Histopathologische Diagnosen nach Amputation umfangsvermehrter Zehen bei Hund und
                              Katze

Gruber-Beckmann, Barbara; Aupperle, H.; Staudacher, Marlies

doi:10.1055/s-0042-118000

Cited by 1 publication

(6 citation statements)

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“…Currently, this study represents the largest collection of canine digital lesions (n = 2912) within the existing literature. The incidence of the various lesions described herein are largely in concordance with previous studies [ 1 , 3 , 4 ] and included a wide age range (1 month to 17 years). As expected, dogs with acral neoplasms were significantly older than those with tumor-like or non-neoplastic changes.…”

Section: Discussionsupporting

confidence: 90%

“…Frequently, in order to diagnose and treat this condition, digital amputation and subsequent histologic evaluation is performed [ 1 ]. Of all of the canine digital conditions, inflammatory lesions account for 19–31.1%, while malignant neoplastic processes account for 53.5–81% [ 1 , 3 , 4 ]. Digital tumor-like lesions (mostly adnexal dysplasia and polyps) occur in 5.7 [ 4 ] to 6.4% [ 1 ] of cases.…”

Section: Introductionmentioning

confidence: 99%

“…Of all of the canine digital conditions, inflammatory lesions account for 19–31.1%, while malignant neoplastic processes account for 53.5–81% [ 1 , 3 , 4 ]. Digital tumor-like lesions (mostly adnexal dysplasia and polyps) occur in 5.7 [ 4 ] to 6.4% [ 1 ] of cases. Digital benign neoplasms include subungual keratoacanthoma (22.4%), sebaceous adenoma (7.5%), histiocytoma (4.4%), keratoma (4.4%), plasmacytoma (3.0%), and trichoblastoma (3.0%) [ 1 ] as well as hemangioma (16%) and lipoma (8%) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The second most frequent canine digital malignant neoplasia is the melanoma [ 3 ], a neoplasia originating from melanocytes [ 9 ]. This tumor has a reported prevalence of 16.2–17.3% [ 1 , 3 , 4 ] as well as an aggressive behavior [ 9 ]. Interestingly enough, there is no consensus regarding the initiating factors for this neoplasia in dogs [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although these studies report some breed predispositions, the sample size is relatively small (Wobeser et al [ 1 ]: n = 404, Gruber-Beckmann et al [ 4 ]: n = 380, Marino et al [ 3 ]: n = 117). On the other hand, recognizing tumor-resistant breeds may significantly contribute to a deeper understanding of oncogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases

Grassinger

Floren

Müller

et al. 2021

Veterinary Sciences

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Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = −2.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = −2.17), Jack Russell Terriers (log OR = −1.88), and Rhodesian Ridgebacks (log OR = −1.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or “resistance” to the development of specific acral tumors and/or other sites.

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Section: Discussionsupporting

confidence: 90%