Histopathology of Endometrial Curettings in Perimenopausal Women With Abnormal Uterine Bleeding

Chitra, Thukkaram; Manjani, Sekar; Madhumittha, Ramamurthy; B, Arun Harke; Saravanan, Ekambaranathan; Karthik, Sigamani; Shabana, Balakrishnan

doi:10.14260/jemds/2016/301

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…In Tukaram et al study functional causes contributed to 41 (55%) of cases and organic lesions contributed to 33 (45%) of cases. 16 In the study conducted by Singh et al PALM and COEIN accounted for 60% and 39.9% respectively unlike our study. 15 In the study conducted by Kalambe et al PALM contributed to 57.5% and COEIN to 42.5% cases.…”

Section: Resultscontrasting

confidence: 71%

Histopathological evaluation of endometrial sampling in perimenopausal women with abnormal uterine bleeding

Nair¹,

Kuriakose²

2021

Int J Reprod Contracept Obstet Gynecol

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Background: Abnormal uterine bleeding (AUB) is one of the common symptoms in the gynaecology outpatient department. About one third of women are affected at some time in their lives. The perimenopausal women show significant number of underlying organic pathology. The evaluation of endometrium and/or organ histopathology has the dual advantage of finding the cause of AUB and to rule out endometrial cancer or the potential for cancer in future like endometrial hyperplasia with atypia. The aim of the study was to determine the histopathological pattern of endometrial sampling in perimenopausal women with AUB and to follow them up for a period of six months after the procedure.Methods: The prospective observational study was conducted at the department of obstetrics and gynaecology at Sree Gokulam Medical College and Research Foundation, Venjaramood, Thiruvananthapuram, Kerala, for a period of one year from December 2019 to December 2020. The study was conducted on 116 perimenopausal women 41-52 years who presented with AUB and had undergone endometrial sampling. These ladies were subsequently followed up for six months post procedure to assess the response to medical treatment or the need for any surgical intervention like hysterectomy.Results: A total 39.65% patients had heavy and prolonged menstrual bleeding and 18.16% patients had irregular bleeding. 14.65% patients had prolonged flow, 8.6% had heavy flow, 6.8% had infrequent with prolonged flow, 6% had prolonged, infrequent with heavy bleeding. Non-structural (COEIN) causes contributed to about 60.4% of AUB in perimenopausal women and 39.6% had structural (PALM) causes. 49% cases were secretory endometrium. 29.3% had disordered proliferative endometrium, 4.3% had proliferative endometrium, 5.2% each had polyp or hyperplasia without atypia. 18 (15.5%) cases underwent hysterectomy, 3 patients who had adenocarcinoma underwent staging laparotomy, 2 patients had LNG IUS insertion and 40 patients were on follow up requiring either no treatment and 53 (45.68%) patients were given antifibrinolytics or hormonal therapy.Conclusions: Heavy and prolonged menstrual bleeding was the most common presenting symptom. COEIN contributed to about 60.4% of cases. Evaluation of the endometrium showed that, secretory endometrium was commonest (49%) followed by disordered proliferative endometrium (29.3%). On follow up for six months, 15.5% patients underwent hysterectomy, 2 patients had insertion of levonorgestrel IUD, 45.68% patients had medical management with antifibrinolytics or hormones and were on follow up. The responsibility of gynaecologist in the management of AUB in perimenopausal women is to exclude hyperplasia of endometrium and endometrial cancer.

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Section: Resultscontrasting

confidence: 71%

Histopathological evaluation of endometrial sampling in perimenopausal women with abnormal uterine bleeding

Nair¹,

Kuriakose²

2021

Int J Reprod Contracept Obstet Gynecol

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“…In the present study menorrhagia was the most common bleeding pattern which accounted for 65.5% which is comparable to 42.16% menorrhagia incidence reported by Jain M et al ,49% reported by Lotha et al,83.7% reported by Sreelakshmi U et al, 72% reported by Gupta et al ,45% reported by Das et al and 46.4% reported by Zeeba S et al[5][6][7][8] …”

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confidence: 81%

The Menstrual Pattern of Aub in Perimenopause

Jamwal¹,

Rao

2021

IJMBS

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Background: The Menstrual pattern of AUB in perimenopause. Methods: Prospective interventional study conducted at Kamla Nehru Hospital for State Mother and Child, IGMC Shimla. Results: Menorrhagia was the most common presentation of AUB patients accounting for 65.5% of cases with confidence interval of 58.96-71.64% followed by continuous bleeding per vagina(BPV) accounting for 17.9% with confidence interval of 13.17-23.49% with the least being oligomenorrhea 0.87% with confidence interval of 0.11-3.12%. Conclusion: Abnormal uterine bleeding in perimenopausal patients is a common and important part of clinical practice for health-care providers of women. Keywords: AUB, Menstrual pattern, Bleeding

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“…Abnormal Uterine Bleeding (AUB) is defined as any uterine bleeding that is more than the normal volume, of longer duration and varying in regularity or frequency [1]. AUB is a collective terminology that includes both organic and non-organic causes.…”

Section: Introductionmentioning

confidence: 99%

Histomorphological patterns of endometrium in abnormal uterine bleeding

Murugan

Ramachandran

Inbasekaran

2019

Trop J Pathol Microbiol

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Background: Abnormal uterine bleeding (AUB) is a common gynecological complaint, for which histopathological examination of endometrium is the gold standard tool in diagnostics. Aim of this study is to analyze various histomorphological patterns of endometrium in patients belonging to various age groups with abnormal uterine bleeding. Materials and Methods: A retrospective study of 174 patients presenting with abnormal uterine bleeding underwent endometrial sampling during a period of 2 years from September 2017 to August 2019 at VMKVMCH, Department of Pathology, were analyzed. Endometrial tissue received by sampling procedures such as dilatation and curettage (D & C), endometrial biopsy and fractional curettage were all submitted entirely for processing in the Department of Pathology. Patient data were collected, and slides were reviewed. Result: A total of 174 cases were analyzed. Patients' age ranged from 15 to 65 years. The predominant endometrial finding was proliferative endometrium 54 cases (31%) followed by secretory endometrium 50 cases (28.7%). Malignant lesions were seen in 5 cases (2.87%) in patients more than 49 years of age. Among the organic causes, polyps were the commonest 8 cases (4.59%). Adequate samples were obtained from 91% of cases while 9% of cases' samples were inadequate for opinion. Conclusion: Histopathological examination of endometrial samples should be done in patients with abnormal uterine bleeding, especially in women over 35 years of age to rule out malignancy and preneoplasia. Patients with no organic pathology had normal physiological patterns like proliferative endometrium, secretory endometrium and menstrual changes. Most common endometrial pathology in this series was endometrial polyp 8 cases (4.59%).

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Histopathology of Endometrial Curettings in Perimenopausal Women With Abnormal Uterine Bleeding

Abstract: BACKGROUNDAbnormal Uterine Bleeding (AUB) is one of the common complaints in the Gynaecology Outpatient Department. Endometrial sampling by dilatation and curettage is done to find out the aetiology of AUB in perimenopausal women.

Cited by 4 publications

References 8 publications

Histopathological evaluation of endometrial sampling in perimenopausal women with abnormal uterine bleeding

Histopathological evaluation of endometrial sampling in perimenopausal women with abnormal uterine bleeding

The Menstrual Pattern of Aub in Perimenopause

Histomorphological patterns of endometrium in abnormal uterine bleeding

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