Histopathology and histomorphometric investigation of bisphenol a and nonylphenol on the male rat reproductive system

Kazemi, Sohrab; Feizi, Farideh; Aghapour, Fahimaeh; Joorsaraee, Gholam Ali; Moghadamnia, Ali Akbar

doi:10.4103/1947-2714.183012

Cited by 48 publications

(11 citation statements)

References 23 publications

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“…BPA chemical toxic effects are confirmed in adult rats, showing reduced testes and prostate gland weights, decreased serum testosterone levels, reduced diameter and thickness of seminiferous tubules, significantly thinner seminiferous epithelium and subsequent abnormal spermatogenesis in term of decreased sperm count and motility [25]. The authors postulate that in rats exposed to BPA there is a loss of structural integration in the gonadal compartment with the formation of gaps between germinal cells, as demonstrated previously in in vitro studies [32, 33].…”

Section: Bpa and Male Reproduction In Animal Modelsmentioning

confidence: 58%

“Bisphenol a: an emerging threat to male fertility”

Cariati

D’Uonno

Borrillo

et al. 2019

Reprod Biol Endocrinol

130

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BackgroundAmong the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic action appears to mainly affect the male reproductive system, directly impacting male fertility.MainThe purpose of this review is to investigate current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action.ConclusionA clear understanding of BPA action mechanisms, as well as the presumed risks deriving from its exposure, is becoming crucial to preserve male fertility. The development and validation of methodologies to detect BPA toxic effects on reproductive organs can provide greater awareness of the potential threat that this chemical represents.

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Section: Bpa and Male Reproduction In Animal Modelsmentioning

confidence: 58%

“Bisphenol a: an emerging threat to male fertility”

Cariati

D’Uonno

Borrillo

et al. 2019

Reprod Biol Endocrinol

130

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“…It is used in detergents, emulsifiers, and in several industries, for example in paints, pesticides, and household toiletries [7]. Studies have suggested that NP has deleterious effects on the endocrine [8], reproductive [9], immune [10], and nervous systems in animals and humans [11].…”

Section: Introductionmentioning

confidence: 99%

Hazards of Chronic Exposure to Nonylphenol: Concomitant Effect on Non-alcoholic Fatty Liver Disease in Male Albino Rats

Elsyade

Sawaf

Gaber

2021

Open Access Maced J Med Sci

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BACKGROUND: Chronic exposure to environmental endocrine disruptors like nonylphenol (NP), has been shown in previous studies to predispose to non-alcoholic fatty liver disease. METHODS: In this work, forty adult male albino rats were divided into four groups, a high sucrose-high-fat diet (HSHFD) group, a group receiving 20 μg/kg/day of NP, an NP + HSHFD group, and a control group. The rats were sacrificed on day 60 after anesthetization. RESULTS: Biochemical tests indicated that serum transaminases (alanine aminotransferase, aspartate aminotransferase) were significantly increased in the NP + HSHFD group. Lipid metabolism was most disrupted in the NP + HSHFD with a highly significant increase (p < 0.001) of serum cholesterol, triglyceride, and low-density lipoprotein cholesterol compared to other groups. Heme oxygenase 1 showed the highest expression in the NP + HSHFD group, with a highly significant difference in comparison with the other groups (p < 0.001). Histopathological studies revealed fatty changes and dilatation in the central vein in the HSHFD group. Lymphoid cell aggregates were detected in the NP group. Massive inflammation and degeneration were revealed in the NP + HSHFD group. There was also marked expression of the apoptotic protein caspase-3 in the NP + HSHFD group. CONCLUSION: In conclusion, exposure to a 20 μg/kg/day of NP induced oxidative stress leading to non-alcoholic steatohepatitis.

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“…NP has been detected in human urine samples 10 and adipose tissues 11 . Studies have suggested that NP has deleterious effects on endocrine 12 , reproductive 13 , immune 14 , and nervous 15,16 systems in animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats

Yang

et al. 2018

Sci Rep

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Exposure to environmental endocrine disruptors (EEDs) contributes to the pathogenesis of many metabolic disorders. Here, we have analyzed the effect of the EED-nonylphenol (NP) on the promotion of non-alcoholic fatty liver disease (NAFLD) in rats fed high sucrose-high fat diet (HSHFD). Fifty Sprague-Dawley rats were divided into five groups: controls fed a normal diet (C-ND); HSHFD-fed controls (C-HSHFD); and rats fed a HSHFD combined with NP at doses of 0.02 μg/kg/day (NP-L-HSHFD), 0.2 μg/kg/day (NP-M-HSHFD), and 2 μg/kg/day (NP-H-HSHFD). Subchronic exposure to NP coupled with HSHFD increased daily water and food intake (p < 0.05), hepatic echogenicity and oblique liver diameter (p < 0.05), and plasma levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, and low density lipoprotein cholesterol (p < 0.05). Combined exposure to NP and HSHFD induced macrovesicular steatosis with dilation and congestion of the central vein, liver inflammatory cell infiltration, and expression of genes regulating lipid metabolism, SREBP-1C, FAS, and Ucp2. These results demonstrate that NP aggravates NAFLD in HSHFD-treated rats by up-regulating lipogenic genes, and that HSHFD increases the toxic effects of NP. Thus subchronic NP exposure may lead to NAFLD, especially when combined with a high-sucrose/high-fat diet.

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Histopathology and histomorphometric investigation of bisphenol a and nonylphenol on the male rat reproductive system

Cited by 48 publications

References 23 publications

“Bisphenol a: an emerging threat to male fertility”

“Bisphenol a: an emerging threat to male fertility”

Hazards of Chronic Exposure to Nonylphenol: Concomitant Effect on Non-alcoholic Fatty Liver Disease in Male Albino Rats

Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats

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