Histoplasmosis pulmonar crónica en un paciente no inmunodeprimido, residente 10 años antes en una zona endémica

García-Marrón, Manuel; García-García, José María; Pajín-Collada, Mercedes; Álvarez-Navascués, Fernando; Martínez-Muñiz, Manuel Ángel; Sanchez-Antuña, Andres

doi:10.1157/13126837

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Similar to pulmonary TB, chronic pulmonary histoplasmosis (usually Hcc) starts with malaise, fever, fatigue, cough, and sputum. However, sputum production, weight loss, and night sweat are less prominent than TB [ 47 ]. Eventually, chronic pulmonary histoplasmosis often results in pulmonary insufficiency and cor pulmonale.…”

Section: Histoplasmosis and Tbmentioning

confidence: 99%

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Histoplasmosis in Africa: An emerging or a neglected disease?

et al. 2018

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Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades , 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H. capsulatum var. capsulatum (Hcc). There have been 12 histoplasmin skin test surveys with rates of 0% to 35% positivity. Most cases of Hcd presented as localised lesions in immunocompetent persons; however, it was disseminated in AIDS patients. Rapid diagnosis of histoplasmosis in Africa is only currently possible using microscopy; antigen testing and PCR are not available in most of Africa. Treatment requires amphotericin B and itraconazole, both of which are not licensed or available in several parts of Africa.

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Section: Histoplasmosis and Tbmentioning

confidence: 99%

“…Eventually, chronic pulmonary histoplasmosis often results in pulmonary insufficiency and cor pulmonale. It rarely causes death if untreated, unlike TB at the advanced stage [ 47 , 48 ].…”

Section: Histoplasmosis and Tbmentioning

confidence: 99%

Histoplasmosis in Africa: An emerging or a neglected disease?

et al. 2018

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“…Most of the immunocompetent patients had pulmonary histoplasmosis (60/83, 73.2%), which was associated with rheumatological manifestations (arthralgia and/or erythema nodosum) in 23.3% of cases (Table 6). There were eight cases (13.3%) of single or multiple nodular lung lesions mimicking neoplasia or severe sarcoidosis [95,97,107,[119][120][121]128,133], three cases of chronic cavitary histoplasmosis [101,102,127], and one patient with fibrosing mediastinitis [130]. Five patients (6.2%) presented with a picture of PDH [103,116,123,125,126], and two showed central nervous system involvement [103,134].…”

Section: Immunocompetent Patientsmentioning

confidence: 99%

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Antinori

Giacomelli

Corbellino

et al. 2021

JoF

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Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been some autochthonous cases, especially in Italy; however, most European physicians are unfamiliar with its clinical and pathological picture, particularly among immunocompromised patients without HIV infection. This systematic review of all the cases of histoplasmosis reported in Europe and Israel between 2005 and 2020 identified 728 cases diagnosed in 17 European countries and Israel described in 133 articles. The vast majority were imported (mainly from Central and South America), but there were also seven autochthonous cases (six in Europe and one in Israel). The patients were prevalently males (60.4%), and their ages ranged from 2 to 86 years. The time between leaving an endemic region and the diagnosis of histoplasmosis varied from a few weeks to more than 40 years. Progressive disseminated histoplasmosis was the most frequent clinical picture among people living with HIV infection (89.5%) or a different immunocompromising condition (57.1%), but it was also recorded in 6.2% of immunocompetent patients. Twenty-eight cases were caused by Histoplasma duboisii. Immunocompromised patients without HIV infection had the worst outcomes, with a mortality rate of 32%.

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“…The infection might well remain asymptomatic in immunocompetent individuals, and progression of the disease is directly proportional to the immune status of the person. Predisposing factors for clinical infection with H capsulatum include patients of extreme ages (infants and elderly), recurrent respiratory tract infections, chronic alcoholism, haematological malignancies, patients who underwent solid organ transplantations, people receiving immunosuppressive drugs, patients with inborn T-cell immunodeficiency, and acquired immunodeficiency syndrome (AIDS) patients [ 5 - 6 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

Kandi¹,

Vaish²,

Palange³

et al. 2016

Cureus

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Histoplasmosis is a systemic fungal mycosis caused by Histoplasma capsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic. In the case of immunosuppression, clinical symptoms of pulmonary infection may be seen along with chances of dissemination. We report a case of chronic pulmonary histoplasmosis in an immunocompetent individual.

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Histoplasmosis pulmonar crónica en un paciente no inmunodeprimido, residente 10 años antes en una zona endémica

Cited by 8 publications

References 15 publications

Histoplasmosis in Africa: An emerging or a neglected disease?

Histoplasmosis in Africa: An emerging or a neglected disease?

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

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