“…42 However, it should be noted that high energy levels (>0.12 mJ/mm 2 ) of SW induce irreversible alterations to the cell structure and organelles. 19,34,43,44 Low energy levels (<0.12 mJ/mm 2 ) of SW, in contrast, induce cell membrane modifications and functional changes, and conduct a series of cell signaling and activation of biological processes, such as cell proliferation, angiogenesis, peripheral nerve regeneration, increased cell permeability and anti-inflammation. 16,19,34,35 How LESW works LESWs have effects on induction of cell proliferation, angiogenesis, nerve regeneration, anti-inflammation and a temporary increase of membrane permeability, through the modulation of various mechanisms, depending on tissue type and condition.…”