Histopathological variability in 'standardised' spinal cord trauma.

Koenig, G; Dohrmann, George J.

doi:10.1136/jnnp.40.12.1203

Cited by 23 publications

(9 citation statements)

References 16 publications

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“…The histopathological aspects of the lesions produced by compression with the subdural balloon are similar to those described in most experimental spinal cord injury models (Wallace et al, 1990;Khan et al, 1985;Black et al, 1986Black et al, , 1988Noble and Wrathall, 1989;Koenig and Dohrmann, 1977;Bresnahan et al, 1991) and in human pathology (Hughes, 1978(Hughes, , 1984(Hughes, , 1988. In particular, the hemorrhagic necrosis with axon and myelin fragmentation, infiltration by polymorphs and foamy Three days after a knife-section of the spinal cord.…”

Section: Discussionmentioning

confidence: 71%

Experimental acute traumatic injury of the adult rat spinal cord by a subdural inflatable balloon: Methodology, behavioral analysis, and histopathology

Martin

Schoenen

Delrée

et al. 1992

J of Neuroscience Research

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We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit.

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Section: Discussionmentioning

confidence: 71%

Experimental acute traumatic injury of the adult rat spinal cord by a subdural inflatable balloon: Methodology, behavioral analysis, and histopathology

Martin

Schoenen

Delrée

et al. 1992

J of Neuroscience Research

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“…1,2 Hence, the importance of identifying novel pathomechanisms, possibly extramedullary events like spinal subarachnoid bleeding (SSB), that could become targets for new therapeutic strategies. SSB occurs after clinical 3 and experimental 4,5 traumatic SCI.…”

Section: Introductionmentioning

confidence: 99%

Characterization of spinal subarachnoid bleeding associated to graded traumatic spinal cord injury in the rat

et al. 2014

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Study design: Observational study in rats subjected to traumatic spinal cord injury (SCI). Objectives: To describe the features of spinal subarachnoid bleeding (SSB) occurring after graded SCI. SSB after SCI has been reported previously, but has not been studied systematically despite the fact that cerebral subarachnoid bleeding often produces severe neurological damage. Setting: Mexico. Methods: Anesthetized rats were subjected to mild or severe spinal cord contusion at T9. Occurrence, size, progression and location of SSB were characterized morphologically and scored from T7-T12 at 1 h and 1, 3 and 7 days post injury. Besides, contusions were videotaped to visualize bleeding at the moment of impact. Results: SSB started immediately after contusion (severe or mild) and decreased gradually over time. For all vertebral segments, at all time points examined by histology, 48% of areas scored after severe contusion showed bleeding: 25% minor, 17% moderate and 6% major. After mild contusion, only 15% showed bleeding: 13 minor and 2% moderate. Maximum bleeding occurred early after injury in dorsal area of the epicenter in 100% of severe contusions (6% minor, 38 moderate and 56% major), and in 69% of mild contusions (63 minor and 6% moderate). Conclusion: Here, we detail SSB patterns occurring after graded SCI. Further studies are warranted to elucidate the possible role extramedullary events, such as SSB, in the pathophysiology of SCI that might encourage the development of new strategies for its management.

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“…Vor allem Ratten [6,9,15], Katzen [11,18] der ein intravençs verabreichter Farbstoff, mittels auf das Rü-ckenmark strahlenden Laserlichts, Sauerstoff freisetzt, der die Gefäße arrodiert und zu einer Gefäßokklusion führt. Diese Lä-sionen sind allerdings nicht Folge eines kompressionsbedingten Traumas, sondern kçnnen die Folge einer thrombotisch bedingten Ischämie [10] sein.…”

Section: Operationstechnikunclassified

“…Die Grçße der induzierten Läsion variiert bei allen Verfahren stark. Dies liegt beim "Weight-Drop"-Modell auch an der fehlerhaften Annahme, das Produkt aus Fallhçhe und Fallgewicht sei ein Maß für die Schwere der Läsion [11]. Alle Verfahren -außer der photochemisch induzierten Läsion -erfordern eine Laminektomie, die die physiologischen Vorgänge in dem umgebenden Gewebe verändert [12].…”

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Hat die MRT in der Frühphase des spinalen Traumas klinische Relevanz? Eine experimentelle Studie

Freund²

2007

Fortschr Röntgenstr

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Histopathological variability in 'standardised' spinal cord trauma.

Cited by 23 publications

References 16 publications

Experimental acute traumatic injury of the adult rat spinal cord by a subdural inflatable balloon: Methodology, behavioral analysis, and histopathology

Experimental acute traumatic injury of the adult rat spinal cord by a subdural inflatable balloon: Methodology, behavioral analysis, and histopathology

Characterization of spinal subarachnoid bleeding associated to graded traumatic spinal cord injury in the rat

Hat die MRT in der Frühphase des spinalen Traumas klinische Relevanz? Eine experimentelle Studie

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