Minnesota is home to two of the pioneering institutions that ushered in the golden era of modern cardiac surgery. Clinicians and researchers at the Mayo Clinic and the University of Minnesota built on this momentum and began translating clinical research directly to the bedside. This legacy continues today. Minnesota has a rich history and track record of translating clinical research to the bedside and developing medical device companies that have benefited investigators, patients, and the economy. We will give a brief overview of this model and the steps to success which can be duplicated by other states and countries.