Historical Perspective and Future Direction of Blood Vessel Developments

Dimitrievska, Sashka; Niklason, Laura E.

doi:10.1101/cshperspect.a025742

Cited by 53 publications

(50 citation statements)

References 60 publications

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“…The major advantage of the biodegradable vascular grafts over biostable ones is better endothelialization, a process pivotal for the prevention of thrombotic occlusion [9][10][11]. However, thrombosis generally occurs within the first minutes or hours upon contact of the blood with the polymer surface, negating improved biocompatibility of biodegradable polymers.…”

mentioning

confidence: 99%

Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature

Kutikhin

Tupikin

Матвеева

et al. 2020

Cells

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Endothelial colony-forming cells (ECFC) are currently considered as a promising cell population for the pre-endothelialization or pre-vascularization of tissue-engineered constructs, including small-diameter biodegradable vascular grafts. However, the extent of heterogeneity between ECFC and mature vascular endothelial cells (EC) is unclear. Here, we performed a transcriptome-wide study to compare gene expression profiles of ECFC, human coronary artery endothelial cells (HCAEC), and human umbilical vein endothelial cells (HUVEC). Characterization of the abovementioned cell populations was carried out by immunophenotyping, tube formation assay, and evaluation of proliferation capability while global gene expression profiling was conducted by means of RNA-seq. ECFC were similar to HUVEC in terms of immunophenotype (CD31 + vWF + KDR + CD146 + CD34 -CD133 -CD45 -CD90 -) and tube formation activity yet had expectedly higher proliferative potential. HCAEC and HUVEC were generally similar to ECFC with regards to their global gene expression profile; nevertheless, ECFC overexpressed specific markers of all endothelial lineages (NRP2, NOTCH4, LYVE1), in particular lymphatic EC (LYVE1), and had upregulated extracellular matrix and basement membrane genes (COL1A1, COL1A2, COL4A1, COL4A2). Proteomic profiling for endothelial lineage markers and angiogenic molecules generally confirmed RNA-seq results, indicating ECFC as an intermediate population between HCAEC and HUVEC. Therefore, gene expression profile and behavior of ECFC suggest their potential to be applied for a pre-endothelialization of bioartificial vascular grafts, whereas in terms of endothelial hierarchy they differ from HCAEC and HUVEC, having a transitional phenotype.

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mentioning

confidence: 99%

Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature

Kutikhin

Tupikin

Матвеева

et al. 2020

Cells

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“…The main criteria for engineering a long-lasting artery include high compliance/tensile mechanical properties, low thrombogenicity, and regenerative remodeling that ultimately leads to successful integration (Dimitrievska and Niklason, 2017). After immediately branching off the aorta, arteries must be compliant enough to accommodate flow with highly pulsatile pressure and tensile enough to prevent rupture.…”

Section: Engineering Of Arterial Vesselsmentioning

confidence: 99%

“…In comparison, iPSC derived SMCs have been shown to generate abundant collagen within 8–9 weeks of culture time (Gui et al, 2016). The enhanced proliferative capacity demonstrated by both adult stem cells and iPSCs thus may not only reduce production time but also eliminate the need for harvesting cells from patients or donors (Dimitrievska and Niklason, 2017). Vascular engineering is not only important for generating large vessels, but also for generating microvasculature, for example, to support the engineering of organs and tissues ex vivo .…”

Section: Future Directionsmentioning

confidence: 99%

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

et al. 2018

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Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. We also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology.

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“…Blood vessels are components of the circulatory systems with hollow tube structures in the tissue and organs [131]. These transport blood cells, oxygen, and nutrients throughout the body and receive the CO 2 and waste from the metabolic activity of the peripheral cells and tissues.…”

Section: Blood Vesselmentioning

confidence: 99%

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

et al. 2020

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It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.

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Historical Perspective and Future Direction of Blood Vessel Developments

Cited by 53 publications

References 60 publications

Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature

Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

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