History of Meniere's disease and its clinical presentation

Mancini, Fernando; Catalani, Maurizio; Carru, Michela; Monti, Barbara

doi:10.1016/s0030-6665(02)00017-8

Cited by 54 publications

(52 citation statements)

References 66 publications

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“…In Meniere's disease, severe rotational, periodical and attack vertigos of 20 minutes to 2 to 3 hours in duration, tinnitus, nausea and vomiting, ear fullness [4], sweating and diarrhea have been seen in some patients. Furthermore, drop attack (Tumarkin attack) is seen in some patients with Meniere's disease, which are all included in questions of the questionnaire [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

DOV Questionnaire Manual for Therapists

Bina¹,

Forouhar²

2015

JOENTR

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Section: Discussionmentioning

confidence: 99%

DOV Questionnaire Manual for Therapists

Bina¹,

Forouhar²

2015

JOENTR

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“…However, an inflammatory pathogenesis of Meniere's disease has also been postulated. 30,31 The potential of ASF to serve as an anti-inflammatory agent should also be considered as a potential mechanism.…”

Section: Discussionmentioning

confidence: 99%

Distribution and immunoregulatory properties of antisecretory factor

Davidson

Hickey

2004

Laboratory Investigation

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Inflammatory processes and the mechanisms by which they are initiated and controlled within the central nervous system (CNS) involve a vast array of cell types and molecules. One cell type believed to be involved in the control of inflammation in the CNS is the microglial cell. The TLD antibodies are a panel of monoclonal antibodies reactive to rat microglial antigens. One antibody from this panel, clone TLD-1A8A, is specific for antisecretory factor (ASF). ASF is a previously identified protein characterized as a potent inhibitor of enterotoxin-induced intestinal fluid secretion. Our results extend the function of this molecule to include the regulation of immune reactions. Administration of TLD-1A8A to T-cell proliferation or mixed leukocyte response assays resulted in increased proliferation of T cells. Flow cytometric analysis indicates that ASF is expressed on macrophages, B cells and dendritic cells, but not on T cells or granulocytes. Immunohistochemical analysis indicates that ASF is expressed by macrophages and cells of dendritic morphology in the spleen, thymus, lymph nodes, Peyer's patch, and in the perivascular area in the CNS. Furthermore, Western blot analysis indicates that ASF is expressed in many tissues including all secondary lymphoid organs. These data suggest that ASF may have a previously unsuspected role in regulating the immune system.

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“…28 The diagnosis of MD is by exclusion, and a careful history is the most important guide to a correct diagnosis. 29 Criteria used to define MD are: the presence of at least two episodes of vertigo of at least 20 min duration, audiometrically confirmed sensorineural hearing loss on at least one occasion, tinnitus or aural fullness during episodes and exclusion of other possible causes of vertigo. 30 Its medical treatment is largely empiric and includes vestibular sedatives and anti-emetics, like diazepam and promethazine (during the acute attack).…”

Section: Ménière Diseasementioning

confidence: 99%

Management of vertigo: from evidence to clinical practice

Gnerre¹,

Casati

Frualdo³

et al. 2015

Ital J Med

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Vertigo is a symptom, not a diagnosis and effective diagnosis and management begin with understanding what this symptom may represent. Thus the presence of postural insility includes a differential diagnosis for otologic, neurologic and other medical causes. The objective of this paper is to provide evidence-based recommendations for the proper management of vertigo by multi-parametric analysis of the guidelines available to date.

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History of Meniere's disease and its clinical presentation

Cited by 54 publications

References 66 publications

DOV Questionnaire Manual for Therapists

DOV Questionnaire Manual for Therapists

Distribution and immunoregulatory properties of antisecretory factor

Management of vertigo: from evidence to clinical practice

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