Histopathology of nonspecific granulomatous prostatitis with special reference to eosinophilic epithelial metaplasia: Pathophysiologic, diagnostic and differential diagnostic correlations

Dikov, Dorian; Koleva, Maria; Boivin, Jean-Francois; Lisner, Tomo; Belovezhdov, Veselin; Sarafian, Victoria

doi:10.4103/ijpm.ijpm_568_18

Cited by 3 publications

(9 citation statements)

References 23 publications

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“…Diagnosis of GP is histological and it is paid attention to the differential diagnosis with high Gleason score PCa and associated HG-HP. 4,5 An immunohistochemical panel has been proposed for the differential diagnosis of GP with high Gleason score PCa. 12,13 PD-L1 expression is rare in primary PCa, which has been hypothesized to be due to the poor immunogenicity of PCa, as PD-L1 expression is thought to be responsive to antitumour immunity.…”

Section: Discussionmentioning

confidence: 99%

“…The results of the present study show a lack of significant stromal PD-L1 expression in HG-HP, which is a constant accompanying finding in GP. 5 Therefore, in the setting of histopathological diagnosis and differential diagnosis of GP, PD-L1 is useful for identifying prostatic epithelioid granulomatous lesions even at low microscopic magnification, which is sometimes difficult by standard histological observation alone, especially in the cases with accompanying HG-HP. 5 On the other hand, in the recently described PD-L1-positives LEL in non-granulomatous HG-HP, the expression of PD-L1 is localized selectively in the ductal cells, and, unlike GP, an expression in the interstitial HG-inflammatory infiltrate was not detected.…”

Section: Discussionmentioning

confidence: 99%

“…5 Therefore, in the setting of histopathological diagnosis and differential diagnosis of GP, PD-L1 is useful for identifying prostatic epithelioid granulomatous lesions even at low microscopic magnification, which is sometimes difficult by standard histological observation alone, especially in the cases with accompanying HG-HP. 5 On the other hand, in the recently described PD-L1-positives LEL in non-granulomatous HG-HP, the expression of PD-L1 is localized selectively in the ductal cells, and, unlike GP, an expression in the interstitial HG-inflammatory infiltrate was not detected. 7 In conclusion, we have shown, for the first time, that epithelioid granulomatous and diffuse inflammatory infiltrates in GP express selectively high levels of PD-L1.…”

Section: Discussionmentioning

confidence: 99%

“…The morphologic and semiquantitative analysis of the intensity of HP was performed using a simplified grading system, known from our previous studies. 5,7 The highest grade was recorded for cases with varying intensity of the inflammatory infiltrate. 7 The age of the control groups of patients ranged from 53 to 65 years (mean: 60.1 years).…”

Section: Methodsmentioning

confidence: 99%

“…The histologic differential diagnosis of GP is made with high Gleason score prostatic adenocarcinoma (PCa) 4 and chronic nonspecific prostatic inflammation, which always accompanies GP and always is of high histologic grade (HG). 5 Programmed cell death protein 1 and its ligand (PD-L1) expression is induced at the surface of immune and epithelial cells of healthy and tumor tissues in response to various cytokines.…”

Section: Introductionmentioning

confidence: 99%

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Strong PD‐L1 expression in granulomatous prostatitis

et al. 2023

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BackgroundThe expression of programmed cell death ligand protein (PD‐L1) is weakly investigated in non‐tumoral and inflammatory prostatic pathology. The diagnosis of granulomatous prostatitis (GP) rests on the recognition of localized or diffuse epithelioid granulomatous inflammation in prostatic tissue which is frequently difficult by conventional histological observation alone. PD‐L1 expression in GP is not well studied so far.MethodsWe studied PD‐L1 expression in 17 GP cases (9 nonspecific GP, 5 Bacillus Calmette‐Guérin induced prostatitis, 1 prostatic tuberculosis, and 3 cases of postsurgical prostatic granulomas). The control group included 10 radical prostatectomies of patients with high Gleason score prostate adenocarcinoma (PCa) and National Institutes of Health‐category IV prostatitis (high‐grade histologic prostatitis; HG‐HP).ResultsAll of the GP cases showed easily visible strong membranous PD‐L1 expression (high levels of combined positive score) in localized and diffuse epithelioid granulomatous prostatic inflammation. None of the control cases showed the presence of significant PD‐L1 expression in inflammatory infiltrates in HG‐HP, tumor parenchyma, and stroma in PCa.ConclusionsThe study presents the first attempt to examine PD‐L1 expression in GP. Granulomatous inflammation in GP is easily identified when stained with PD‐L1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Strong PD‐L1 expression in granulomatous prostatitis

et al. 2023

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The Clinical Reality of Granulomatous Prostatitis

Hanssen,

Vrij,

Heesakkers

2024

Curr Bladder Dysfunct Rep

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Purpose of Review Granulomatous prostatitis is a rare inflammatory disease of the prostate. It is challenging for the clinician because it mimics prostate cancer and cannot be distinguished from prostate cancer clinically, biochemically, or radiologically. Granulomatous prostatitis can only be diagnosed by histopathological examination. To prevent overdiagnosis and overtreatment, it is an important disease to recognize. Recent Findings There are multiple case reports and studies describing granulomatous prostatitis. Summary This review aims to give an overview regarding the epidemiology, etiology, clinical presentation, diagnosis, and treatment of granulomatous prostatitis using (recent) literature.

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Eosinophilic Metaplasia in the Epididymis in Association With Lipofuscin Pigment: A Case Report

Gerakova¹

2023

Cureus

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We present the case of a 54-year-old man with a cystic formation measuring 0.6 cm in the head of the epididymis. Histologically, the lesion showed intense granular eosinophilic transformation of the cytoplasm. The finding was assessed as eosinophilic metaplasia (EM) and showed association with and deposition of lipofuscin pigment. The EM in the epididymis presents a sign of intracytoplasmic lysosomal accumulation, which serves as a microscopic indicator of ductal obstruction. The presented unique finding was compared with the data reported in the literature. In this case report, we describe an extremely rare metaplastic lesion in the epididymis.

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Histopathology of nonspecific granulomatous prostatitis with special reference to eosinophilic epithelial metaplasia: Pathophysiologic, diagnostic and differential diagnostic correlations

Cited by 3 publications

References 23 publications

Strong PD‐L1 expression in granulomatous prostatitis

Strong PD‐L1 expression in granulomatous prostatitis

The Clinical Reality of Granulomatous Prostatitis

Eosinophilic Metaplasia in the Epididymis in Association With Lipofuscin Pigment: A Case Report

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