Historical Development of the Ergot Therapy of Migraine

Rothlin, E

doi:10.1159/000228229

Cited by 24 publications

(18 citation statements)

References 2 publications

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“…163 Midwives used ergot as an herbal medicine during delivery long before Adam Lonicer recommended the use of three sclerotia (0.5 mg) of ergot for uterine atony in 1582. 171 Although early medicinal use included the treatment of pruritus, diabetes, hyperthyroidism, and psychosis, as well as a uterine stimulant during labor, the administration of ergot was restricted to the treatment of migraine headaches and postpartum hemorrhage by the 1950s. 169 In the early 19 th century, the use of ergot to induce labor was discouraged in Europe because of the increased incidence of uterine rupture, stillbirths, and maternal death.…”

Section: Historymentioning

confidence: 99%

Mycotoxins

2008

Medical Toxicology of Natural Substances

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Section: Historymentioning

confidence: 99%

Mycotoxins

2008

Medical Toxicology of Natural Substances

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“…Ergotamine tartrate was the first ergot alkaloid to be isolated from the ergot fungus, Claviceps purpurea [1], and DHE was synthesized from ergotamine [2]. DHE can exhibit effects similar to serotonin (5-hydroxytryptamime; 5-HT), with affinity for 5-HT1 receptors (subtypes B and D), as well as other biogenic amine receptors, such as 5-HT2 (subtypes B and C) [3], DA2 dopaminergic receptors [4] and α 1 -/α 2 -adrenergic receptors [5].…”

Section: Introductionmentioning

confidence: 99%

Dihydroergotamine Tartrate Induces Lung Cancer Cell Death through Apoptosis and Mitophagy

Chang¹,

Lee²,

Yu³

et al. 2016

Chemotherapy

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Background: Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. Methods: We examined the effect of DHE on the survival of several lung cancer cells and confirmed that DHE suppressed diverse lung cancer cell growth effectively. To confirm whether such effects of DHE would be associated with mitochondria, A549 cells were employed for the evaluation of several important parameters, such as membrane potential, reactive oxygen species (ROS) generation, apoptosis, ATP production and autophagy. Results: DHE decreased membrane permeability, increased ROS generation as well as apoptosis, and disturbed ATP production. Eventually, mitophagy was activated for damaged mitochondria. Conclusion: Taken together, our findings demonstrate that DHE induces lung cancer cell death by the induction of apoptosis and mitophagy, thus suggesting that DHE can be developed as an anti-lung cancer therapeutic agent.

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“…The first pure ergot alkaloid, ergotamine tartrate, was used to treat acute migraine as early as 1925. 6 Although ergotamine tartrate remained a common and effective treatment for decades, it aggravated the nausea and vomiting commonly associated with migraine, and it often provoked adverse effects related to vasoconstriction. The desire to reduce adverse effects led to the development of dihydroergotamine in 1945.…”

Section: Introductionmentioning

confidence: 99%