History of Sunlight Exposure Is a Risk Factor for Age-Related Macular Degeneration

Schick, Tina; Ersoy, Lebriz; Lechanteur, Yara; Saksens, Nicole T.M.; Hoyng, Carel B.; Hollander, Anneke I. den; Kirchhof, Bernd; Fauser, Sascha

doi:10.1097/iae.0000000000000756

Cited by 84 publications

(78 citation statements)

References 23 publications

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“…The solar exposure, presumably due to ultraviolet rays, may interfere in AMD development. A similar prevalence of European inhabitants could be inferred for the Brazil's south region and (around 8 to 27%) and similar to central America in north region (4,9,(23)(24)(25)(26)(27) . A mean age of 73 years for AMD patients was found.…”

Section: Discussionsupporting

confidence: 49%

Epidemiological profile of age-related macular degeneration patients in Federal University of Parana, Brazil

Pradella¹,

Nisihara²,

Sato³

et al. 2016

Revista Brasileira De Oftalmologia

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Objective: To evaluate the profile and severity of age-related macular degeneration (AMD) in ophthalmology ambulatory of Federal University of Parana in Curitiba, Parana, Brazil. Methods: This was a cross-sectional study with data collected among the 6155 outpatients ophthalmic appointments (november 2011 to november 2013) Comparando com a literatura, uma maior proporção de casos avançados de DMRI (50% de forma exsudativa) foi encontrada. Em relação à etnia, tabagismo e IMC, não houve diferença entre pacientes com forma exsudativa e não exsudativa. Estes resultados podem ser comparados com estudos disponíveis, considerando a pouca informação referente a DMRI existente no Brasil.

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Section: Discussionsupporting

confidence: 49%

Epidemiological profile of age-related macular degeneration patients in Federal University of Parana, Brazil

Pradella¹,

Nisihara²,

Sato³

et al. 2016

Revista Brasileira De Oftalmologia

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“…Although epidemiological evidence of an association between sunlight exposure and AMD has been inconsistent over the years (48)(49)(50), recent studies have provided supported for such a link (51)(52)(53). The adverse consequences of lipofuscin bisretinoid photodegradation could be a pathway that explains this relationship.…”

Section: Discussionmentioning

confidence: 99%

Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

Ueda

Zhao

Kim

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

111

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Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisretinoid photodegradation is ongoing in the eye. High-performance liquid chromatography (HPLC) analysis of eyes of dark-reared and cyclic light-reared wild-type mice, together with comparisons of pigmented versus albino mice, revealed a relationship between intraocular light and reduced levels of the bisretinoids A2E and A2-glycero-phosphoethanolamine (A2-GPE). Analysis of the bisretinoids A2E, A2-GPE, A2-dihydropyridinephosphatidylethanolamine (A2-DHP-PE), and all-trans-retinal dimerphosphatidylethanolamine (all-trans-retinal dimer-PE) also decreases in albino Abca4 −/− mice reared in cyclic light compared with darkness. In albino Abca4 −/− mice receiving a diet supplemented with the antioxidant vitamin E, higher levels of RPE bisretinoid were evidenced by HPLC analysis and quantitation of fundus autofluorescence; this effect is consistent with photooxidative processes known to precede bisretinoid degradation. Amelioration of outer nuclear layer thinning indicated that vitamin E treatment protected photoreceptor cells. Conversely, in-cage exposure to short-wavelength light resulted in reduced fundus autofluorescence, decreased HPLC-quantified A2E, outer nuclear layer thinning, and increased methylglyoxal (MG)-adducted protein. MG was also released upon bisretinoid photodegradation in cells. We suggest that the lower levels of these diretinal adducts in cyclic lightreared and albino mice reflect photodegradative loss of bisretinoid. These mechanisms may underlie associations among AMD risk, oxidative mechanisms, and lifetime light exposure.bisretinoid | visual cycle | retina | retinal pigment epithelium | macular degeneration

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“…The pathogenesis of AMD, which is the main cause of blindness in the adult population of the developed countries, is complex and multifactorial, involving various genetic loci and environmental factors. There is considerable evidence in the literature that the OS is an important factor in the disease process . For instance, a recent study on a large cohort of participants evaluated the effects of current and past sunlight exposure, as well as the iris color on early and late AMD.…”

Section: Noncancer Ocular Pathologiesmentioning

confidence: 99%

“…There is considerable evidence in the literature that the OS is an important factor in the disease process . For instance, a recent study on a large cohort of participants evaluated the effects of current and past sunlight exposure, as well as the iris color on early and late AMD. They investigated the amount of self‐reported sun exposure the participants had in their past and more currently.…”

Section: Noncancer Ocular Pathologiesmentioning

confidence: 99%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

140

132

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In the eye, ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma and age-related macular degeneration. Possible OS signaling streams and mechanisms in the aging eye are discussed. Excessive exposure to UVR through live may seriously contribute to increase in OS of various eye tissues and thus lead to the advancement of serious ocular pathologies. Children are especially vulnerable to UVR because of their larger pupils and more transparent ocular media: up to 80% of a person's lifetime exposure to UVR is reached before the age of 18. Therefore, efficient everyday protection of the sensitive tissues of the eye by wearing of sunglasses, clear UVR-blocking spectacles or contact lenses should be considered from early age on. Many initiatives are taken worldwide to inform and raise the population's awareness about these possible UVR hazards to the eye.

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History of Sunlight Exposure Is a Risk Factor for Age-Related Macular Degeneration

Cited by 84 publications

References 23 publications

Epidemiological profile of age-related macular degeneration patients in Federal University of Parana, Brazil

Epidemiological profile of age-related macular degeneration patients in Federal University of Parana, Brazil

Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

Ultraviolet radiation oxidative stress affects eye health

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