Historical Aspects and Present Knowledge of Idiopathic Thrombocytopenic Purpura

Imbach, Paul; Kühne, Thomas; Signer, E

doi:10.1046/j.1365-2141.2002.03755.x

Cited by 36 publications

(29 citation statements)

References 27 publications

(25 reference statements)

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“…Bleedings ceased in all three patients who underwent splenectomy. Since then, splenectomy has become the mainstay for the treatment in adult patients with refractory ITP, laparoscopic approach being common recently [10]. His paper on splenectomy is ranked the top fifth in a citation analysis of articles appearing in Wiener Klinische Wochenschrift between 1945 and 1988 [11].…”

Section: Splenectomy For the Treatment Of Idiopathic Thrombocytopenicmentioning

confidence: 99%

Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology

Yoshida

2008

Ann Hematol

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Section: Splenectomy For the Treatment Of Idiopathic Thrombocytopenicmentioning

confidence: 99%

Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology

Yoshida

2008

Ann Hematol

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“…Paul Gottlieb Werlhof (1699-1767), oft als Erstbeschreiber der ITP genannt ("Morbus Werlhof "), hat 1735 bei einem 16-jährigen Mädchen eine Haut-und Schleimhautblutung beschrieben, die er als "Morbus maculosus haemorrhagicus" beschrieb [11]. Eduard Henoch (1820-1910) betonte die Bedeutung des Unterschieds zwischen trockener und feuchter Blutung (Purpura simplex und Purpura haemorrhagica).…”

Section: Historischer üBerblickunclassified

Idiopathische thrombozytopenische Purpura im Kindesalter

Kühne

Imbach

2006

Monatsschr Kinderheilkd

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“…ITP was first described by P. G. Werlhof in 1735 year, who called it "Morbus maculosus hemorrhagicus" [1]. ITPis an autoimmune hematological disease, characterized by splenic production of antibodies against platelet glycoprotein complexes, resulting in a variable degree of thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors for positive immune thrombocytopenic purpura outcome after laparoscopic splenectomy

Kiudelis¹,

Mickevičius²,

Dambrauskienė³

et al. 2010

Open Medicine

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AbstractLaparoscopic splenectomy is considered as a second step treatment for ITP patients. The purpose of this study was to determine efficiency of laparoscopic splenectomy for ITP patients and to identify the independent prognostic factors that may predict the positive outcome. Two hundred and thirty nine patient medical records were analyzed retrospectively. The special questionnaire, which included present platelet count, the steroid usage and its dosage, was sent to all patients. The complete response (CR) was defined, when the platelet count was above 130 × 109 /L. The 239 adult patients with a median age of 51.3 (16–93 years) were included in this cohort. The median follow up period was 75 months. 49 patients, who relapsed after steroid treatment, underwent laparoscopic splenectomy. The short term postoperative CR was 71.4% after laparoscopic splenectomy compared to 38.1% in non-splenectomized patients (p < 0.000). The long term CR was 79.5 % in patients after splenectomy compared to 47.4% in non-splenectomized patients (p < 0.018). After univaried analysis three clinical variables were found to be significantly related to splenectomy outcome: disease duration (p<0.007), preoperative platelet count (p<0.049) and platelet count on the third postoperative day (p<0.000). Multiple logistic regression analysis demonstrated, that only platelet count on the 3rd postoperative day > 129 × 109 /L; RR=53.3 95% (CI, 1.888–1517.98) was significant predictor for long-term positive ITP outcome after laparoscopic splenectomy. Splenectomy is effective treatment for ITP. Platelet count > 129 × 109/L on the third postoperative day is the significant predictor of positive long-term outcome after laparoscopic splenectomy.

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Historical Aspects and Present Knowledge of Idiopathic Thrombocytopenic Purpura

Cited by 36 publications

References 27 publications

Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology

Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology

Idiopathische thrombozytopenische Purpura im Kindesalter

Prognostic factors for positive immune thrombocytopenic purpura outcome after laparoscopic splenectomy

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