Historical outbreak of Salmonella hadar

Deshpande, Abhishek; Curran, Evonne T; Jamdar, Sami Faisal; Inkster, Teresa; Jones, Brian

doi:10.1016/j.jhin.2015.05.014

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The reason for this increased incidence may be that some isolates were misidentified as other serotypes due to use of commercial antisera or other factors from 2006 to 2012. 29 The less common serotypes, such as S. Goldcoast 30 and S. Hadar, 31 have gradually increased in incidence in recent years. The most frequently isolated Salmonella serotypes in European countries, such as S. Java, S. Jangwani, S. Manhattan, and S. Pomona are associated with exotic pets, 32 which could be due to international travel, human migration, and food, animal feed, and livestock trade.…”

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confidence: 99%

Epidemiology, Serotype and Resistance of Salmonella Isolates from a Children’s Hospital in Hangzhou, Zhejiang, China, 2006–2021

Yue¹,

Liu²,

Li³

et al. 2022

IDR

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This research investigated the dynamics of antibiotic resistance in Salmonella and the epidemiology of Salmonella infection in children. These data can aid in the prevention and control of the Salmonella epidemic and the diagnosis and treatment of salmonellosis. Methods: In this study, we retrospectively reviewed and analysed data regarding epidemiology, clinical symptoms, Salmonella serotypes, and antibiotic resistance from the medical records of patients with Salmonella infections in Hangzhou Children's Hospital from April 2006 to December 2021. Results: A total of 2099 Salmonella isolates were identified during the 16-year study period, and 98.6% (2069) of the isolates were isolated from stool. About 84.5% (1773/2099) of the total Salmonella isolates were detected from May to October. The median age of the 2099 children with Salmonella infection was 1.4 years (17 months) (IQR: 0.9-2.8 years). In 1572 (74.9%) patients, the course of the disease was limited to uncomplicated gastroenteritis. S. Typhimurium (805/2099, 38.4%) was predominant, followed by S. Enteritidis (290/2099, 13.8%). The total number of serotypes and the number of less common serotypes are increasing. Nontyphoid Salmonella that cause invasive infections, including S. Typhimurium, S. Stanley, and S. Choleraesuis, accounted for 60.0% (18/30). The Salmonella strains were resistant to ampicillin, ampicillin-sulbactam, trimethoprim-sulfamethoxazole, ceftriaxone, and ciprofloxacin at percentages of 71.5%, 51.5%, 36.5%, 22.4%, and 14.7%, respectively. No imipenem-resistant strains were identified. 24.8% of the isolates exhibited multidrug resistance (MDR). Conclusion: S. typhimurium and S. enteritidis were the dominant serotypes in children (<2 years) with salmonella-infected arrhoea in Hangzhou, China. Ongoing serotype monitoring should be necessitated and dynamic changes in serotypes should be carefully examined to prevent the sudden outbreak of foodborne illness. Salmonella exhibits a higher rate of resistance to common antibiotics, and the risk of multidrug resistance should not be ignored. Therefore, clinicians should administer antibiotics judiciously according to the results of drug sensitivity tests.

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confidence: 99%

Epidemiology, Serotype and Resistance of Salmonella Isolates from a Children’s Hospital in Hangzhou, Zhejiang, China, 2006–2021

Yue¹,

Liu²,

Li³

et al. 2022

IDR

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“…For example, S. Hadar is a host-non-specific serotype that causes infection in both humans and animals. It has been identified previously in hospital outbreaks and confirmed as the fourth most frequently isolated Salmonella serovar in Germany (Weidebotjes et al, 1998;Deshpande et al, 2015). Furthermore, instances of multidrug resistance in S. Albany have increased in recent years (Doublet et al, 2003).…”

Section: Introductionmentioning

confidence: 85%

Identification of Novel Sensitive and Reliable Serovar-Specific Targets for PCR Detection of Salmonella Serovars Hadar and Albany by Pan-Genome Analysis

Shang

Chen

et al. 2021

Front. Microbiol.

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The accurate and rapid classification of Salmonella serovars is an essential focus for the identification of isolates involved in disease in humans and animals. The purpose of current research was to identify novel sensitive and reliable serovar-specific targets and to develop PCR method for Salmonella C2 serogroups (O:8 epitopes) in food samples to facilitate timely treatment. A total of 575 genomic sequences of 16 target serovars belonging to serogroup C2 and 150 genomic sequences of non-target serovars were analysed by pan-genome analysis. As a result, four and three specific genes were found for serovars Albany and Hadar, respectively. Primer sets for PCR targeting these serovar-specific genes were designed and evaluated based on their specificity; the results showed high specificity (100%). The sensitivity of the specific PCR was 2.8 × 101–103 CFU/mL and 2.3 × 103–104 CFU/mL for serovars Albany and Hadar, respectively, and the detection limits were 1.04 × 103–104 CFU/g and 1.16 × 104–105 CFU/g in artificially contaminated raw pork samples. Furthermore, the potential functions of these serovar-specific genes were analysed; all of the genes were functionally unknown, except for one specific serovar Albany gene known to be a encoded secreted protein and one specific gene for serovars Hadar and Albany that is a encoded membrane protein. Thus, these findings demonstrate that pan-genome analysis is a precious method for mining new high-quality serovar-targets for PCR assays or other molecular methods that are highly sensitive and can be used for rapid detection of Salmonella serovars.

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“…More commonly, Salmonella Hadar is associated with poultry 3 Case Reports in Veterinary Medicine and foodborne illness outbreaks in humans [21,22]. Nonetheless, a clinical disease outbreak has occurred in a human maternity and neonatal hospital ward in the United Kingdom [23]. Salmonella sp.…”

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confidence: 99%

“…An awareness of these risk factors will help guide individual biosecurity protocols to address these potential risks. In the report of Salmonella Hadar transmission in a human maternity ward [23], the index case was the mother of an admitted child with diarrhea and subsequent disease transmission was spread to 11 neonates over 3 months. Though predominantly neonates were infected, the duration of the outbreak suggested a difficulty in controlling disease propagation and a potential increased survivability of Salmonella Hadar in the environment despite routine hospital cleaning protocols [23].…”

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confidence: 99%

Atypical Salmonellosis in a Horse: Implications for Hospital Safety

Rothers

Hackett

Mason

et al. 2020

Case Reports in Veterinary Medicine

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A 17-year-old Quarter Horse mare was evaluated for colic of 24-hour duration. Clinical signs and diagnostic evaluation were consistent with duodenitis-proximal jejunitis. The horse’s clinical condition deteriorated despite medical treatment and was euthanized. Aerobic culture collected from small intestinal ingesta was positive for Salmonella enterica subsp. enterica serovar Hadar. Salmonella sp. is commonly implicated in nosocomial infections in equine veterinary hospitals usually through feces containing the organism. Considering Salmonella sp. was cultured from the jejunal luminal contents and the large volume of nasogastric reflux that was evacuated in this case, a perceived risk of Salmonella sp. transmission from infected gastric reflux to other hospitalized cases was realized. Infectious agent biosecurity precautions should be undertaken in horses with nasogastric reflux to prevent hospital-acquired transmission.

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Historical outbreak of Salmonella hadar

Cited by 4 publications

References 35 publications

Epidemiology, Serotype and Resistance of Salmonella Isolates from a Children’s Hospital in Hangzhou, Zhejiang, China, 2006–2021

Epidemiology, Serotype and Resistance of Salmonella Isolates from a Children’s Hospital in Hangzhou, Zhejiang, China, 2006–2021

Identification of Novel Sensitive and Reliable Serovar-Specific Targets for PCR Detection of Salmonella Serovars Hadar and Albany by Pan-Genome Analysis

Atypical Salmonellosis in a Horse: Implications for Hospital Safety

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