Historical Perspective*

Abstract

Opium, cannabis and cocaine have a long and colourful history which can be seen in perspective at the beginning of this century. The questions asked then were very like those we are asking now.

Agnogenic myeloid metaplasia (AMM)—correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients

“…Our longitudinal study on clinical and histomorphological features in 114 patients with AMM confirmed the remarkable variability of hematological as well as histological findings in this disorder and further demonstrated that these certainly reflect different stages in the extent of disease (Lewis, 1985;Georgii et al, 1984a,b;Burkhardt er al., 1984Burkhardt er al., , 1986Geary, 1985). Consequently all these features were thought to represent static parameters obtained at variable periods in the progress of AMM.…”

“…Histological studies of the bone marrow suggested that AMM may include (pan-)hyperplastic as well as osteosclerotic changes (Pitcock et al, 1962;Silverstein, 1975;Buyssens and Bourgeois, 1977;Georgii et al, 1984a,b;Lewis, 1985). These were thought to reflect also different phases in the progress ofdisease (Burkhardt et al, ,1986Georgii et al, 1984a,b;Frisch et al, 1984;Lewis, 1985;Frisch and Bartl, 1985).…”

“…These were thought to reflect also different phases in the progress ofdisease (Burkhardt et al, ,1986Georgii et al, 1984a,b;Frisch et al, 1984;Lewis, 1985;Frisch and Bartl, 1985). Previous studies were mainly focussed on histological findings of sequential bone marrow biopsies taken at different intervals, however with missing or no clear reference to corresponding hematological data and/or subtype of CMPD, i.e.…”

“…From previous studies it is obvious that patients with AMM present with strikingly variable clinical (Bouroncle and Doan, 1962;Ward and Block, 1971;Varki et al, 1983;Lewis, 1985;Geary, 1985) as well as histomorphological features (Linman and Bethell, 1957;Pitcock et a/., 1962;Rosenthal and Moloney, 1969;Silverstein, 1975;Lohmann and Beckman, 1983;Frisch et al, 1984;Georgii et al, 1980Georgii et al, , 1984aFrisch and Bartl, 1985;Burkhardt et al, 1984Burkhardt et al, , 1986 at diagnosis. Initially a leukoerythroblastic blood reaction with tear-drop poikilocytosis may be inconspicuous in many patients.…”

“…Similar to the complexity of initial clinical parameters, there is also a remarkable variety of histomorphological features observable in the bone marrow on first examination of such patients with AMM. Generally an 'early' (pan-) hyperplastic or hypercellular phase presenting with minimal or moderate reticulin fibrosis is distinguishable from a 'late' fibro-osteosclerotic lesion showing coarse bundles of collagen and a facultative formation of appositional woven boneosteosclerosis (Silverstein, 1975;Burkhardt et al, 1984Burkhardt et al, , 1986Georgii et al, 1984a,b;Frisch and Bartl, 1985;Lewis, 1985). Considering those remarkable differences in clinical as well as histomorphological findings in AMM the present study is focussed on the following problems: ( I ) Possible relationships between those different morphological and hematological features on admission which may explain the variable laboratory data at diagnosis.…”