History of Prostatitis Is an Independent Risk Factor for Erectile Dysfunction: A Cross-Sectional Study

Ma, Chengquan; Cai, Zhonglin; Xiong, Jian; Li, Hongjun

doi:10.1155/2020/8964673

Cited by 6 publications

(9 citation statements)

References 34 publications

(32 reference statements)

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“…Therefore, the prostate volume of patients with benign prostatic hyperplasia ED is very important, because the treatment of one disease may affect other disease, and vice versa. In addition, we also found that the history of prostatitis is also an independent risk factor for ED (11).…”

Section: Introductionsupporting

confidence: 65%

“…Word analysis can show the concepts where a particular study focuses on. In our study, keywords co-occurrence analysis showed that the highfrequency keywords were mainly erectile dysfunction, men, prostate cancer, quality-of-life, radical prostatectomy, sexual function, cancer, impotence, dysfunction and outcomes, etc., indicating that the research focused on the impact on ED due to various types of prostate diseases (9,11,(24)(25)(26). The majorities of these keywords were located in the middle of the network and were important as core words as they reflect the areas of interest in this field of research.…”

Section: Discussionmentioning

confidence: 99%

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Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study

Zhang

2021

Front. Oncol.

Self Cite

102

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ObjectivesTo identify the cooperation of authors, countries, institutions and explore the hot topics’ prospects regarding research of prostate diseases and erectile dysfunction (ED).MethodsPublications on research of prostate diseases and ED were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were performed using VOSviewer and CiteSpace software. Network maps were generated to evaluate the collaborations between different authors, countries, institutions, and keywords.ResultsA total of 2,599 articles related to study of prostate diseases and ED were identified. We observed gradually increasing in the number of publications from 1998 to 2016, and the trend was to be relatively stable in the past 3 years. Journal of Sexual Medicine (243 papers) owned the highest number of publications and Journal of Urology was the most co-cited journal. Mulhall John P (52 papers) was the top most productive authors and Mcvary Kebin T with the largest numbers of citations (1,589 co-citations) during the past decades. There were active collaborations among the top authors. The USA was the leading contributor in this field with 1,078 papers. Active cooperation between countries and between institutions was observed. The main hot topics included matters related to erectile dysfunction, prostate cancer, quality-of-life, radical prostatectomy, sexual function, and BPH.ConclusionBibliometric analysis provides a comprehensive overview of the development of scientific literature, allowing relevant authors and research teams to recognize the current research status in this field and at the same time provide a reference for formulating future research directions.

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Section: Introductionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study

Zhang

2021

Front. Oncol.

Self Cite

102

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“… 8 , 9 In many web survey studies, the IIEF-5 has been used as the crucial means of diagnosing ED. 46 , 47 However, several studies have found that the specificity of the IIEF-5 among the PE population is concerning. 34 , 35 , 36 …”

Section: Discussionmentioning

confidence: 99%

A Modified Procedure to Diagnose Erectile Dysfunction Using the International Index of Erectile Function (IIEF-6) Combined With the Premature Ejaculation Diagnosis Tool (PEDT) via an Internet Survey

et al. 2022

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Background The reliability of the International Index of Erectile Function (IIEF-5) in diagnosing erectile dysfunction (ED) is significantly decreased for the population with premature ejaculation (PE). Aim We aimed to illustrate a better way of diagnosing ED among the general population through a web survey study. Methods We collected online surveys from 2,746 men between the ages of 18 and 65. Two methods were used to determine the prevalence of ED, and these 2 methods were compared. Additionally, we divided our sample into 2 equally sized groups by median age and repeated the analyses for each group. In Method Ⅰ (M Ⅰ), men with an IIEF-5 score ≤ 21 were diagnosed with ED. In Method Ⅱ (M Ⅱ), PE was defined as a PEDT score ≥ 9, and no-PE was defined as a PEDT score ≤ 8. We used an IIEF-6 score cutoff of ≤ 24 among the PE population and a cutoff of ≤ 25 among the no-PE population to diagnose ED. Main outcome measures We examined the results from the IIEF-5, PEDT, and IIEF-6. Results Of the 2,746 men, 1,540 were in a stable heterosexual relationship, and the prevalence of ED among these men was determined. The prevalence of ED, as measured by Method Ⅰ, was significantly higher than that measured by Method Ⅱ. The kappa coefficients between the 2 methods were 0.595, 0.704, and 0.430 for the overall, no-PE, and PE populations, respectively. The internal consistency of the IIEF-5 for the PE population increased if Question 5 (intercourse satisfaction) was removed. Similar trends were observed for the groups, and there were no substantial differences. Clinical implications Our research suggests that before using the erectile function assessment scale to evaluate erectile function, ejaculatory function should be assessed with the PEDT. Strengths and limitations This was the first study to highlight the importance of evaluating ejaculatory function using the PEDT before diagnosing ED via an internet survey. There may have been recruitment bias because our study was an internet survey. Conclusion Establishing the prevalence of ED by using a combination of the IIEF-6 and PEDT was more reliable than using the IIEF-5 alone. Further validation of the modified procedure, especially regarding the effects of age on the results, in future studies is required.

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“…And men with ED had a possibility of previous CP/CPPS diagnosis three times more than control patients (Chung et al, 2012). Although epidemiological link between ED and CP/CPPS has been revealed, it isn't enough to explain their pathological relationship based on the current studies (Ma et al, 2020). Shoskes et al (2011) found that men with CP/CPPS tend to have evidence of greater endothelial dysfunction and arterial stiffness.…”

Section: Introductionmentioning

confidence: 89%

Uncovering the genetic links of diabetic erectile dysfunction and chronic prostatitis/chronic pelvic pain syndrome

Yuan

Sun²,

Han³

et al. 2023

Front. Physiol.

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Background: Clinical associations between erectile dysfunction and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been noticed, but the common pathogenic mechanisms between them remain elusive. The aim of the study was to mine shared genetic alterations between ED and chronic prostatitis/chronic pelvic pain syndrome.Method: Transcriptome data of ED and chronic prostatitis/chronic pelvic pain syndrome-related genes (CPRGs) were retrieved from relevant databases and differentially expressed analysis was used to obtain significant CPRGs. Then function enrichment and interaction analyses were performed to show shared transcriptional signature, including gene ontology and pathway enrichment, the construction of protein-protein interaction (PPI) network, cluster analysis, and co-expression analysis. Hub CPRGs and key cross-link were selected by validating these genes in clinical samples, chronic prostatitis/chronic pelvic pain syndrome and ED-related datasets. Then the miRNA-OSRGs co-regulatory network was predicted and validated. Subpopulation distribution and disease association of hub CPRGs were further identified.Result: Differentially expressed analysis revealed 363 significant CPRGs between ED and chronic prostatitis/chronic pelvic pain syndrome, functioning in inflammatory reaction, oxidative stress, apoptosis, smooth muscle cell proliferation, and extracellular matrix organization. A PPI network containing 245 nodes and 504 interactions was constructed. Module analysis depicted that multicellular organismal process and immune metabolic process were enriched. 17 genes were screened in PPI via topological algorithms, and reactive oxygen species as well as interleukin-1 metabolism were regarded as the bridging interactive mechanism. After screening and validation, a hub-CPRG signature consisting of COL1A1, MAPK6, LPL, NFE2L2 and NQO1 were identified and associated miRNA were verified. These miRNAs played an important role in immune and inflammatory response likewise. Finally, NQO1 was identified as a key genetic link between ED and chronic prostatitis/chronic pelvic pain syndrome. It was predominately enriched in corpus cavernosum endothelial cell, and correlated with other male urogenital and immune system diseases tightly.Conclusion: We identified the genetic profiles as well as corresponding regulatory network underlying interaction between ED and chronic prostatitis/chronic pelvic pain syndrome via multi-omics analysis. These findings expanded a new understanding for the molecular mechanism of ED with chronic prostatitis/chronic pelvic pain syndrome.

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History of Prostatitis Is an Independent Risk Factor for Erectile Dysfunction: A Cross-Sectional Study

Cited by 6 publications

References 34 publications

Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study

Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study

A Modified Procedure to Diagnose Erectile Dysfunction Using the International Index of Erectile Function (IIEF-6) Combined With the Premature Ejaculation Diagnosis Tool (PEDT) via an Internet Survey

Uncovering the genetic links of diabetic erectile dysfunction and chronic prostatitis/chronic pelvic pain syndrome

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