History of Otolaryngology: Globus Pharyngeus as “Globus Hystericus”

Lechien, J; Baudouin, Robin; Hans, Stéphane; Akst, Lee M.

doi:10.1177/01945998221093517

Cited by 6 publications

(4 citation statements)

References 13 publications

(52 reference statements)

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“…In unserem Kollektiv dominierte das weibliche Geschlecht (61,7 %) unter den Globuspatienten, was mit Daten anderer Studien übereinstimmt [13,14]. Hinsichtlich des durchschnittlichen Alters und des Gesamtscores des GETS-G wurde zwischen Frauen und Männern kein Unterschied festgestellt (p > 0,05).…”

Section: Originalarbeitunclassified

Reliabilität und Validität einer deutschen Version des Glasgow Edinburgh Throat Scale

Podzimek,

Jecker,

Koscielny

et al. 2024

Laryngorhinootologie

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Zusammenfassung Hintergrund Unter Globus, als Begriff für eine multifaktoriell bedingte Symptombeschreibung, leiden viele Patienten, die den HNO-Arzt aufsuchen. Dabei ist es gerade beim Erstkontakt wichtig, die oft sensibel veranlagten Patienten ernst zu nehmen und eine strukturierte diagnostische Abklärung anzubieten. Bislang fehlt im klinischen Alltag ein Screening-Instrument, mit dem man die Globussymptomatik näher differenzieren und ihren Schweregrad einschätzen kann. Fragestellung Es wurden die Reliabilität und Validität der deutschen Version der Glasgow Edinburg Throat Scale (GETS) untersucht. Material und Methoden Der Original-GETS-Fragebogen wurde in die deutsche Sprache (GETS-G) übersetzt und in einer prospektiven Beobachtungsstudie von 60 Patienten mit Globusgefühl (>3 Monaten) ausgefüllt. Alle Patienten wurden klinisch und sonografisch untersucht. Bei Patienten ohne feststellbare organische Ursache erfolgte zudem eine pH-Metrie. Ergebnisse Bei 30 Patienten (50%) konnte eine lokale organische Ursache für den Globus gefunden werden. Zudem wurde bei 24 Patienten (40%) ein Reflux mittels pH-Metrie nachgewiesen. Lediglich bei 6 Patienten (10%) konnte keine Ursache festgestellt werden. Im Hinblick auf den Gesamtscore (Q1–Q12) zeigte sich zwischen diesen 3 Gruppen kein signifikanter Unterschied. Der Cronbachs-Alpha zur Beurteilung der Reliabilität des GETS-G betrug bei der 12-Item-Analyse 0,88. Die Hauptkomponentenanalyse ergab eine Globusskala, eine Dysphagieskala und eine Skala für chronische Pharynxirritation. Schlussfolgerung Der GETS-G zeigte eine hohe Reliabilität und Validität, was den Einsatz bei Globuspatienten im deutschsprachigen Raum rechtfertig und zukünftig zu einer besseren Einschätzung des Schweregrads dieses Symptoms führen kann.

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Section: Originalarbeitunclassified

Reliabilität und Validität einer deutschen Version des Glasgow Edinburgh Throat Scale

Podzimek,

Jecker,

Koscielny

et al. 2024

Laryngorhinootologie

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“…[2][3][4] The lifetime incidence of transient or limited globus is believed to be as high as 50% in the adult population, typically occurring in the fourth or fifth decade and affecting 35% of males and 50% of females. 1,5 Persistent or recurrent globus pharyngeus (GP) has been reported to have a lifetime incidence of anywhere from 12.5% to 21.5% with a slight increased incidence in women, especially among patients under the age of 50. [6][7][8] It makes up approximately 4% of referrals to otolaryngologists and tends to be a chronic or recurring issue resulting in extensive workup due to lack of clear criteria, diagnostic algorithms, and concern for underlying malignancy.…”

Section: Introductionmentioning

confidence: 99%

“…For thousands of years, the condition of a globus sensation has been a common and challenging problem for physicians to treat 1 . Historically, it was attributed primarily to underlying psychiatric illness, dubbed “globus hystericus.” 2–4 The lifetime incidence of transient or limited globus is believed to be as high as 50% in the adult population, typically occurring in the fourth or fifth decade and affecting 35% of males and 50% of females 1,5 . Persistent or recurrent globus pharyngeus (GP) has been reported to have a lifetime incidence of anywhere from 12.5% to 21.5% with a slight increased incidence in women, especially among patients under the age of 50 6–8 .…”

Section: Introductionmentioning

confidence: 99%

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

Maronian,

Cabrera,

Dewey

et al. 2023

The Laryngoscope

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ObjectivesGlobus pharyngeus (GP) is a perplexing problem that accounts for 4% of referrals to otolaryngologists. Workup can be extensive and may not be definitive in terms of etiology. The concern that lingers is that of a subtle cancer, which can prolong anxiety and increase testing cost. The aim of this study was to identify the incidence of head and neck cancer (HNC) in patients diagnosed with GP.MethodsLongitudinal data were captured from two academic institutions, identifying patients with a new diagnosis of globus pharyngeus in 2015. The patient cohort was tracked for at least 4 years to assure follow‐up and ability to determine if a HNC developed. Additional demographic data was also collected to determine most common consults, treatments, and testing employed.ResultsExcluding patients with previous diagnosis of HNC, 377 patients were identified who presented with GP in 2015 that had at least 4 years of follow‐up. Demographics were predominantly women (64.65%), with a mean age of 56.48 years at diagnosis, and the most common provider specialty on the first visit was otolaryngology (39.52%). Four patients ultimately developed HN cancer, for an overall incidence of 1% for the 4‐year period of 2015–2019.ConclusionsGiven the long‐term follow‐up of this population, the overall incidence of developing a head and neck cancer, with a presenting symptom of globus, is low. This is the largest study to date to report the percentage of patients endorsing GP to then subsequently develop HNC. This helps otolaryngologists to reassure patients who have a normal comprehensive exam, flexible endoscopy, and targeted studies.Level of EvidenceIV Laryngoscope, 2023

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“…The development of artificial intelligence (AI)‐powered language models, such as Chatbot Generative Pretrained Transformer (ChatGPT), is emerging in medicine. ChatGPT has been used to respond to both simple and complicated questions related to medical examinations, and clinical vignettes, and may improve scientific reports through spelling correction or referencing 1‐3 . The accessibility and popularity of ChatGPT may encourage patients to use them for education prior to a medical consultation, 4 and young practitioners may consider ChatGPT‐4 as an adjunctive clinical tool for improving their practice.…”

mentioning

confidence: 99%

Performance and Consistency of ChatGPT‐4 Versus Otolaryngologists: A Clinical Case Series

Lechien,

Naunheim,

Maniaci

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveTo study the performance of Chatbot Generative Pretrained Transformer‐4 (ChatGPT‐4) in the management of cases in otolaryngology–head and neck surgery.Study DesignProspective case series.SettingMulticenter University Hospitals.MethodsHistory, clinical, physical, and additional examinations of adult outpatients consulting in otolaryngology departments of CHU Saint‐Pierre and Dour Medical Center were presented to ChatGPT‐4, which was interrogated for differential diagnoses, management, and treatment(s). According to specialty, the ChatGPT‐4 responses were assessed by 2 distinct, blinded board‐certified otolaryngologists with the Artificial Intelligence Performance Instrument.ResultsOne hundred cases were presented to ChatGPT‐4. ChaGPT‐4 indicated a mean of 3.34 (95% confidence interval [CI]: 3.09, 3.59) additional examinations per patient versus 2.10 (95% CI: 1.76, 2.34; P = .001) for the practitioners. There was strong consistency (k > 0.600) between otolaryngologists and ChatGPT‐4 for the indication of upper aerodigestive tract endoscopy, positron emission tomography and computed tomography, audiometry, tympanometry, and psychophysical evaluations. Primary diagnosis was correctly performed by ChatGPT‐4 in 38% to 86% of cases depending on subspecialty. Additional examinations indicated by ChatGPT‐4 were pertinent and necessary in 8% to 31% of cases, while the treatment regimen was pertinent in 12% to 44% of cases. The performance of ChatGPT‐4 was not influenced by the human‐reported level of difficulty of clinical cases.ConclusionChatGPT‐4 may be a promising adjunctive tool in otolaryngology, providing extensive documentation about additional examinations, primary and differential diagnoses, and treatments. The ChatGPT‐4 is more effective in providing a primary diagnosis, and less effective in the selection of additional examinations and treatments.

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History of Otolaryngology: Globus Pharyngeus as “Globus Hystericus”

Cited by 6 publications

References 13 publications

Reliabilität und Validität einer deutschen Version des Glasgow Edinburgh Throat Scale

Reliabilität und Validität einer deutschen Version des Glasgow Edinburgh Throat Scale

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

Performance and Consistency of ChatGPT‐4 Versus Otolaryngologists: A Clinical Case Series

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