History of Migraine Predicts Headache at High Altitude

Davis, Christopher; Reno, Elaine; Maa, Edward H.; Roach, Robert C.

doi:10.1089/ham.2016.0043

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…Alcohol consumption was one of the risk factors of AMS at Mount Kinabalu. Our finding contradicts previous studies that found alcohol consumption not to be a predictor of AMS (Schneider et al, 2002 ; Mairer et al, 2010 ; Davis et al, 2016 ). Some advised against the use of alcohol at a higher altitude as alcohol inhibits acute ventilation adaptation to mild hypoxia and impairs judgment (Roeggla et al, 1995 ; Klocke et al, 1998 ; Kim et al, 2016 ).…”

Section: Discussioncontrasting

confidence: 99%

Incidence and Determinants of Acute Mountain Sickness in Mount Kinabalu, Malaysia

Yang¹,

Ibrahim

Jenarun

et al. 2020

High Altitude Medicine & Biology

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Background: Acute mountain sickness (AMS) is the most common type of high-altitude sickness. The incidence of AMS varies by mountain location, trail characteristics, and study design. The lack of local epidemiology data has driven us to investigate the incidence and severity of AMS and its associated factors at Mount Kinabalu, Malaysia. Methods: A cohort study was conducted to collect data from climbers after days 1 (3272 m) and 2 (4095 m) of ascent. A self-administered questionnaire was used to explore climbers' demographic and climb characteristics, history of AMS, alcohol exposure, and AMS prevention measures. The Lake Louis score 2018 was used to assess the presence and severity of AMS (cutoff ‡3). Univariate and multivariable logistic regressions were performed to determine the factors associated with the development of AMS on day 2. Results: Data from 345 climbers were analyzed. The incidence of AMS was 23.9% (95% confidence interval [CI] 19.5%-28.7%) and 21.7% (95% CI 17.5%-26.3%) on days 1 and 2, respectively. The majority were mild cases. Experiencing AMS on day 1 (odds ratio [OR] = 12.88; 95% CI 6.71-24.75), alcohol consumption (OR = 3.73; 95% CI 1.66-8.39), receiving guide advice on day 1 (OR = 0.49; 95% CI 0.26-0.93), and age (OR = 0.96; 95% CI 0.93-0.99) were significant determinants of AMS at Mount Kinabalu. Gender, history of AMS, past exposure to high altitude, ascending time, water intake, acetazolamide use, physical fitness, pulse rate, and peripheral capillary oxygen saturation (SpO 2) were not associated with AMS at Mount Kinabalu. Conclusion: Future analysis with age strata is required to ascertain the association of age with AMS. Our research has signposted a strong call for collaborative efforts to improve the provision of hiking advice and discourage alcohol sales to mitigate the risk of AMS among Mount Kinabalu climbers.

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Section: Discussioncontrasting

confidence: 99%

Incidence and Determinants of Acute Mountain Sickness in Mount Kinabalu, Malaysia

Yang¹,

Ibrahim

Jenarun

et al. 2020

High Altitude Medicine & Biology

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“… 106 Some epidemiological data suggest an increased prevalence of migraine in HA populations 107 but also a worsening of both frequency and intensity of migraine episodes in low altitude residents during trekking or long flights. 108 There seems to be no difference between migraine without (M) or with aura (MA). M does not present an increased risk of developing cerebrovascular events, while in MA this risk is significantly increased even in young people with associated risk factors, such as smoking and oral contraceptive therapy.…”

Section: Literature and Research Methodsmentioning

confidence: 98%

Recommendations for traveling to altitude with neurological disorders

Falla

Giardini²,

Angelini

2021

J Cent Nerv Syst Dis

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Background Several neurological conditions might worsen with the exposure to high altitude (HA). The aim of this review was to summarize the available knowledge on the neurological HA illnesses and the risk for people with neurological disorders to attend HA locations. Methods A search of literature was conducted for several neurological disorders in PubMed and other databases since 1970. The neurological conditions searched were migraine, different cerebrovascular disease, intracranial space occupying mass, multiple sclerosis, peripheral neuropathies, neuromuscular disorders, epileptic seizures, delirium, dementia, and Parkinson’s disease (PD). Results Attempts were made to classify the risk posed by each condition and to provide recommendations regarding medical evaluation and advice for or against traveling to altitude. Individual cases should be advised after careful examination and risk evaluation performed either in an outpatient mountain medicine service or by a physician with knowledge of HA risks. Preliminary diagnostic methods and anticipation of neurological complications are needed. Conclusions Our recommendations suggest absolute contraindications to HA exposure for the following neurological conditions: (1) Unstable conditions–such as recent strokes, (2) Diabetic neuropathy, (3) Transient ischemic attack in the last month, (4) Brain tumors, and 5. Neuromuscular disorders with a decrease of forced vital capacity >60%. We consider the following relative contraindications where decision has to be made case by case: (1) Epilepsy based on recurrence of seizure and stabilization with the therapy, (2) PD (± obstructive sleep apnea syndrome-OSAS), (3) Mild Cognitive Impairment (± OSAS), and (4) Patent foramen ovale and migraine have to be considered risk factors for acute mountain sickness.

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“…14 Those patients would benefit taking daily triptans or non-steroidal anti-inflammatory drugs (NSAIDs) all through the menstrual period or during the duration of stay on high altitudes. 15 Control of other risk factors is also essential for migraine prevention e.g. weight loss and avoidance of psychological stress.…”

Section: Prevention Of Migrainementioning

confidence: 99%

Incidence, prevention and treatment of migraine

Alsaaid¹,

Alowaa²,

Abufaia³

et al. 2018

Int J Community Med Public Health

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Migraine is the second most common type of headache worldwide. It is estimated to affect about one sixth of population. Despite being a primary headache, it is severe, incapacitation, and disturbing normal daily life activity. Therefore, researchers and neuroscientists were and are still endeavouring to understand the basic mechanisms of migraine and its preventive strategies. Treatment of migraine is also a subject of continuous interest. Prevention of migraine is the cornerstone of migraine management. It is achieved by reducing exposure to risk factors, prophylactic treatment of recurrent migraines, and acute treatment prior to exposure to precipitating factors. Treatment of migraine refers to the acute management of headaches when they occur. Many medications are available for abortion or relief of headache, and the choice of which depends on many factors such as the patients' comorbidities, the headache characteristics and severity, the associated symptoms, the adverse events, and the patients' preferences. This article will review and discuss the incidence of migraine, its preventive measures, and treatment updates.

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History of Migraine Predicts Headache at High Altitude

Abstract: A history of migraine is a risk factor for the development of headache at altitude and is strongly associated with the development of migrainous headache.

Cited by 15 publications

References 18 publications

Incidence and Determinants of Acute Mountain Sickness in Mount Kinabalu, Malaysia

Incidence and Determinants of Acute Mountain Sickness in Mount Kinabalu, Malaysia

Recommendations for traveling to altitude with neurological disorders

Incidence, prevention and treatment of migraine

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