History of benign breast disease and risk of breast cancer among women in China: a case–control study

Dorjgochoo, Tsogzolmaa; Deming, Sandra L.; Gao, Yu‐Tang; Lü, Wei; Ying, Zheng; Ruan, Zhi; Wang, Zheng; Shu, Xiao Ou

doi:10.1007/s10552-008-9145-6

Cited by 24 publications

(23 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports culled from western literature implicate premenopausal status, family history of breast cancer, delayed age at first live birth (>25 years) and low parity with increased risk of progression to invasive cancer in women biopsied for benign breast disease. [13][14][15] In 11 we found that majority (88.2%) of women with benign lumps are premenopausal, expressing yet greater concern for invasive cancer risk in young women in these populations. The discovery of seven (2.3%) premenopausal women with proliferative breast disease in this series further increases curiosity for higher cancer risk in young women with specific benign breast lumps.…”

Section: Discussionmentioning

confidence: 78%

“…8 The need for proper evaluation of breast lumps is further emphasized by the occurrence of a subset of benign breast lesions categorized as proliferative breast diseases. 8,[13][14][15] These variants confer increased risk of progression to malignancy and their histologic diagnosis mandates mammographic surveillance even after excision. 8,10,[13][14][15] Similarly, the relative risk of invasive breast cancer is higher in women with complex fibroadenomas and remained elevated for decades after diagnosis.…”

Section: South Eastern Nigeriamentioning

confidence: 99%

“…8,[13][14][15] These variants confer increased risk of progression to malignancy and their histologic diagnosis mandates mammographic surveillance even after excision. 8,10,[13][14][15] Similarly, the relative risk of invasive breast cancer is higher in women with complex fibroadenomas and remained elevated for decades after diagnosis. 14,15 This risk further increases in patients with concomitant family history of breast cancer.…”

Section: South Eastern Nigeriamentioning

confidence: 99%

“…8,10,[13][14][15] Similarly, the relative risk of invasive breast cancer is higher in women with complex fibroadenomas and remained elevated for decades after diagnosis. 14,15 This risk further increases in patients with concomitant family history of breast cancer. 14,15 Data on breast diseases are scanty in our setting despite the recent global clamor for increased awareness campaigns in different populations.…”

Section: South Eastern Nigeriamentioning

confidence: 99%

“…14,15 This risk further increases in patients with concomitant family history of breast cancer. 14,15 Data on breast diseases are scanty in our setting despite the recent global clamor for increased awareness campaigns in different populations. 1,8 Available data generated from similar surveys on breast diseases from other populations provided formidable opportunities for knowledge of the disease spectrum, counseling, intervention strategies, advocacy for breast health programs and screening for early detection of breast cancers.…”

Section: South Eastern Nigeriamentioning

confidence: 99%

See 4 more Smart Citations

Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria

et al. 2016

View full text Add to dashboard Cite

Aims and Objectives: Breast lumps are quite common, but the principal issue is differentiating malignant from the benign sub-groups. The determinants of histologic diagnosis are multifactorial, ranging from environmental, genetic to sex and age-related factors. This study aimed to document the spectrum of breast lumps in our environment. Materials and Methods: This is a descriptive prospective analysis of consecutive breast lumps biopsied at Federal Teaching Hospital Abakaliki, between December 2010 to November 2012. The data were analysed using statistical package for social sciences (SPSS) version 22.0. Results: A total of 302 patients with 359 breast lumps were seen, 298 females and 4 males giving male:Female ratio of 1:75.The ages of the patients ranged between 16-82 years with a mean of 37.0 +/-SD 13.0. Majority (56.3%) of the patients had benign lumps. Fibroadenoma was the commonest (33.8%), followed closely by invasive ductal carcinoma (32.8%), then fibrocystic change (17.2%).The occurrence of breast cancer was strongly age-related, being 1 in 5 biopsies at 20-29 years and 3 in 5 biopsies at 40-49 years age groups. Over two-third (69.0%) of 132 patients with breast cancers were premenopausal. Majority (78.8%) of the 132 patients with breast cancer presented with advanced disease. At a median follow up of 9 months,13 (9.8%) and 6(4.5%) of 132 cancer patients developed recurrences and new cancer sites respectively. Conclusion: Most patients with breast complaints present with lumps and majority are benign, fibroadenoma being the commonest histology. Occurrence of breast cancer is strongly age-related with majority of cancer patients presenting late.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: South Eastern Nigeriamentioning

confidence: 99%

Section: South Eastern Nigeriamentioning

confidence: 99%

Section: South Eastern Nigeriamentioning

confidence: 99%

Section: South Eastern Nigeriamentioning

confidence: 99%

See 3 more Smart Citations

Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria

et al. 2016

View full text Add to dashboard Cite

show abstract

Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era

Sherman,

Vierkant,

Winham

et al. 2024

JAMA Surg

View full text Add to dashboard Cite

ImportanceBenign breast disease (BBD) comprises approximately 75% of breast biopsy diagnoses. Surgical biopsy specimens diagnosed as nonproliferative (NP), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH) are associated with increasing breast cancer (BC) risk; however, knowledge is limited on risk associated with percutaneously diagnosed BBD.ObjectivesTo estimate BC risk associated with BBD in the percutaneous biopsy era irrespective of surgical biopsy.Design, Setting, and ParticipantsIn this retrospective cohort study, BBD biopsy specimens collected from January 1, 2002, to December 31, 2013, from patients with BBD at Mayo Clinic in Rochester, Minnesota, were reviewed by 2 pathologists masked to outcomes. Women were followed up from 6 months after biopsy until censoring, BC diagnosis, or December 31, 2021.ExposureBenign breast disease classification and multiplicity by pathology panel review.Main OutcomesThe main outcome was diagnosis of BC overall and stratified as ductal carcinoma in situ (DCIS) or invasive BC. Risk for presence vs absence of BBD lesions was assessed by Cox proportional hazards regression. Risk in patients with BBD compared with female breast cancer incidence rates from the Iowa Surveillance, Epidemiology, and End Results (SEER) program were estimated.ResultsAmong 4819 female participants, median age was 51 years (IQR, 43-62 years). Median follow-up was 10.9 years (IQR, 7.7-14.2 years) for control individuals without BC vs 6.6 years (IQR, 3.7-10.1 years) for patients with BC. Risk was higher in the cohort with BBD than in SEER data: BC overall (standard incidence ratio [SIR], 1.95; 95% CI, 1.76-2.17), invasive BC (SIR, 1.56; 95% CI, 1.37-1.78), and DCIS (SIR, 3.10; 95% CI, 2.54-3.77). The SIRs increased with increasing BBD severity (1.42 [95% CI, 1.19-1.71] for NP, 2.19 [95% CI, 1.88-2.54] for PDWA, and 3.91 [95% CI, 2.97-5.14] for AH), comparable to surgical cohorts with BBD. Risk also increased with increasing lesion multiplicity (SIR: 2.40 [95% CI, 2.06-2.79] for ≥3 foci of NP, 3.72 [95% CI, 2.31-5.99] for ≥3 foci of PDWA, and 5.29 [95% CI, 3.37-8.29] for ≥3 foci of AH). Ten-year BC cumulative incidence was 4.3% for NP, 6.6% for PDWA, and 14.6% for AH vs an expected population cumulative incidence of 2.9%.Conclusions and RelevanceIn this contemporary cohort study of women diagnosed with BBD in the percutaneous biopsy era, overall risk of BC was increased vs the general population (DCIS and invasive cancer combined), similar to that in historical BBD cohorts. Development and validation of pathologic classifications including both BBD severity and multiplicity may enable improved BC risk stratification.

show abstract

Associations of reproductive time events and intervals with breast cancer risk: A report from the Shanghai Breast Cancer Study

Huang

Beeghly–Fadiel

Gao

et al. 2013

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

While there is clear evidence for an association between later age at first live birth and increased breast cancer risk, associations of other reproductive timings are less clear. As breast tissues undergo major structural and cellular changes during pregnancy, we examined associations between reproductive time events and intervals with breast cancer risk among parous women from the population-based Shanghai Breast Cancer Study (SBCS). Unconditional logistic regression was used to evaluate associations with breast cancer risk for 3,269 cases and 3,341 controls. In addition to later age at first live birth, later ages at first pregnancy and last pregnancy were significantly associated with increased breast cancer risk (P-trend=0.002, 0.015, 0.008, respectively); longer intervals from menarche to first or last live birth were also associated with increased risks (P-trend<0.001, = 0.018, respectively). Analyses stratified by menopausal status and estrogen receptor (ER) / progesterone receptor (PR) status revealed that associations for later age at first pregnancy or live birth and longer intervals from menarche to first or last live birth occurred among pre-menopausal women and ER+/PR+ breast cancers, whereas the association for later age at last pregnancy occurred among postmenopausal women and ER+/PR- or ER-/PR+ breast cancers. Due to high correlation with other reproductive variables, models did not include adjustment for age at first live birth; when included, significance of all associations was attenuated. These findings suggest while reproductive time events and intervals play an important role in breast cancer etiology, contributions may differ by menopausal status and hormone receptor status of breast cancers.

show abstract

History of benign breast disease and risk of breast cancer among women in China: a case–control study

Abstract: Background: Data from the Shanghai Breast Cancer Study were analyzed to evaluate the relationship between benign breast disease (BBD) and breast cancer among Chinese women with a self-report of physician-diagnosed BBD.

Cited by 24 publications

References 49 publications

Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria

Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria

Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era

Associations of reproductive time events and intervals with breast cancer risk: A report from the Shanghai Breast Cancer Study

Contact Info

Product

Resources

About