Histopathology of tubal pregnancy

Abstract

The histopathological examination of several sections of tubal ectopic pregnancies shows that the growth of the trophoblast usually takes place in an extraluminal subperitoneal site and dilation of the tube is caused by coagulated blood and not by the trophoblast. For conservative surgery of the tube it is necessary to keep in mind the histopathological findings of tubal pregnancies.

A second trimester live tubal ectopic pregnancy: a case report

“…8 In the remainder ,the trophoblast penetrates the tubal wall and proliferates in the loose connective tissue between the muscularis and the serosa. [8][9][10] In most cases, the characteristics segmental dilation of the tubal ampulla is composed mostly of coagulated blood rather than trophoblastic tissue. 8 In contrast, ectopic implantations in the tubal isthmus typically penetrate the tubal wall relatively early, probably because the more muscular segment is less distensible.…”

Significance of Trophoblastic Infiltration Into the Tubal Wall in Ampullary Pregnancy

“…The extension of the implantation site varies among cases, ranging from superficial involvement of the mucosal area to involvement of the total transmural location. 5,6 The mechanisms that may contribute to the limitation of trophoblast extension are unclear. Additionally, no validated criteria exist for the prediction of the depth of trophoblastic infiltration into the tubal wall in EP.…”

Avaliação da expressão das metaloproteinases e de seus inibidores no sítio de implantação trofoblástica em gestações ectópicas ampulares

“…Existe divergência, entre os autores dos principais estudos, em relação à histopatologia da invasão trofoblástica na GE. Enquanto alguns a consideram superficial, com lesão de mucosa e distensão do lúmen tubário (Stock, 1985;Pauerstein et al, 1986;Senterman et al, 1988;Stock, 1991), outros entendem que a invasão é mais agressiva seguindo-se, à penetração na mucosa, o acometimento de camadas mais profundas (Budowick et al, 1980;Randall et al, 1987, Dietl et al, 1988. (Daniel et al, 1999;Felembam et al, 2002;Mueller et al, 2004).…”

“…Entretanto, poucos estudos foram publicados, desde então, com esse tema específico. Existe investigação sobre a relação entre concentração sérica das MMPs e alguns desfechos obstétricos adversos (Dietl et al, 1988;Ke et al, 2006;Kocarslan et al, 2015;Chen;Khalil, 2017;Feng et al, 2017), dentre os quais a GE (Bjørn et al, 1997;Kucera et al, 2000;Bai et al, 2005;Qiu et al, 2011;Rajtar-Ciosek et al, 2016;Senapati et al, 2016), além de estudos sobre a expressão dessas proteínas na interface trofoblasto-decídua (Hurskainen et al, 1996;Qin et al, 1997;Huppertz et al, 1998;Hurskainen et al, 1998;Goldman et al, 2003;Anacker et al, 2011)…”