Histopathology and Feline Pancreatic Lipase Immunoreactivity in Inflammatory, Hyperplastic and Neoplastic Pancreatic Diseases in Cats

Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats

“…Further studies about pancreas-specific laboratory parameters in cats with lymphomas are necessary to investigate the prevalence of pancreatic involvement. Furthermore, inflammation was also reported in numerous feline epithelial pancreatic tumors [29] and as far as serological data were available, fPLI value was increased in several cases [32]. One may conclude that increased serological pancreatic enzymes can be indicative of an acute pancreatitis.…”

Letter regarding "ACVIM consensus statement on pancreatitis in cats"

“…3,4 However, 1 of the papers cited 3 does not include any data on the LABOKLIN test while the other 4 is a German language publication with several methodological limitations which are not discussed in the ACVIM consensus statement. Furthermore, the LABOKLIN working group has reported elevated fPLI values in cats with epithelial or nonepithelial pancreatic neoplasms, 2,5 as well as comparable data for canine PLI in dogs. 6,7 These studies on PLI in tumor patients offer a much broader range of interpretation than just speculation on pancreatitis.…”

Response to letter regarding “ACVIM consensus statement on pancreatitis in cats”

“…The reference by Törner et al does provide some summary data on the analytical validation of this assay, but allows no determination of the modifications to the assay or the details of the analytical validation of the assay, as no raw data were provided. 1 The statement concerning discordance of the 1,2-o-dilauryl-racglycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) assay with serum fPLI was simply based on Cohen's kappa coefficient of 0.7 reported in the study by Oppliger et al and was appropriately cited. 5 The panel felt that no further discussion was needed as a value of 0.7 for 2 assays that supposedly measure the same analyte demonstrates discordance.…”

“…We would like to start by apologizing for not citing 1 of their papers in the consensus statement. 1 This certainly was not done with any ill intent. However, the consensus statement included 209 references and the panel had to choose which references to include.…”

“…We would like to explain our decision not to include the reference by Törner et al 1 This study investigated the association of feline pancreas‐specific lipase (fPLI) concentrations with underlying histopathology, and we felt that it underscored the existing literature with respect to pancreatitis in cats, and did not add new information. In addition, the study by Törner et al focused on fPLI concentrations in cats with neoplastic diseases of the pancreas, which are rare in cats and were not the focus of our statement.…”