Histopathology of the synovial membrane of peripheral joints in ankylosing spondylitis.

Abstract

SUMMARY The histological features of the synovial membrane of peripheral joints in ankylosing spondylitis are similar to those seen in rheumatoid arthritis. There is intimal cell hyperplasia, a diffuse lymphocyte and plasma cell infiltrate, and formation of lymphoid follicles. Peroxidaseantiperoxidase staining shows the presence of IgG-, IgA-, and IgM-containing plasma cells in ankylosing spondylitis. The percentage of IgM-containing cells is significantly lower in ankylosing spondylitis than in rheumatoid arthritis.The histology of the synovial membrane of peripheral joints in ankylosing spondylitis has been examined in a small series of cases by Cruickshank,' Julkunen,2 and Wagner3 and the appearances found to be basically similar to those of rheumatoid arthritis. Geiler4 and Fassbender5 also gave descriptions, but did not formally examine a series of biopsies.Immunohistochemical methods have previously been applied to the rheumatoid synovium by numerous workers,6-"7 but these methods have not been used in the other arthritides except for occasional cases.9 17 18We have obtained histological sections of synovial membrane from ankylosing spondylitics and wish to report our findings using routine staining techniques and the peroxidase-antiperoxidase (PAP) immunohistochemical method for the detection of immunoglobulin subclasses in plasma cells present in the synovial membrane. A series of rheumatoid synovial membranes have been examined for comparison.The PAP method enabled accurate identification of the site of immunoglobulin, which is not possible with the fluorescent methods used by previous workers. Materials and methodsA series of 14 samples of synovial tissue from ankylosing spondylitis was obtained from the London Hospital or kindly sent by colleagues at other centres. These samples were derived from synovial biopsies at the time of synovectomy or joint replacement. Synovial membrane has also been studied from 14 cases of

Radiographic Evidence of Hip Joint Recovery in Patients with Ankylosing Spondylitis after Treatment with Anti-tumor Necrosis Factor Agents: A Case Series

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Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis

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Rol' glyukokortikoidovv lechenii spondiloartritov

“…Существенных гистологических особенностей синовита при СПА по сравнению с синовитом при РА, как правило, не отмечается. Наблюдаются гиперплазия поверх-ностного слоя синовиальной оболочки, диффузная лимфо-цитарная и плазматическая инфильтрация и образование лимфоидных фолликулов, повышенная васкуляризация [3]. Однако результаты отдельных исследований отличаются.…”

“…Главным достоинством эторикоксиба является высокий уровень безопасности в отношении желудочно-кишечного тракта (ЖКТ), что доказано в большом числе РКИ, часть из которых плацебоконтролируемые, и соответствующем ме-таанализе, а также двух масштабных «эндоскопических» ис-следованиях [3,4]. Поскольку эторикоксиб относится к вы-сокоселективным НПВП (коксибам), огромное внимание исследователей было приковано к проблеме осложнений со стороны сердечно-сосудистой системы.…”