Histories of childhood maltreatment in schizophrenia: Relationships with premorbid functioning, symptomatology, and cognitive deficits

Schenkel, Lindsay S.; Spaulding, William D.; DiLillo, David; Silverstein, Steven M.

doi:10.1016/j.schres.2005.03.003

Cited by 197 publications

(194 citation statements)

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“…Patients with a first episode of psychosis and those with established schizophrenia who had experienced childhood trauma exhibited worse premorbid social and academic functioning compared with those without a history of childhood trauma (Schenkel et al 2005;Stain et al 2014). Childhood trauma has also been associated with functional deficits in adulthood in patients with schizophrenia (Lysaker et al 2001a;Spence et al 2006;Gil et al 2009;Choi et al 2011).…”

Section: Psychotic Disordersmentioning

confidence: 99%

“…These previous studies have largely examined functioning using structured questionnaire or scale measures, however, others have also examined the relationship between childhood trauma and 'real-world' outcomes. Childhood trauma has been associated with significantly lower age at first hospitalization and greater total number of hospitalizations among patients with schizophrenia (Schenkel et al 2005;Rosenberg et al 2007). Patients with a schizophrenia-spectrum diagnosis and a history of childhood sexual trauma also display impaired vocational functioning, working significantly fewer hours and exhibiting poorer occupational performance compared with those patients that had not experienced sexual trauma (Lysaker et al 2004(Lysaker et al , 2005.…”

Section: Psychotic Disordersmentioning

confidence: 99%

“…Childhood trauma has been associated with more severe depressive and anxiety symptoms (Lysaker et al 2005;Schenkel et al 2005;Spence et al 2006;Kingdon et al 2010;Addington et al 2013), among adults with psychosis and borderline personality disorder. Links between childhood maltreatment and the development of substance use problems in adulthood (Gilbert et al 2009;Schwandt et al 2013) also appear to extend to patients with schizophrenia and bipolar disorder (Rosenberg et al 2007;Lu et al 2008).…”

Section: Clinical Symptomsmentioning

confidence: 99%

“…Links between childhood maltreatment and the development of substance use problems in adulthood (Gilbert et al 2009;Schwandt et al 2013) also appear to extend to patients with schizophrenia and bipolar disorder (Rosenberg et al 2007;Lu et al 2008). Childhood trauma is also associated with more severe positive symptoms in people with psychotic disorders (Hammersley et al 2003;Lysaker et al 2005;Schenkel et al 2005;Berg et al 2014) and overall symptom severity in borderline personality disorder (Zanarini et al 2002). It may be that the presence of high levels of positive symptoms and significant anxiety, depressive and substance use comorbidity contributes to functional disability in patients with psychosis and borderline personality disorder.…”

Section: Clinical Symptomsmentioning

confidence: 99%

“…Likewise, the co-occurrence of PTSD and psychosis is again associated with more severe psychopathology and reduced treatment adherence (Schenkel et al 2005;Mueser et al 2010). However, childhood trauma may influence treatment outcome via mechanisms that go over and above the presence of PTSD.…”

Section: Implications For Clinical Managementmentioning

confidence: 99%

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Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

Cotter

Kaess

Yung

2014

Ir. j. psychol. Med.

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Objectives. We aimed to examine the association between childhood trauma and functional impairment in psychotic disorders, bipolar disorder and borderline personality disorder, to speculate on possible mechanisms that underlie this association and discuss the implications for clinical work.Methods. Narrative review of the peer-reviewed English language literature in the area.Results. High rates of childhood trauma in psychotic disorders, bipolar disorder and borderline personality disorder were identified. This was associated with impaired social and occupational functioning in both the premorbid and established phases of each of these psychiatric disorders over and above the deficits typically observed in these populations. Possible mechanisms mediating this relationship include neurocognitive deficits, insecure attachment, higher rates of comorbidities and problems with adherence and response to treatment. Conclusions.Routine clinical inquiry about childhood maltreatment should be adopted within mental health settings. This has potentially important treatment implications for identifying those individuals at elevated risk of functional disability. While there is no clear guidance currently available on how to target childhood trauma in the treatment of psychotic disorders, bipolar disorder or borderline personality disorder, there are several promising lines of enquiry and further research is warranted.

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