History of Laser Ablation

Pacella, Claudio Maurizio; Mauri, Giovanni

doi:10.1007/978-3-030-21748-8_1

Cited by 7 publications

(10 citation statements)

References 28 publications

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“…Hence, wavelengths lying in these ranges can be employed in applications requiring higher light penetration within pancreatic tissue, whereas wavelengths in the 600–760 nm interval or close to the water peak at 980 nm are characterized by higher tissue attenuation (e.g., µ eff = 4.14 cm −1 @ 980 nm). The results are in line with the widespread use of specific wavelengths such as: (1) 1064 nm, i.e., one of the most utilized wavelengths for LA of focal malignancies 10 , 13 , (2) 800–808 nm, laser wavelengths often employed in studies concerning nanoparticle-mediated photothermal therapies and requiring high penetration depth 44 , (3) 975–980 nm wavelengths, utilized for laser-assisted thermotherapies 45 and typically associated with more elevated heating kinetics in biological media 46 – 48 due to higher absorption. Hence, the present work offers an experimental validation from the optical point of view of the utilization of these wavelengths on pancreatic tissue and may provide indications also on other usable wavelengths toward the most suitable wavelength selection according to the specific therapeutic application.…”

Section: Discussionsupporting

confidence: 81%

“…The rate of adverse events for LA is lower than with other thermal techniques 11 , 12 , and, among all thermal treatment modalities, LA is unique in enabling the use of a finer needle (i.e., diameter < 1 mm 10 ). Indeed, LA represents an attractive option for the treatment of focal lesions in high-risk locations, difficult-to-reach sites, or multiple nodules that differ in size.…”

Section: Introductionmentioning

confidence: 97%

“…Laser ablation (LA) technique, in particular, is a promising light-based ablative procedure that relies on a tissue temperature increase due to the photothermal conversion of laser radiation into heat. Malignant tissues, exposed to laser light, are therefore subjected to a localized and cytotoxic temperature rise while surrounding healthy structures are preserved from thermal damage 10 .…”

Section: Introductionmentioning

confidence: 99%

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Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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This work reports the optical properties of porcine pancreatic tissue in the broad wavelength range of 600–1100 nm. Absorption and reduced scattering coefficients (µa and µs′) of the ex vivo pancreas were obtained by means of Time-domain Diffuse Optical Spectroscopy. We have investigated different experimental conditions—including compression, repositioning, spatial sampling, temporal stability—the effect of the freezing procedure (fresh vs frozen-thawed pancreas), and finally inter-sample variability. Good repeatability under different experimental conditions was obtained (median coefficient of variation less than 8% and ~ 16% for µa and µs′, respectively). Freezing–thawing the samples caused an irreversible threefold reduction of µs′ and no effect on µa. The absorption and reduced scattering spectra averaged over different samples were in the range of 0.12–0.74 cm−1 and 12–21 cm−1 with an inter-sample variation of ~ 10% and ~ 40% for µa and µs′, respectively. The calculated effective transport coefficient (µeff) for fresh pancreatic tissue shows that regions between 800–900 nm and 1050–1100 nm are similar and offer the lowest tissue attenuation in the considered range (i.e., µeff ranging from 2.4 to 2.7 cm−1). These data, describing specific light-pancreas interactions in the therapeutic optical window for the first time, provide pivotal information for planning of light-based thermotherapies (e.g., laser ablation) and instruction of light transport models for biophotonic applications involving this organ.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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“…С изобретением американским физиком Теодором Майманом (Theodore Harold Maiman) в 1960 г. лазера на основе кристалла рубина началась эпоха применения этой технологии в различных сферах человеческой жизни, в том числе и медицине [23]. Уже в 1962 г. лазер нашёл своё первое практическое применение в медицине для микроспайки во время хирургии сетчатки.…”

Section: лазерная деструкция (аблация)unclassified

Methods of medical visualization and thermal ablation as a new approach to treatment of hyperparathyroidism

Олегович¹,

Румянцев²,

Bubnov

et al. 2021

Digital Diagnostics

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Introduction. The Pathologies of parathyroid glands are one of the most spread among endocrine system diseases excluding diabetes and thyroid pathology. Currently, there are only two methods which are used to treat hyperparathyroidism, such as: surgery and conservative therapy. However, in addition to them, methods of transracial thermal destruction (ablation) have recently appeared in clinical practice. The methods have a good precision and connect with physical phenomena such as: interaction laser, radiofrequency, microwave and HIFU irradiation with bio substance. Aim. The review is dedicated to a critical analysis of the modern methods for local thermal destruction of the parathyroid glands with hyperfunction. Materials and methods. The review includes data from randomized clinical trials from 2012 to 2021. The studies were found using Google Scholar, Pubmed. Total number of patients 1983 (laser ablation - 216 patients, radiofrequency ablation - 225, microwave ablation - 1467, high-density ultrasound ablation - 30 patients). Results. Recommendations for application of methods of thermal destruction was obtained during the review. Furthermore, We have designed some algorithm for treatment of hyperparathyroidism. Also methods of thermal destruction were observed. Conclusion. There are 4 modern methods of thermal destruction which have been analyzed like alternatives to surgery. Each of them has advantages and disadvantages, its own profile of safety and effectiveness. After processing information of proven database, the most popular among specialists is methods of microwave ablation. However, laser ablation is more effective than other ways.

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“…For minimally invasive treatment of AF with ablation, invasive imaging probes that are used for monitoring must have small lateral dimensions and a high degree of mechanical flexibility for integration into catheters. Previously, optical fibres have been used to deliver laser energy for ablation, providing high flexibility to reach high risk and deep-seated targets within the body 9 and high compatibility with different image guidance modalities during surgery 10 .…”

mentioning

confidence: 99%

Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging

Zhang

Beard

et al. 2022

Commun Eng

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All-optical ultrasound (OpUS) is an emerging high resolution imaging paradigm utilising optical fibres. This allows both therapeutic and imaging modalities to be integrated into devices with dimensions small enough for minimally invasive surgical applications. Here we report a dual-modality fibre optic probe that synchronously performs laser ablation and real-time all-optical ultrasound imaging for ablation monitoring. The device comprises three optical fibres: one each for transmission and reception of ultrasound, and one for the delivery of laser light for ablation. The total device diameter is < 1 mm. Ablation monitoring was carried out on porcine liver and heart tissue ex vivo with ablation depth tracked using all-optical M-mode ultrasound imaging and lesion boundary identification using a segmentation algorithm. Ablation depths up to 2.1 mm were visualised with a good correspondence between the ultrasound depth measurements and visual inspection of the lesions using stereomicroscopy. This work demonstrates the potential for OpUS probes to guide minimally invasive ablation procedures in real time.

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History of Laser Ablation

Cited by 7 publications

References 28 publications

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Methods of medical visualization and thermal ablation as a new approach to treatment of hyperparathyroidism

Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging

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