History of hadron therapy accelerators

Degiovanni, Alberto; Amaldi, U.

doi:10.1016/j.ejmp.2015.03.002

Cited by 42 publications

(24 citation statements)

References 36 publications

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“…Ionization-chamber type detectors are generally used for radiation dosimetry for patients [1]. Recently, high-energy proton and carbon beams have been used for radiotherapy because hadrons have a therapeutic effect for cancer than X-ray [2,3]. The biological effects depend on the linear energy transfer (LET) of the incident radiation.…”

Section: Introductionmentioning

confidence: 99%

Proton beam dosimetry using a TEPC with a 252Cf neutron calibration

Nam

Park

Lee

et al. 2015

Journal of the Korean Physical Society

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A tissue-equivalent proportional counter (TEPC) can measure the linear energy transfer (LET) of incident radiation and directly calculate the equivalent dose to humans in a complicated radiation field. For radiation monitoring, we developed and characterized a TEPC that can simulate a site diameter of 2 μm for micro-dosimetry. It was calibrated with a 252 Cf neutron standard source at the Korea Research Institute of Standards and Science. The channel to LET calibration factor of the TEPC is about 0.72 keV/μm-channel. Also, we evaluated the possibility of usage the TEPC as a proton dosimeter.

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Section: Introductionmentioning

confidence: 99%

Proton beam dosimetry using a TEPC with a 252Cf neutron calibration

Nam

Park

Lee

et al. 2015

Journal of the Korean Physical Society

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“…При этом практически вся доза поглощается тканями на последних миллиметрах пробега частиц -этот эффект носит название пика Брэгга. Теоретически преимущество протонного облучения заключается в возможности сфокусировать определенную дозу излучения на область поглощения в глубине здоровых тканей мозга практически без рассеивания и рас-ВОПРОСЫ НЕЙРОХИРУРГИИ 3,2017 пространения в тканях, лежащих на пути пучка протонов и за опухолью [53], т.е. облучение протонным пучком позволяет доставлять бóльшую дозу радиации в ткань опухоли без существенного увеличения рисков по сравнению с другими методами ЛТ.…”

Section: протонное облучениеunclassified

Radiotherapy and radiosurgery in treatment of craniopharyngiomas

2017

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Craniopharyngiomas are benign epithelial tumors having a dysembryogenetic origin, which are usually located in the sellar/parasellar and/or third ventricle regions. Gross total resection is the modern standard of treatment for these tumors because of a low recurrence rate. However, this surgery in some patients with craniopharyngioma often leads to the development or worsening of diencephalic disorders poorly responding to treatment. Perhaps, in these cases, subtotal or partial tumor resection or implantation of an Ommaya reservoir into the tumor cyst followed by stereotactic radiotherapy/radiosurgery may provide better functional outcomes and higher life quality in patients, with tumor growth control being reasonable (according to the published data, the mean 10-year disease-free survival is 66.9% after total tumor resection and 79.6% after combined treatment). The paper presents a review of the literature on radiological treatment of craniopharyngiomas. We discuss the issues of indications, optimal timing of radiotherapy/radiosurgery, its efficacy, and treatment outcomes in terms of complications and quality of life. Particular attention is paid to enlargement of craniopharyngioma cysts during and after radiological treatment.

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“…Gaining an understanding of how heavy charged particles lose energy as they travel through matter is fundamentally important for a wide range of fields including astrophysics [1], aviation and space exploration [2], and medical radiation therapy [3,4]. Developments at CERN with the ability of the antiproton decelerator (AD) to produce low-energy antiprotons have significantly increased interest in antiproton physics (see the review of Kirchner and Knudsen [5]).…”

Section: Introductionmentioning

confidence: 99%

Antiproton stopping power data for radiation therapy simulations

et al. 2016

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Stopping powers of H, He, H, and HO targets for antiprotons have been calculated using a convergent close-coupling method. For He and H targets electron-electron correlations are fully accounted for using a multiconfiguration approximation. Two-electron processes are included using an independent-event model. The water molecule is described using a neon-like structure model with a pseudo-spherical potential. Results are tabulated for the purpose of Monte Carlo simulations to model antiproton transport through matter for radiation therapy.

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History of hadron therapy accelerators

Cited by 42 publications

References 36 publications

Proton beam dosimetry using a TEPC with a 252Cf neutron calibration

Proton beam dosimetry using a TEPC with a 252Cf neutron calibration

Radiotherapy and radiosurgery in treatment of craniopharyngiomas

Antiproton stopping power data for radiation therapy simulations

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