Histopathology of autoimmune bullous dermatoses: what's new?

Tekin, Burak; Johnson, Emma F.; Wieland, C; Gibson, Lawrence E.; Camilleri, Michael; Kalaaji, Amer N.; Comfere, Nneka I.; Peters, Margot S.; Lehman, Julia S.

doi:10.1016/j.humpath.2022.06.021

Cited by 3 publications

(2 citation statements)

References 129 publications

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“…7 Histologically, BSLE is characterized by a subepithelial detachment accompanied by a superior dermal neutrophilic infiltrate and papillary micro-abscesses, as presented in this case. 2 Due to the biopsy taken from the patient, it was possible to reach an accurate diagnosis and provide the appropriate treatment, so we emphasize this methodology to achieve better management. Likewise, in the direct immunofluorescence a linear deposition of IgG was found in the area of the basal membrane that was useful to differentiate the diagnosis from DH and LABD.…”

Section: Discussionmentioning

confidence: 99%

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Clinical presentation of bullous systemic lupus erythematosus in a pediatric patient: a case report

Tostado,

Parra,

Ramirez

et al. 2023

Int J Res Dermatol

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Bullous systemic lupus erythematosus (BSLE) is a rare blistering eruption that can occur in patients with systemic lupus erythematosus. Although 59 to 85% of patients will have skin manifestations, less than 5% will develop the bullous disease, which is even rarer (1%) in the pediatric population. We present the case of a 16-year-old female patient in whom a diagnosis of BSLE was made through clinical presentation, histological study by biopsy, and direct immunofluorescence. Due to the low incidence of cases reported in pediatric patients, it is possible that the diagnosis may not be made immediately, which is why we emphasize the importance of obtaining an accurate diagnosis and providing timely treatment.

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Section: Discussionmentioning

confidence: 99%

“…Histologically BSLE is characterized by a subepithelial detachment accompanied by a superior dermal neutrophilic infiltrate and papillary microabscesses. 2…”

Section: Introductionmentioning

confidence: 99%

Clinical presentation of bullous systemic lupus erythematosus in a pediatric patient: a case report

Tostado,

Parra,

Ramirez

et al. 2023

Int J Res Dermatol

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Lichen Planus: What is New in Diagnosis and Treatment?

Tekin,

Xie,

Lehman

2024

Am J Clin Dermatol

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Metronidazole-induced linear immunoglobulin A disease in a patient suffering from ulcerative colitis: a case report and focused review of the literature

Buffon,

Parietti,

Carugno

et al. 2023

Dermatol Reports

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Linear immunoglobulin (Ig) A disease (LAD) is a rare autoimmune blistering dermatosis caused by linear deposition of IgA1 along the dermoepidermal junction of skin and mucosae. It can affect both children and adults. Although idiopathic in most cases, it can also be associated with infections, malignancies, or drug administration. Among medications, antibiotics are most commonly responsible, particularly vancomycin. We report the case of a 51-year-old female patient who developed mucocutaneous LAD after oral metronidazole administration, which was confirmed by histopathological examination and direct immunofluorescence of one of the bullous lesions. Lesions rapidly cleared after metronidazole discontinuation and a short course of oral methylprednisolone and dapsone. To our knowledge, this is the third reported case of metronidazole-induced LAD, and the first in which metronidazole was not administered in combination with other antibiotics such as ceftriaxone.

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Histopathology of autoimmune bullous dermatoses: what's new?

Cited by 3 publications

References 129 publications

Clinical presentation of bullous systemic lupus erythematosus in a pediatric patient: a case report

Clinical presentation of bullous systemic lupus erythematosus in a pediatric patient: a case report

Lichen Planus: What is New in Diagnosis and Treatment?

Metronidazole-induced linear immunoglobulin A disease in a patient suffering from ulcerative colitis: a case report and focused review of the literature

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