Mucosal Immunology 2015
DOI: 10.1016/b978-0-12-415847-4.02001-2
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Historical Aspects of Mucosal Immunology

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Cited by 5 publications
(4 citation statements)
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References 228 publications
(161 reference statements)
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“…Evidence for the intestine as a primary lymphoid organ was first demonstrated in birds which have the bursa of Fabricus in the cloaca (equivalent to rectum), which is responsible for their generation of B cells (reviewed in [163]. Similarities between the sacculus rotundus of rabbits and the bursa of birds originally prompted some to consider this massive B cell rich region of the rabbit intestine to be a primary lymphoid organ as well [163, 164]. More recently however, and with new technologies, the concept that GALT may contain primary lymphoid tissues capable of replenishing B cell follicles and possibly T cells is re-emerging.…”
Section: Intestinal Cd4+ T Cell Reconstitution After Hiv Infectionmentioning
confidence: 99%
“…Evidence for the intestine as a primary lymphoid organ was first demonstrated in birds which have the bursa of Fabricus in the cloaca (equivalent to rectum), which is responsible for their generation of B cells (reviewed in [163]. Similarities between the sacculus rotundus of rabbits and the bursa of birds originally prompted some to consider this massive B cell rich region of the rabbit intestine to be a primary lymphoid organ as well [163, 164]. More recently however, and with new technologies, the concept that GALT may contain primary lymphoid tissues capable of replenishing B cell follicles and possibly T cells is re-emerging.…”
Section: Intestinal Cd4+ T Cell Reconstitution After Hiv Infectionmentioning
confidence: 99%
“…Reciprocal interactions between host and microbiota contribute to tissue function and homeostasis and determine microbiota composition, thereby playing an important role in infection and disease (87). For example, members of the intestinal microbiota regulate production of antimicrobial peptides by Paneth cells (88) and shape immune responses by regulating numbers, subsets, and/or functions of T, B, and myeloid cells (65). Microbiota-induced changes in immunity also determine intestinal microbiota composition (85,89).…”
mentioning
confidence: 99%
“…Mucosal tissues contain an array of small molecules, including innate defense mediators that target pathogens and regulate downstream host defenses. Intestinal mucus harbors compounds from the innate and adaptive systems that protect against microbial insult, including digestive enzymes (e.g., lysozyme), lactoferrin, antimicrobial peptides, complement, and antibodies (e.g., secretory immunoglobulin A [sIgA]) (65). In addition, cells of the innate defense system respond to pathogenassociated molecular patterns (PAMPs) using pathogen recognition receptors (PRRs).…”
mentioning
confidence: 99%
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