Histopathological Variants of Neurofibroma

Megahed, Mosaad

doi:10.1097/00000372-199410000-00003

Cited by 106 publications

(121 citation statements)

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“…Several histologic variants have been recognized over time, including classic, plexiform, cellular, epithelioid, myxoid, hyalinized, pacinian, pigmented, and granular cell variant [3][4][5]. In addition, some cases of neurofibroma with epithelial, rhabdomyomatous and lipomatous differentiation, or dendritic cells with pseudorosette formation have also been described [1,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases

et al. 2009

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Multinucleated floret-like giant cells (MNFGCs), similar to those commonly observed in pleomorphic lipoma and giant cell fibroblastoma, have been occasionally reported in gynecomastia and neurofibromas from patients affected by neurofibromatosis type 1 (NF1). Accordingly, it has been suggested that their detection, especially in an otherwise typical neurofibroma, could be a morphological clue to diagnosis of NF1. The aim of the present study was the identification of MNFGCs in a large series (94 cases) of sporadic and NF1-associated neurofibromas, to assess if their presence may indeed be a morphological marker of NF1. Numerous MNFGCs, namely, those that were easily apparent at low magnification (x50 and x100), were identified only in 5.3% of cases. In 18.1% of cases, a low number of these cells could be observed but only after a careful search, especially at higher magnification (x200 and x400). Immunohistochemically, all MNFGCs were stained with vimentin and CD34, but not with S-100 protein. Interestingly, there was no statistically significant correlation between MNFGCs (presence or absence) and NF1 (p = 0.73), gender (p = 0.59), age (p = 0.43), and site of tumor (cutaneous vs deep-seated soft tissue; p = 0.27). Our clinicopathologic findings suggest that MNFGCs in an otherwise typical neurofibroma are not a reliable marker of NF1, likely representing a morphological reactive change of the indigenous dermal or endoneurial fibroblasts or dendritic cells in response to unknown microenvironmental stimuli.

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Section: Introductionmentioning

confidence: 99%

Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases

et al. 2009

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“…NFs are composed of S-100-positive Schwann cells, perineurial-like cells positive for epithelial membrane antigen and negative for S-100, peripheral nerve fibroblasts positive for factor XIIIa and negative for CD34 and S-100, endoneurial dendritic cells positive for CD34 and negative for S-100, mast cells, and a variable number of axons. [8][9][10] Histologic variants include classical, myxoid, cellular, hyalinized, plexiform, epithelioid, diffuse, Pacinian, pigmented, atypical, granular cell, and dendritic cell NF with pseudorosettes. 8,11 However, little has been reported regarding a rare histologic feature: NF with FMGCs.…”

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confidence: 99%

“…[8][9][10] Histologic variants include classical, myxoid, cellular, hyalinized, plexiform, epithelioid, diffuse, Pacinian, pigmented, atypical, granular cell, and dendritic cell NF with pseudorosettes. 8,11 However, little has been reported regarding a rare histologic feature: NF with FMGCs. To the best of my knowledge, after Magro et al 12 and Shaktawat and Golka, 13 this case represents the third described case of FMGCs in a NF.…”

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confidence: 99%

Floret-like Multinucleated Giant Cells in a Neurofibromatosis Type 1-Associated Neurofibroma

Swick

2008

The American Journal of Dermatopathology

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I report herein a case of floret-like multinucleated giant cells (FMGCs) in a neurofibroma (NF) from a patient with neurofibromatosis type 1 (NF1). CD34-positive FMGCs have been described in 2 prior cases of cutaneous NF and in gynecomastia from patients with NF1. In the case of NFs with FMGCs, these CD34-positive cells may represent endoneurial dendritic cells distinct from both fibroblasts and Schwann cells and do not represent degenerative or malignant change. However, the exact origin of these cells is debatable. I encourage others to observe for the presence of CD34-positive FMGCs in NFs to determine whether they are an incidental finding or are specific to NFs in patients with NF1.

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“…There are several clinical subtypes in neuro- fibroma, such as localized, diffuse, and plexiform variants 1 . Histopathologically, there are several variants including cellular, myxoid, collagenous, hyalinized, epithelioid, pigmented, granular cell, pacinian, atypical, xanthomatized, with epithelial or rhabdomyxomatous differentiation, dendritic cell with pseudorosettes, and lipomatous neurofibroma [2][3][4][10][11][12] . Eccrine hidrocystoma was first described in 1893 by Robinson 13 .…”

Section: Discussionmentioning

confidence: 99%