Histopathology of cutaneous squamous cell carcinoma

Introduction to Skin Cancer

“…Other features, including the presence of perineural or vascular involvement, are typically reported. Subtypes described include spindle cell, acantholytic, verrucous, adenoid, clear cell, signet-ring cell, and basaloid [26,62,63]. Histopathologic features have been used to help predict prognosis of SCC.…”

A Primer of Mohs Micrographic Surgery: Common Indications

“…Tumors arising at sites of chronic scarring (mostly SCCs) due to radiodermatitis, osteomyelitis, and ulcers, among others, are considered very aggressive. These tumors are considered high risk due to their increased rate of metastases, and require MMS 3,6,11,12 …”

“…It usually affects younger patients and may present with multiple SCC lesions. These tumors are very aggressive and have a higher rate of metastases, thus requiring management with MMS 3,6,10–12 …”

“…Perineural invasion is more common in SCC than BCC and carries a high risk of recurrence and metastases. Patients with tumors that have perineural spread are often asymptomatic; however, symptoms may be present, including pain and paresthesias 3,4,12,13 . According to Rowe et al, 11 SCC with perineural spread s a local recurrence rate of 47.2% and a metastatic rate of 47.3%.…”

“…Epidermal dysplasia and keratinocytes disorganization is seen. Loss of polarity of the keratinocytes with hyperchromatic and multinucleated nuclei may also be seen 3,12,20 …”