Histoplasmosis

Kauffman, Carol A.

doi:10.1007/978-1-4419-6640-7_18

Cited by 19 publications

(26 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various presentations can be classified as acute pulmonary, chronic pulmonary and disseminated disease. [1] For the majority of immunocompetent patients, the disease is asymptomatic or presents with mild influenza-like symptoms which resolve without treatment in <4 weeks. [4] In those exposed to a high inoculum or in immunocompromised patients, acute severe pulmonary infection may occur, which can progress to acute respiratory distress syndrome and death.…”

Section: Discussionmentioning

confidence: 99%

“…[5] In the chronic disseminated form of the disease, seen in immunocompetent adults, pulmonary symptoms are often less prominent and lesions of the skin and mucous membranes are more common, particularly oropharyngeal ulcerations. [1] Laryngeal involvement occurs in the chronic disseminated form of histoplasmosis. Distinguishing laryngeal histoplasmosis from laryngeal carcinoma can be challenging, as in this case.…”

Section: Discussionmentioning

confidence: 99%

“…H. capsulatum then travels to mediastinal and hilar lymph nodes, from where it disseminates throughout the reticuloendothelial system of the host. [1] The main predisposing factors for histoplasmosis, particularly the disseminated form, include increasing age and decreasing cell-mediated immunity due to immunosuppressive agents. [2] Endemic fungal infections have been increasing in frequency in recent years, which may be related to increasing use of aggressive chemotherapeutic agents, organ transplantation, and use of immunosuppressive drugs for autoimmune or rheumatologic diseases.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Histoplasmosis of the larynx

2013

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histoplasmosis of the larynx

2013

View full text Add to dashboard Cite

show abstract

“…In the chronic disseminated form of the disease, seen in immunocompetent adults, pulmonary symptoms are often less prominent and lesions of the skin and mucous membranes are more common, particularly orophary n geal ulcerations. 7 Laryngeal involvement occurs in the chronic disseminated form of histoplasmosis. Dis tinguishing laryngeal histoplasmosis from laryngeal carcinoma can be challenging, as in this case.…”

Section: Discussionmentioning

confidence: 99%

Primary Histoplasmosis of Larynx Mimicking as Laryngeal Carcinoma

Shirazi¹,

Agrawal²,

Bharti³

et al. 2015

International Journal of Phonosurgery &Amp; Laryngology

View full text Add to dashboard Cite

Granulomatous diseases caused by infectious agents are being encounted more frequently nowadays. Infection by Histoplasma capsulatum is one such granulomatous disease. Isolated laryngeal histoplasmosis is a rare clinical entity. Because of its simulation with malignancy, it needs to be included in the differential diagnosis of neoplasm, both benign and malignant. We report an extremely rare case of isolated histoplasmosis, presenting as a primary infection of the larynx with no other systemic involvement in a 57 years old immunocompetent male. He presented with progressive hoarseness of voice, difficulty in breathing and mild dysphagia. Indirect laryngoscopy revealed multiple exophytic nodular lesions in endolaryngeal structures. The patient then underwent direct laryngoscopy biopsy under general anesthesia and the histopathological examination of the biopsy revealed chronic granulomatous inflammation, caused by histoplasma which was confirmed by using special Gomori's methanamine silver stain for fungi. Though it appeared like cancer clinically; biopsy confirmed the final diagnosis. The histopathologist must be informed about the possibility of histoplasmosis, because special dyes have to be used to confirm this diagnosis. The treatment is mainly medical with amphotericinB which remains the gold standard for treatment of this disease, although other drugs have also been used. How to cite this article Bist SS, Sandhirr S, Shirazi N, AgrawalV, Bharti B. Primary Histoplasmosis of Larynx Mimicking as Laryngeal Carcinoma. Int J Phonosurg Laryngol 2015;5(1):28-31.

show abstract

“…Most Histoplasma infections are subclinical, however, occasionally disease occurs linked in to the host immune response [4]. The disease is the most common pulmonary mycosis in North America and Central America, but the organism is known to exist in many areas around the world [5][6][7][8][9]. Histoplasmosis usually presents as in immune-compromised individuals with serious underlying disease, including AIDS [10,11].…”

Section: Introductionmentioning

confidence: 99%