Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review

Basso, Rossana Patrícia; Poester, Vanice Rodrigues; Silveira, Jussara María; Vieira, Roseli Stone; Mota, Luísa Dias da; Klafke, Gabriel Baracy; Müller, Jéssica Nunes; Penna, Crislaine Padilha; Vianna, Júlia Silveira; Busatto, Caroline; Silva, Pedro Eduardo Almeida da; Ramis, Ivy Bastos; Stevens, David A.; Xavier, Melissa Orzechowski

doi:10.1016/j.mmcr.2020.04.001

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…In another coinfection case by C. glabrata, M. monocense and other bacteria, voriconazole was administered together with cefoperazone, sulbactam and linezolid, an improvement in the patient's conditions being observed after 10-days therapy [125]. In a previously mentioned report by Basso and colleagues, the treatment of a patient with HIV infection and histoplasmosis was described [154]. The regimen was complex including several antifungal drugs over time (intravenous amphotericin B deoxycholate, itraconazole, itraconazole), antiretroviral (tenofovir, lamivudine, efavirenz) and antibacillar drugs (sulfamethoxazole-trimethoprim, clarithromycin, ETB, streptomycin and levofloxacin).…”

Section: Treatment: Major Challenges and Future Perspectivesmentioning

confidence: 98%

“…This was the case of histoplasmosis that only in 1985 was taken into account for the definition of AIDS by the Centers for Diseases Control and Prevention (CDC) [150]. Curiously, all but one of the H. capsulatum-NTM coinfections reported in Table 1 are cases of disseminated infections in AIDS patients, M. avium being the predominant NTM [136,[151][152][153][154][155] and M. sherrisii the other NTM [156]. In Table 1, several cases of coinfection by MAC and H. capsulatum are presented, whereas other pathogens such as E.coli [152], herpes virus and Pneumocystis jirovecii [153] were isolated.…”

Section: Coinfection By Ntm and Fungimentioning

confidence: 99%

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Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

2020

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Nontuberculous mycobacteria (NTM) and many fungal species (spp.) are commonly associated with opportunistic infections (OPIs) in immunocompromised individuals. Moreover, occurrence of concomitant infection by NTM (mainly spp. of Mycobacterium avium complex and Mycobacterium abscessus complex) and fungal spp. (mainly, Aspergillus fumigatus, Histoplasma capsulatum and Cryptococcus neoformans) is very challenging and is associated with poor patient prognosis. The most frequent clinical symptoms for coinfection and infection by single agents (fungi or NTM) are similar. For this reason, the accurate identification of the aetiological agent(s) is crucial to select the best treatment approach. Despite the significance of this topic it has not been sufficiently addressed in the literature. This review aims at summarizing case reports and studies on NTM and fungi coinfection during the last 20 years. In addition, it briefly characterizes OPIs and coinfection, describes key features of opportunistic pathogens (e.g., NTM and fungi) and human host predisposing conditions to OPIs onset and outcome. The review could interest a wide spectrum of audiences, including medical doctors and scientists, to improve awareness of these infections, leading to early identification in clinical settings and increasing research in the field. Improved diagnosis and availability of therapeutic options might contribute to improve the prognosis of patients’ survival.

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Section: Treatment: Major Challenges and Future Perspectivesmentioning

confidence: 98%

Section: Coinfection By Ntm and Fungimentioning

confidence: 99%

Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

2020

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“…A coinfecção entre HIV e Histoplasma capsulatum pode ser explicada pelo imunocomprometimento causado pelo vírus, o que torna os pacientes mais suscetíveis à infecções concomitantes (Carreto-Binaghi et al,2019) Além disso, uma infecção pode causar o estabelecimento de outras infecções. Indivíduos imunossuprimidos podem ter múltiplas infecções oportunistas coexistindo (Anot et al, 2020;Basso et al, 2020).…”

Section: Coinfecção Hiv Histoplasma Capsulatum E Outros Microrganismos Oportunistasunclassified

“…Pneumocystis jirovecii (Carreto-Binaghi et al, 2019), Rhodococcus equi (Lambaré, Benítez, Taboada, Samaniego, & Sanabria, 2016), Mycobacterium avium (Basso et al, 2020), infecção micobacteriana (Samayoa et al, 2017), infecção micobacteriana não tuberculosas disseminada (Choi et al, 2019).…”

Section: Coinfecção Hiv Histoplasma Capsulatum E Outros Microrganismos Oportunistasunclassified

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Coinfecção entre HIV e Histoplasma capsulatum

Bezerra

Júnior

Oliveira

et al. 2021

RSD

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A histoplasmose é uma doença endêmica causada por Histoplasma capsulatum. A coinfecção entre HIV e H. capsulatum faz com que os pacientes estejam sob alto risco de desenvolver a forma disseminada da doença com alta letalidade. O objetivo deste estudo foi realizar um levantamento contendo as últimas descobertas ou pesquisas conduzidas nos últimos anos sobre a coinfecção. Trata-se de uma revisão integrativa, onde foram utilizadas as plataformas PubMed, SciELO e LILACS. Foram cruzados com o operador booleano OR e AND os descritores: “HIV”, “AIDS”, “Coinfection”, “Histoplasma” e “Histoplasmosis” em inglês, português e espanhol. Os critérios de inclusão foram: artigos na íntegra publicados entre 2016 a 2021. Os critérios de exclusão foram: artigos duplicados, resenhas, anais de congresso, artigos de revisão, opinião ou reflexão, editoriais, artigos que não abordaram o tema e publicados fora do período de análise. Foram selecionados 25 artigos. Em relação à temática dos artigos, 68% são estudos sobre a prevalência/incidência da coinfecção, 20% tratam das manifestações clínicas, 8% são estudos de métodos diagnósticos e 4% tratam da diversidade genética de Histoplasma encontrada em pacientes HIV. Não houve nenhum estudo sobre tratamento da coinfecção. Quanto a origem, 68% dos artigos são de países da América Latina. Esta revisão possibilitou traçar um panorama sobre os últimos estudos publicados a respeito da coinfecção. Percebe-se a ausência de estudos com enfoque no tratamento e faz-se necessário intensificar pesquisas neste aspecto e realizar inquéritos sorológicos para determinar a prevalência real da Histoplasmose pois ainda é uma doença relacionada à AIDS amplamente subdiagnosticada.

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A Challenging Case with HIV/AIDS and a Multisystem Disease

Sellamuthu,

Soni,

Gopalakrishnan

2024

Journal of Clinical Infectious Disease Society

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We report a case of 47 year old male from a rural area in Bihar with fever of 1 month duration, dry cough, weight loss and loss of appetite. He also had papular rash on the face. His laboratory investigations were notable for bicytopenia and elevated creatinine levels. He also had transaminase elevation, albumin globulin reversal and markedly elevated alkaline phosphatase, GGT levels. Ferritin and LDH were markedly elevated. Chest X ray and USG Abdomen revealed normal study. Bone marrow biopsy revealed the diagnosis. Eventually an unusual co infection was identified.

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Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review

Cited by 3 publications

References 17 publications

Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

Opportunist Coinfections by Nontuberculous Mycobacteria and Fungi in Immunocompromised Patients

Coinfecção entre HIV e Histoplasma capsulatum

A Challenging Case with HIV/AIDS and a Multisystem Disease

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