Histopathology of chronic hepatitis C in relation to virus genotype

Delic, Dragan; Nesic, Zorica; Prostran, Milica; Boričić, Ivan; Tomanović, Nada; Cutovic, Milisav; Dokic, Ljubisa; Simonović, Jasmina; Svirtlih, Neda

doi:10.2298/vsp0609819d

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Regarding the association between the number of α-SMA HSCs and the grade of necro-inflammation, our study did not find any statistically significant correlation between these two variables, which is in accordance to results reported by other published papers [33,76,78,80,93,94]. This aspect could be explained by the fact that HSCs were already activated by HCV, even in the absence of severe necro-inflammatory activity [75,80,99].…”

Section: Discussionsupporting

confidence: 91%

Activated Hepatic Stellate Cells (Ito Cells) - Marker of Advanced Fibrosis in Chronic Viral Hepatitis C: A Pilot Study

Sufleţel

Melincovici

Orășan

et al. 2023

JGLD

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Background and Aims: The aim of this study is to determine whether activated hepatic stellate cells (HSCs) may represent a prognostic marker of progressive liver fibrosis in chronic viral hepatitis C (VHC) before antiviral therapy. The possible correlation between HSCs immunohistochemical features, histopathological aspects and clinical data before therapy were also studied. Methods: This retrospective pilot study was conducted on 27 liver biopsies from VHC patients before antiviral therapy. HSCs’s immunohistochemical analysis used the antibodies alpha-smooth muscle actin (α-SMA), glial fibrillary acidic protein (GFAP) and vinculin. We correlated immunopositive HSCs with HCV load, liver stiffness (LS), fibrosis stage and necro-inflammatory degree before treatment. Also, we assessed the association between liver fibrosis after therapy, the sustained virological response at 12 weeks after therapy (SVR 12) and the type of therapy. Results: HSCs were increased in VHC patients compared to controls, mainly in the intermediate and periportal lobular regions. α-SMA and vinculin HSCs correlated positively with fibrosis stage (p=0.044), (p=0.028). Furthermore, α-SMA and vinculin HSCs were associated with LS (p=0.027), (p=0.002) and viral load (p=0.021), (p=0.006), but not with necro-inflammation degree. GFAP HSCs inversely correlated with fibrosis stage (r= -0.475), LS (r= -0.422) and HCV load (r= -0.517), but positively with necro-inflammation degree (p=0.038). Liver fibrosis post therapy correlated positively with SVR12 (p<0.001) and the type of therapy (p=0.006) and SVR12 correlated positively with treatment’s type (p=0.002). Conclusions: Activated HSCs may represent a marker of increased liver fibrosis in VHC. Different immunohistochemical markers can detect various HSCs subpopulations involved in the evolution of VHC and liver fibrosis.

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Section: Discussionsupporting

confidence: 91%

Activated Hepatic Stellate Cells (Ito Cells) - Marker of Advanced Fibrosis in Chronic Viral Hepatitis C: A Pilot Study

Sufleţel

Melincovici

Orășan

et al. 2023

JGLD

View full text Add to dashboard Cite

show abstract

“…The dominance of genotype 3 is consistent with the pattern of HCV genotypes distribution among risk groups in Western Europe, as in Serbia [12][13][14] . A recent study conducted in Serbia confirmed that the patients infected with HCV genotype 1b had more frequently moderate or severe necroinflammatory activity of the disease, and a significantly higher grading score as compared with other genotypes 16 . A recent study conducted in Serbia confirmed that the patients infected with HCV genotype 1b had more frequently moderate or severe necroinflammatory activity of the disease, and a significantly higher grading score as compared with other genotypes 16 .…”

Section: Discussionmentioning

confidence: 99%