials in immunodeficiency, autoimmune diseases, and infectious diseases show that Biomodulina T restores CD3+, CD4+, and CD8+ T-cells and their function and enhances the immune response against infections (6,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). In older adults, Biomodulina T increases the numbers of CD4+ naïve T-cells, CD4+ recent thymic emigrant (RTE) T-cells, CD8+ stem cell-like memory (SCM) T-cells, and CD4+ CD31+ naïve T-cells without changes in the frequency of regulatory T lymphocytes.…”

Section: T Cells Covid-19 and Biomodulina Tmentioning

confidence: 99%

“…In this laboratory, I discovered and led the development of a thymus factor that has an immunomodulatory effect. I named this thymic factor “Biomodulina T” (BMT) due to its main action as a biomodulator, and the letter T was chosen due to the origin of these factors, namely, the thymus gland, and the fundamental action of these factors in stimulating T lymphocytes ( 1 – 6 ).…”

Section: Discovery and Development Of Biomodulina Tmentioning

confidence: 99%

“…The newly formed active T rosettes are an early marker of T-cell activation. The increase in the percentage of active T rosettes is related to the ability of Biomodulina T to modulate T-cell functions ( 6 , 8 ).…”

Section: Biological Activity Of Biomodulina Tmentioning

confidence: 99%

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