Histórico e importância da classificação de Bosniak para cistos renais complexos

Cobo, Rafael Moreira; Bittencourt, Leonardo Kayat

doi:10.1590/0100-3984.2014.47.6e3

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…All CT scans were performed by the same department and with the same device; moreover, the same expert physician evaluated the changes in cyst size and shape. The Bosniak grading classification was used to evaluate the cysts [ 13 14 ]. Sequential changes in the size of the renal cysts were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy

Grenader

Shavit

2015

Korean J Urol

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PurposeAlthough angiogenesis has been implicated in the promotion of renal cyst growth in autosomal dominant polycystic kidney disease, no studies have investigated the role of angiogenesis in the growth of simple renal cysts. The aim of current study was to investigate the effect of chemotherapy with the antivascular endothelial growth factor antibody bevacizumab on renal cyst development and growth in cancer patients.Materials and MethodsWe retrospectively reviewed the medical records of 136 patients with a variety of cancers that were treated with bevacizumab-based chemotherapy for metastatic disease. The presence of and changes in renal cysts were evaluated by retrospective analysis of computed tomography scans performed for assessment of tumor response to bevacizumab-based therapy.ResultsThe median age of the patients was 64 years. Renal cysts were identified in 66 patients, in whom 33 (50%) had a single cyst and the rest had 2 or more cysts. The average dose of bevacizumab was 2.68 mg/kg per week. Median duration of treatment was 33 weeks. Average cyst size was 1.9±2.4 cm at the beginning of the study and the majority of the cysts (54 patients, 84%) did not change in size or shape during bevacizumab treatment. No patients were identified with new cysts. Cyst size changed in 10 patients (16%): an increase of 15% to 40% from the baseline size in 5 patients and a decrease in size of 10% to 70% in another 5 patients. The duration of bevacizumab therapy was significantly longer in the subgroup of patients with diminished or increased cyst size than in the patients with stable cyst size: 62 weeks versus 29 weeks, respectively (p=0.0002).ConclusionsOur data demonstrated that simple renal cysts were stable in size and number in the vast majority of cancer patients treated with bevacizumab.

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Section: Methodsmentioning

confidence: 99%

Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy

Grenader

Shavit

2015

Korean J Urol

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“…Bosniak classification is commonly used both by radiologists and urologists today. A score between I and IV is given to the lesions in the classification; while score I defines a simple cyst,score IV describes cysts with solid component and high malignity potential (1) . While Bosniak I and II lesions are regarded as benign and require no surveillance, excision is recommended for Bosniak III and Bosniak IV lesions as 40-60% of Bosniak III lesions and more than 80% of Bosniak IV lesions have malignancy risk.…”

Section: Introductionmentioning

confidence: 99%

Approach to Complex Renal Cysts: A Single Center Experience

Güner¹,

Kalfazade²

2021

BMJ

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Objective: Our objective in this study was to present the data for patients followed-up and underwent surgery due to complex renal cyst using Bosniak classification system. Method: Data of all patients followed-up or underwent surgery via open / minimal invasive methods due to complex renal cyst in our clinic between 2016 and 2019 were retrospectively evaluated. Bosniak category IIF and higher lesions were included in the study. Results: A total of 83 patients were included in the study. The mean age of the patients was 52 ±10.1 years and 40 (48.2%) were male and 43 (51.8%) were female. 53 (63.9%) patients had Bosniak IIF, 18 (21.7%) patients had Bosniak III and 12 (14.5%) patients had Bosniak IV lesions. Mean lesion size was 54±27.4 mm. Surgery was performed in a total of 41 (49.4%) patients. Based on final pathology result, while benign pathologies were detected in 13 (31.7%) patients, clear cell renal cell carcinoma was detected in 22 (53.7%) patients and papillary renal cell carcinoma in 6 (14.6%) patients. Malignity rates were detected as 18.9%, 44.4% and 83.3% in Bosniak IIF, III and IV lesions respectively. While the mean lesion size of patients who had benign pathology were 64.6±18.4 mm, mean lesion size of patients with malign pathology were 58.3±29.7 mm (p =.41). Conclusion: Progression is an important malignity finding in Bosniak IIF lesions. An important amount of especially Bosniak III lesions is overtreated. Thus, active surveillance is a treatment which should be considered in these patients. More comprehensive prospective randomized studies are needed.

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Histórico e importância da classificação de Bosniak para cistos renais complexos

Cited by 2 publications

References 18 publications

Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy

Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy

Approach to Complex Renal Cysts: A Single Center Experience

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