Historical Use of Toxic Plants

Anywar, Godwin

doi:10.1002/9781119650034.ch1

Cited by 7 publications

(7 citation statements)

References 59 publications

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“…A plant species is defined as poisonous if it can harm humans or animals with a sufficient quantity upon touching or ingesting (Serrano, 2018). For thousands of years, poisonous plants have been used for different purposes such as hunting, fishing or fighting, and also for treating diseases (Anywar, 2020). Besides the poisoning effects, they can act as medicinal herbs if used in small amounts or in correct proportions (Serrano, 2018).…”

Section: Introductionmentioning

confidence: 99%

Indigenous knowledge of poisonous plants from Van Kieu and Pa Ko ethnic groups in Quang Tri province, Vietnam

Chi¹,

Linh²,

Giang³

et al. 2023

AJB

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Poisonous plants are known for toxicity to humans and animals. They comprise a large group of plants in the world. This study aims to collect and systematically document the traditional knowledge of poisonous plants by interviewing Van Kieu and Pa Ko ethnic communities in Quang Tri province. A total of 56 poisonous plant species (27 herbs, 15 shrubs and 14 woody plants) of flowering plants belonging to 26 families and 50 genera were found in the study site. Based on the Recorded Poisonous Plant Proportion (RPPP) values, 25 commonly recorded poisonous plants were selected for analyzing Fidelity Level (FL) and Informants Consensus Factor (ICF). The ICF value of eye irritation, neurologic category, skin irritation, gastrointestinal category and respiratory/cardiovascular category was 0.97, 0.97, 0.96, 0.93 and 0.92, respectively. The most notable species (FL: 100%) in the gastrointestinal category were Ricinus communis L. and Millettia erythrocalyx Gagnep. In the respiratory/cardiovascular category, the most important species (FL: 100%) were Gelsemium elegans (Gardner & Champ.) Benth. and Strychnos vanprukii Craib. The presented results will provide fundamental information for further phytochemical and biological investigation to ascertain the toxic compounds of poisonous plants that may be used for the treatment of appropriate diseases.

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Section: Introductionmentioning

confidence: 99%

Indigenous knowledge of poisonous plants from Van Kieu and Pa Ko ethnic groups in Quang Tri province, Vietnam

Chi¹,

Linh²,

Giang³

et al. 2023

AJB

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“…Toxic plants are often avoided except for well-informed applications such as for fishing, hunting etc. [ 5 ]. While the ubiquitously distributed primary plant metabolites including proteins, lipids and carbohydrates mainly serve nutritional purposes, the species-specific secondary compounds have been shown to produce pharmacologic or toxic activities [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional and Pharmaceutical Applications of Under-Explored Knottin Peptide-Rich Phytomedicines

Attah

Lawal

Yusuf

et al. 2022

Plants

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Phytomedicines reportedly rich in cystine knot peptides (Knottins) are found in several global diets, food/herbal supplements and functional foods. However, their knottin peptide content has largely been unexplored, notably for their emerging dual potentials at both the food and medicine space. The nutritional roles, biological targets and mechanism(s) of activity of these knotted peptides are largely unknown. Meanwhile, knottins have recently been unveiled as emerging peptide therapeutics and nutraceuticals of primary choice due to their broad spectrum of bioactivity, hyper stability, selective toxicity, impressive selectivity for biomolecular targets, and their bioengineering applications. In addition to their potential dietary benefits, some knottins have displayed desirable limited toxicity to human erythrocytes. In an effort to appraise what has been accomplished, unveil knowledge gaps and explore the future prospects of knottins, an elaborate review of the nutritional and pharmaceutical application of phytomedicines rich in knottins was carried out. Herein, we provide comprehensive data on common dietary and therapeutic knottins, the majority of which are poorly investigated in many food-grade phytomedicines used in different cultures and localities. Findings from this review should stimulate scientific interest to unveil novel dietary knottins and knottin-rich nutraceutical peptide drug candidates/leads with potential for future clinical application.

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“…[ 5 ]. However, these plants are widely used for specific purposes by people to treat certain critical disorders [ 6 , 7 , 8 ]. Since ancient times, the necessity to explore plants’ activity against various diseases has remained continued, and the approaches to the scientific confirmations of phytochemicals’ biological activity are a well-established tactic for new drug discovery, and drug development in modern times [ 6 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

Mohammed

Ali

Qureshi

et al. 2021

Plants

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Four halophytic plants, Lycium shawii, Anabasis articulata, Rumex vesicarius, and Zilla spinosa, growing in the central Qassim area, Saudi Arabia, were phytochemically and biologically investigated. Their hydroalcoholic extracts’ UPLC-ESIQ-TOF analyses demonstrated the presence of 44 compounds of phenolic acids, flavonoids, saponins, carbohydrates, and fatty acids chemical classes. Among all the plants’ extracts, L. shawii showed the highest quantities of total phenolics, and flavonoids contents (52.72 and 13.01 mg/gm of the gallic acid and quercetin equivalents, respectively), along with the antioxidant activity in the TAA (total antioxidant activity), FRAP (ferric reducing antioxidant power), and DPPH-SA (2,2-diphenyl-1-picryl-hydrazyl-scavenging activity) assays with 25.6, 56.68, and 19.76 mg/gm, respectively, as Trolox equivalents. The hydroalcoholic extract of the L. shawii also demonstrated the best chelating activity at 21.84 mg/gm EDTA equivalents. Among all the four halophytes, the hydroalcoholic extract of L. shawii exhibited the highest antiproliferative activity against MCF7 and K562 cell lines with IC50 values at 194.5 µg/mL and 464.9 µg/mL, respectively. The hydroalcoholic extract of A. articulata demonstrated better cytotoxic activity amongst all the tested plants’ extracts against the human pancreatic cancer cell lines (PANC1) with an IC50 value of 998.5 µg/mL. The L. shawii induced apoptosis in the MCF7 cell lines, and the percentage of the necrotic cells changed to 28.1% and 36.5% for the IC50 and double-IC50 values at 22.9% compared with the untreated groups. The hydroalcoholic extract of L. shawii showed substantial antibacterial activity against Bacillus cereus ATCC 10876 with a MIC value of 12.5 mg/mL. By contrast, the A. articulata and Z. spinosa exhibited antifungal activities against Aspergillus niger ATCC 6275 with MIC values at 12.5 and 50 mg/mL, respectively. These findings suggested that the L. shawii is a potential halophyte with remarkable biological properties, attributed to its contents of phenolics and flavonoid classes of compounds in its extract.

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Historical Use of Toxic Plants

Cited by 7 publications

References 59 publications

Indigenous knowledge of poisonous plants from Van Kieu and Pa Ko ethnic groups in Quang Tri province, Vietnam

Indigenous knowledge of poisonous plants from Van Kieu and Pa Ko ethnic groups in Quang Tri province, Vietnam

Nutritional and Pharmaceutical Applications of Under-Explored Knottin Peptide-Rich Phytomedicines

Comparative Phytochemical Profile and Biological Activity of Four Major Medicinal Halophytes from Qassim Flora

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