Histoplasmosis as cause of penile ulcer in acquired immune deficiency syndrome (AIDS): three case reports

Oliveira, Ederson Valei Lopes de; Miduati, Fernanda Belluci; Antônio, Joäo Roberto; Moraes, Rafael de Negreiros; Almeida, Margarete Teresa Gottardo de; D’ávilla, Solange Correa Garcia Pires; Pozetti, Eurides Maria de Oliveira

doi:10.1007/s11046-007-9073-0

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…The majority of patients with disseminated histoplasmosis are immunocompromised; however, disseminated histoplasmosis also occurs in apparently immunocompetent patients. Although the most commonly described pattern of cutaneous involvement features multiple papules on the face, trunk and upper extremities, a broad range of dermatologic manifestations has been documented …”

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confidence: 99%

Cutaneous presentation of disseminated histoplasmosis as a solitary peri‐anal ulcer. Case report and discussion

et al. 2016

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Disseminated histoplasmosis has a diverse and non-specific range of clinical signs and symptoms. In a significant minority of patients, cutaneous lesions are apparent at the time of initial presentation, affording an opportunity to establish the diagnosis from a skin biopsy. The most frequently reported clinical scenario in immunocompromised patients with cutaneous involvement is that of multiple papulo-nodular lesions on the face, trunk or extremities. The following report features an immunocompetent patient who presented with a solitary ulcerated plaque on the buttocks close to the anal verge. This case presentation underscores the broad spectrum of clinical presentations as well as the potential for diagnostic confusion with protozoa such as Leishmania or Trypanosoma species during histopathologic examination if special stains for fungal organisms are not performed.

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confidence: 99%

Cutaneous presentation of disseminated histoplasmosis as a solitary peri‐anal ulcer. Case report and discussion

et al. 2016

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“…Although female genital histoplasmosis is very rare, multiple accounts of penile lesions caused by the fungus have been reported. 2,5,6 The etiology behind the gender difference is unknown. Fungal culture is the diagnostic gold standard.…”

Section: Commentmentioning

confidence: 99%

“…Pyoderma gangrenosum is most often found in patients with underlying inflammatory bowel disease. 1,2 The mainstay of vulvar pyoderma gangrenosum treatment in the literature has been steroid therapy. [3][4][5][6] However, cyclosporine has been used to effectively treat pyoderma gangrenosum located on other areas of the body.…”

Section: Casementioning

confidence: 99%

“…The impaired cellular defense in patients with human immunodeficiency virus (HIV) and the rich blood supply of the skin and mucous membranes allow for relatively easy seeding of infections. 2 Progressive disseminated histoplasmosis can be fatal if left untreated. We present a case of a woman with progressive disseminated histoplasmosis presenting as an ulcerated vulvar lesion.…”

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confidence: 99%

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Vulvar Histoplasmosis as a Rare Cause of Genital Ulceration

Shine

Shah²,

Hanna³

et al. 2013

Obstetrics &Amp; Gynecology

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“…In non-human immunodeficiency virus (HIV)+ immunocompromised patients, a disseminated form of the infection is observed. [1][2][3] HIV+ immunocompromised patients can show a wide spectrum of dermatological lesions, from erythematous plaques 4,5 ; maculopapules; crusted, 6 verrucous, 7,8 or desquamative papules and nodules 9,10 ; abscesses; mucocutaneous ulcers 11 ; cellulitis to acneiform or varicelliform lesions and some molluscum contagiosum-like lesions. In this polymorphism, the histopathology is crucial for the diagnosis to confirm the presence of the microorganism.…”

Section: Introductionmentioning

confidence: 99%

New Clinical and Histological Patterns of Acute Disseminated Histoplasmosis in Human Immunodeficiency Virus–Positive Patients With Acquired Immunodeficiency Syndrome

Sierra¹,

Torres²

2013

The American Journal of Dermatopathology

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Histoplasmosis has attained increasing relevance in the past 3 decades because of the appearance of the human immunodeficiency virus (HIV). In most immunocompetent persons, the infection is asymptomatic or can produce a respiratory condition with symptoms and radiological images similar to those observed in pulmonary tuberculosis; in non-HIV+ immunocompromised patients, it can cause respiratory symptoms or evolve into a disseminated infection. The same can occur in acquired immunodeficiency syndrome (AIDS) patients. We have observed a series of HIV+ patients with AIDS who presented with cutaneous histoplasmosis and in whom the clinical and histopathological features were highly unusual, including variable mucocutaneous lesions that were difficult to diagnose clinically. These patients displayed unusual, previously undescribed, histological patterns, including lichenoid pattern, nodular pseudomyxoid pattern, pyogenic granuloma-like pattern, perifollicular pattern, and superficial (S), mid (M), and deep perivascular dermatitis; and more commonly encountered patterns, such as histiocytic lobular panniculitis and focal nodular dermatitis. The novel histopathological patterns of cutaneous involvement by histoplasmosis seen in these patients resembled other common inflammatory and infectious conditions and required a high level of suspicion and the application of special stains for organisms for confirmation. These new, clinical, and histological findings do not seem to be commonly encountered in HIV- patients infected with the fungus but seem to be displayed most prominently in HIV+ patients with AIDS.

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Histoplasmosis as cause of penile ulcer in acquired immune deficiency syndrome (AIDS): three case reports

Abstract: The cases reported herein are to illustrate the plurality of pathologies and clinical manifestations, which may affect immunocompromised patients. The correct diagnosis of fungal diseases in these patients following well established treatment will improve the prognosis.

Cited by 8 publications

References 13 publications

Cutaneous presentation of disseminated histoplasmosis as a solitary peri‐anal ulcer. Case report and discussion

Cutaneous presentation of disseminated histoplasmosis as a solitary peri‐anal ulcer. Case report and discussion

Vulvar Histoplasmosis as a Rare Cause of Genital Ulceration

New Clinical and Histological Patterns of Acute Disseminated Histoplasmosis in Human Immunodeficiency Virus–Positive Patients With Acquired Immunodeficiency Syndrome

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