History of androgens and androgen action

Handelsman, David J.

doi:10.1016/j.beem.2022.101629

Cited by 6 publications

(3 citation statements)

References 209 publications

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“…This study is pioneering in its thorough examination of smoking patterns among Chinese men suffering from primary and secondary infertility, whereby it categorized participants into smokers and nonsmokers and further distinguished smokers by intensity of consumption ( 18 ). Similar to the findings from Caster D et al.’s study, which reported significant reductions in sperm concentration among smokers compared to nonsmokers within a sample of 648 infertile males, our analysis extends these observations.…”

Section: Discussionmentioning

confidence: 99%

Associations between tobacco inhalation and semen parameters in men with primary and secondary infertility: a cross-sectional study

Fan,

Zhang,

Wang

et al. 2024

Front. Endocrinol.

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ObjectiveTo examine the impact of tobacco smoking on seminal parameters in men with both primary and secondary infertility.MethodsThis cross-sectional study analyzed 1938 infertile men from China who were categorized as nonsmokers (n=1,067) and smokers (n=871), with the latter group further divided into moderate smokers (1-10 cigarettes per day) (n=568) and heavy smokers (>10 cigarettes per day) (n=303). We assessed semen volume, concentration, total sperm count, progressive motility, and normal morphology following World Health Organization (WHO 2010) guidelines. A logistic regression model was used to analyze the relationships between smoking and seminal parameters while also controlling for lifestyle factors.ResultsThe analysis demonstrated a statistically significant correlation between smoking and adverse seminal parameters in both primary and secondary infertility patients. Specifically, primary infertile men who smoked had a lower semen concentration, with heavy smokers showing a median sperm concentration of 59.2×10^6/ml compared to 68.6×10^6/ml in nonsmokers (P=0.01). The secondary infertile men who smoked exhibited reduced forward sperm motility, with heavy smokers demonstrating a median progressive motility of 44.7%, which was significantly lower than the 48.1% observed in nonsmokers (P=0.04).ConclusionSmoking is significantly associated with detrimental effects on seminal parameters in infertile men, thus highlighting the need for cessation programs as part of fertility treatment protocols. Encouraging smoking cessation could substantially improve semen quality and fertility outcomes in this population.

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Section: Discussionmentioning

confidence: 99%

Associations between tobacco inhalation and semen parameters in men with primary and secondary infertility: a cross-sectional study

Fan,

Zhang,

Wang

et al. 2024

Front. Endocrinol.

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“…The primary cause for the large sex difference in athletic performance is exposure to high levels of endogenous testosterone in males at the onset of puberty (9,69). Testosterone is synthesized from cholesterol in the gonads and other tissues such as the adrenal glands, prostate, and liver (244). Testosterone mediates its effect by binding to the androgen receptor and the hormone-receptor complex serves as a transcription factor to modulate gene expression.…”

Section: Adulthoodmentioning

confidence: 99%

The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine

Hunter,

Angadi,

Bhargava

et al. 2023

Transl J ACSM

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Biological sex is a primary determinant of athletic performance because of fundamental sex differences in anatomy and physiology dictated by sex chromosomes and sex hormones. Adult men are typically stronger, more powerful, and faster than women of similar age and training status. Thus, for athletic events and sports relying on endurance, muscle strength, speed, and power, males typically outperform females by 10%–30% depending on the requirements of the event. These sex differences in performance emerge with the onset of puberty and coincide with the increase in endogenous sex steroid hormones, in particular testosterone in males, which increases 30-fold by adulthood, but remains low in females. The primary goal of this consensus statement is to provide the latest scientific knowledge and mechanisms for the sex differences in athletic performance. This review highlights the differences in anatomy and physiology between males and females that are primary determinants of the sex differences in athletic performance and in response to exercise training, and the role of sex steroid hormones (particularly testosterone and estradiol). We also identify historical and nonphysiological factors that influence the sex differences in performance. Finally, we identify gaps in the knowledge of sex differences in athletic performance and the underlying mechanisms, providing substantial opportunities for high-impact studies. A major step toward closing the knowledge gap is to include more and equitable numbers of women to that of men in mechanistic studies that determine any of the sex differences in response to an acute bout of exercise, exercise training, and athletic performance.

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“…Furthermore, insulin resistance and adipose tissue in the upper abdomen were associated with low testosterone. Type 2 diabetes (T2D) is associated with low testosterone (T) in large epidemiological studies [4,5]. A biological marker T was used in these studies and found to be frequently low in males with T2DM, often in conjunction with dyslipidaemia and abdominal fat.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Correlation of Hypogonadism in Men with Type 2 Diabetes

Ali¹,

Naeem²,

Naseer³

et al. 2022

PJMHS

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Aim: The present study aimed to determine the frequency and association of hypogonadism in men with type 2 diabetes mellitus. Material and Methods: This cross-sectional study was conducted on 242 type 2 DM male patients in the Department of General Medicine, Bahria International Hospital, Lahore from 16th January 2022 to 15th July 2022. The Androgen deficiency in aging male (ADAM) questionnaire was used for screening hypogonadal symptoms in the study group. The presence of low serum testosterone below 3 ng/mL and positive ADAM score was referred to as hypogonadism. T2DM patients with and without hypogonadism had their clinical and biochemical variables compared. Total testosterone, BMI, free testosterone, waist circumference, and sex hormone–binding globulin were measured. SPSS version 26 was used for data analysis. Results: Of the total 242 T2DM male patients, the prevalence of hypogonadism was 24.8% (n=60). The most prevalent symptoms in T2DM patients were hypogonadal symptoms. The overall mean age was 45.8± 9.63 years with range (25-70 years). Mean BMI value was 24.8 ± 3.64 kg/m2. The incidence of overweight and obese patients were 17.8% and 49.3% respectively. The prevalence of erectile dysfunction, reduced libido, and work performance deterioration in hypogonadism were 94.8%, 68.2%, and 56.3% respectively. T2DM patients without hypogonadism had lower a) incidence of diabetic neuropathy (18.6% vs. 43.8%; p=0.021), b) T2DM duration (5.3± 3.82 vs. 9.2± 4.9 years; P=0.002), c) occurrence of diabetic retinopathy (26.9% vs. 57.8%; P=0.006), and d) HbA1c (8.9± 1.53% vs. 9.9 ± 2.54%: P=0.005), and insulin therapy (21.5% vs. 45.8%: P=0.031) compared to those with hypogonadism. Conclusion: The present study found that prevalence of hypogonadism was 24.8% in type 2 diabetes mellitus. Patients with hypogonadism had higher HbA1c, higher prevalence of neuropathy and retinopathy, longer diabetic duration, and predominantly used insulin therapy than those T2DM patients without hypogonadism. Keywords: Hypogonadism, Type 2 diabetes mellitus, Androgen deficiency in aging male (ADAM).

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History of androgens and androgen action

Cited by 6 publications

References 209 publications

Associations between tobacco inhalation and semen parameters in men with primary and secondary infertility: a cross-sectional study

Associations between tobacco inhalation and semen parameters in men with primary and secondary infertility: a cross-sectional study

The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine

Frequency and Correlation of Hypogonadism in Men with Type 2 Diabetes

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