History of cyclodextrin-based polymers in food and pharmacy: a review

Petitjean, Max; García-Zubiri, Iñigo X.; Isasi, José Ramón

doi:10.1007/s10311-021-01244-5

Cited by 44 publications

(30 citation statements)

References 143 publications

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“…These nanostructures have been widely used in the pharmaceutical, cosmetic, food, and environmental industries, targeting drug-delivery applications. To date, it has been demonstrated that they are very suitable within the food industry for the encapsulation of antimicrobial agents in packaging materials [ 24 , 76 , 130 ]. In this context, Simionato et al recently reported the encapsulation of cinnamon essential oil with α-CD and β-CD nanosponges, demonstrating their ability to encapsulate higher amounts of EOs [ 104 ].…”

Section: Methods Of Incorporating Cds In Polymer-based Active Food Packagingmentioning

confidence: 99%

“…As was mentioned above, this technology allows the protection and extension of the shelf life of a variety of foods but also offers a positive environmental impact due to its biodegradable nature [ 6 , 30 , 75 ]. When CDs are associated with biodegradable-polymer-based hosts, their potential applications increase and the packaging becomes entirely eco-friendly and biodegradable [ 76 , 77 ].…”

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

“…In recent years, several investigations have focused on the use of CICs to stabilize active substances, aiming to confer on the material its antioxidant, antimicrobial, and bioactive properties for food packaging applications. These complexes have also been applied to produce tailored packages as food preservatives [ 76 , 80 , 86 ]. In such materials, the release rate is of paramount importance and depends on: (i) the final concentration of the active substance within the polymer; (ii) the affinity for the cyclodextrin; (iii) the diffusion coefficient in the polymer; (iv) the partition coefficient between the polymer and the cyclodextrin, and between the polymer and the packaged product; and (iv) the temperature and time [ 28 , 34 ].…”

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

“…Concerning the current legislation, an interesting work has recently been published by Petitjean et al They reported on the legal aspect of using CDs in the food industry worldwide [ 76 ]. It is also worth noting that the Scientific Committee on Food (SCF), in a report published in 2016, concluded that, based on the available toxicological database, there is no reason to revise the current ADI of 5 mg/kg bw per day for β-cyclodextrin (E 459) [ 25 ].…”

Section: Toxicity and Legislation Of Cyclodextrins In Polymer-based Active Food Packagingmentioning

confidence: 99%

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Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

et al. 2021

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Using cyclodextrins (CDs) in packaging technologies helps volatile or bioactive molecules improve their solubility, to guarantee the homogeneous distribution of the complexed molecules, protecting them from volatilization, oxidation, and temperature fluctuations when they are associated with polymeric matrices. This technology is also suitable for the controlled release of active substances and allows the exploration of their association with biodegradable polymer targeting to reduce the negative environmental impacts of food packaging. Here, we present a fresh look at the current status of and future prospects regarding the different strategies used to associate cyclodextrins and their derivatives with polymeric matrices to fabricate sustainable and biodegradable active food packaging (AFP). Particular attention is paid to the materials and the fabrication technologies available to date. In addition, the use of cutting-edge strategies, including the trend of nanotechnologies in active food packaging, is emphasized. Furthermore, a critical view on the risks to human health and the associated updated legislation is provided. Some of the more representative patents and commercial products that currently use AFP are also listed. Finally, the current and future research challenges which must be addressed are discussed.

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Section: Methods Of Incorporating Cds In Polymer-based Active Food Packagingmentioning

confidence: 99%

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

Section: Incorporation Of Active Substances In Polymeric Matrix Composites For Active Packaging Applicationsmentioning

confidence: 99%

Section: Toxicity and Legislation Of Cyclodextrins In Polymer-based Active Food Packagingmentioning

confidence: 99%

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Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

et al. 2021

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“…Covalently linked cyclodextrin-containing macromolecular drug carrier systems have been investigated since the 1980s [ 1 ]. Several types of these macromolecular systems can be distinguished according to their structure such as linear polymers containing pendant cyclodextrin (CD) moieties [ 2 ], cross-linked cyclodextrin polymers [ 3 , 4 ] or polyrotaxanes [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Preformulation Studies and Bioavailability Enhancement of Curcumin with a ‘Two in One’ PEG-β-Cyclodextrin Polymer

et al. 2021

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Drug delivery systems are used to improve the biopharmaceutical properties of curcumin. Our aim was to investigate the effect of a water-soluble ‘two in one’ polymer containing covalently bonded PEG and βCD moieties (βCPCD) on the solubility and bioavailability of curcumin and compare it to a polymeric β-cyclodextrin (βCDP) cross-linked with epichlorohydrin. Phase-solubility and dynamic light scattering (DLS) experiments showed that the solubility of curcumin increased significantly in 10 m/m % βCPCD and βCDP solutions, but βCPCD–curcumin particles had higher hydrodynamic volume. The formation of the βCPCD–curcumin complex in solution and sedimented phase was confirmed by NMR spectroscopy. Biocompatibility and permeability experiments were performed on Caco-2 cells. Polymers did not show cytotoxicity up to 10 m/m % and βCPCD significantly increased the permeability of curcumin. DLS measurements revealed that among the interaction of polymers with mucin, βCPCD formed bigger aggregates compared to βCDP. Curcumin complexes were lyophilized into capsules and structurally characterized by micro-CT spectroscopy. Drug release was tested in a pH 1.2 medium. Lyophilized complexes had a solid porous matrix and both βCPCD and βCDP showed rapid drug release. βCPCD provides an opportunity to create a swellable, mucoadhesive matrix system for oral drug delivery.

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Cyclodextrin Polymers Functionalized with Histidine and Carcinine as Chelating Therapeutics for Copper Dyshomeostasis

Bognanni

Bellia²,

Vecchio

2023

ChemMedChem

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In recent years, cyclodextrin polymeric nanoparticles have been designed to introduce new properties and extend their medical applications. Based on the features of cyclodextrins, we derivatized cross‐linked cyclodextrin polymers with histidine or carcinine moieties. We found that amylases do not hydrolyze cyclodextrin polymers. The new polymers can form copper(II) complexes and may act as nanochelators to counteract copper(II) dyshomeostasis‐related diseases. Furthermore, the copper(II) complexes show superoxide dismutase activity, similar to free carcinine and histidine complexes. The antioxidant biological activity of the copper(II) complex formed in situ may protect cells from oxidative damage related to copper dyshomeostasis.

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History of cyclodextrin-based polymers in food and pharmacy: a review

Cited by 44 publications

References 143 publications

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

Preformulation Studies and Bioavailability Enhancement of Curcumin with a ‘Two in One’ PEG-β-Cyclodextrin Polymer

Cyclodextrin Polymers Functionalized with Histidine and Carcinine as Chelating Therapeutics for Copper Dyshomeostasis

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