Histopathologie nach Implantation von Lidgewichten

Schrom, T.; Taege, C.; Wolf, Georg; Reinhardt, Ad.; Scherer, Hans

doi:10.1007/s00106-005-1346-7

Cited by 9 publications

(12 citation statements)

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“…In contrast, two studies describing chronic inflammatory reactions to gold in humans found a clear predominance of either T cells or B cells. 12,25 An interesting observation in the present study was the tendency of T cells and B cells to occupy separate regions in the lymphocytic infiltrates, resulting in some resemblance to lymphoid follicles. The de novo formation of lymphoid follicles at sites of chronic inflammation has been described 17,27,29,31 and has been reported in lesions associated with inflammation caused by metallic gold in humans.…”

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confidence: 58%

“…This is in accordance with studies involving gold and high gold alloys in humans, rats, and dogs in which granulomatous reactions are rarely reported. 1,25,26,30 Conversely, nonprecious metals and alloys of low gold content are reported to cause granulomatous inflammation in guinea pigs and rats. 2,16 T lymphocytes and B lymphocytes were both prominent in the inflammatory infiltrates in the dogs.…”

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confidence: 99%

“…Findings from human studies suggest that inflammatory reactions to gold implants occur in a limited number of patients; 28 yet, these human studies could be biased by the primary availability of specimens from cases where the implants had to be removed owing to complications. 25 Thus, little is known about the patients that do not have adverse clinical symptoms after implantation. In rats, the tissue reaction to gold has been reported to be not significantly different from that seen in controls.…”

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Inflammatory Response to Therapeutic Gold Bead Implantation in Canine Hip Joint Osteoarthritis

et al. 2010

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Inflammatory changes associated with periarticular pure gold bead implants were studied in dogs involved in a clinical trial investigating motor dysfunction and chronic pain owing to hip joint dysplasia and osteoarthritis. Gold beads were percutaneously implanted via a needle into different locations surrounding the greater trochanter of the femur. Nine dogs with implants were necropsied. In all examined animals, characteristic histologic lesions were observed in the tissue surrounding the gold implants-namely, a fibrous capsule composed of concentric fibroblasts intermixed with a variable number of inflammatory cells and a paucicellular innermost layer of collagen with a few fibrocyte-like cells in empty lacunae. Lymphocytes dominated the inflammatory infiltrate, with rarely observed macrophages present in close proximity to the implant site. No giant cells were observed. Immunohistochemistry showed mixed populations of lymphocytes, both CD3 positive (T cells) and CD79a positive (B cells), which in some cases formed lymphoid follicles. Diffuse inflammatory changes were present to a minor extent in the perimysium and surrounding fascia. The inflammation observed in dogs is similar to that observed with gold implants in humans. It is possible that the clinically beneficial effect of gold beads for chronic osteoarthritis depends on sustained localized inflammation with localized release of soluble mediators. The encapsulation of the implant by a paucicellular and poorly vascularized fibrous capsule may help prevent an exaggerated inflammatory reaction by sequestering the gold bead from the surrounding tissue. Keywords B cells, dogs, gold implants, immunohistochemistry, inflammation, osteoarthritis, T cellsThe parenteral therapeutic use of gold salts (chrysotherapy) is well known in human medicine and has been used in cases of rheumatoid arthritis. 23 The mechanisms behind the anti-inflammatory effect of monovalent gold salts and its metabolites, such as Au 3þ , Au(CN) 2 -, and metallic gold, is incompletely understood.5 One proposed mechanism of action for Au þ is due to binding with thiolate and thioether ligands on proteins.5 This is thought to inhibit presentation of complexed antigen to T cells, activity of certain transcription factors, and enzymes such as protein tyrosine phosphatase in T cells, protein kinase C in neutrophils and T cells, and proteins important for B cell differentiation. Au(CN) 2 -is an effective inhibitor of the respiratory burst of neutrophils and monocytes; it also inhibits the proliferation of lymphocytes. 5A more recent therapeutic application of gold is the implantation of gold beads directly into a painful anatomic region, such as the periarticular tissue of arthritic joints. This technique is derived from acupuncture and has been used in veterinary medicine for the past decade, largely as a treatment in canine hip dysplasia.10 A recent double-blind, placebocontrolled clinical trial performed by Jaeger et al showed that the performance of dogs with hip joint osteoarthritis s...

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Inflammatory Response to Therapeutic Gold Bead Implantation in Canine Hip Joint Osteoarthritis

et al. 2010

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“…По разным данным, частота удаления (включая его замену) имплантата (по причине аллергической ре-акции на золото) составляет от 9,3 до 12%, что не-сколько превышает наши данные (5,7%) [12,15].…”

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Gold weight implants for lagophthalmos correction in chronic facial nerve paralysis (late results)

et al. 2016

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“…Berghaus et al (2003) performed a clinical follow up of 30 platinum chain implants reporting pseudo capsule formation being seen regularly, however, no cases of foreign body reaction or hypersensitivity noted . Schrom et al (2006) reported histopathological evidence of inflammatory infiltration (mixed lymphocytic type) occurring at rates of 12.5% found incidentally following explanation of platinum chain implants following recovery of function or migration …”

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Delayed necrobiotic granulomatous reaction following removal of eyelid platinum chain

Ryan

Juniat²,

James

et al. 2019

Clinical Exper Ophthalmology

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Histopathologie nach Implantation von Lidgewichten

Abstract: Both gold and platinum are suitable for treating lagophthalmos, however, platinum has a higher density and better biocompatibility than gold.

Cited by 9 publications

References 31 publications

Inflammatory Response to Therapeutic Gold Bead Implantation in Canine Hip Joint Osteoarthritis

Inflammatory Response to Therapeutic Gold Bead Implantation in Canine Hip Joint Osteoarthritis

Gold weight implants for lagophthalmos correction in chronic facial nerve paralysis (late results)

Delayed necrobiotic granulomatous reaction following removal of eyelid platinum chain

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