Histopathological Types of Operable  Early Breast Cancer in the Elderly:  Is there a Special Pattern?  – a Retrospective, Multicentre Study

Al‐Zawi, Abdalla Saad Abdalla; Adamczyk, Beata; Wejman-Matela, Anna; Sathananthan, Sharlini

doi:10.5603/rj.2018.0002

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Well-differentiated (G1) carcinomas were diagnosed more often in patients 80+ compared to the control group, while poorly differentiated (G3) carcinomas were diagnosed in the < 80 group, but the difference was not significant. This observation is consistent with data reported in the literature [6,[21][22][23]. However, some investigators have shown significant differences in tumor differentiation, suggesting a more favorable biology of breast cancer in the elderly [24,25].…”

Section: Discussionsupporting

confidence: 92%

“…Similar relationships (3 times higher percentage of deaths than incidence) were observed in the male population, with 23 occurrences at age ≥ 80 (15.4% of total incidence) and 36 deaths (43.3% of breast cancer deaths). It is believed that breast cancers in older women have a milder course, grow more slowly, and are more often of a favorable histopathological type than in younger people [6]. This may suggest potential for a less aggressive treatment in this group of patients.…”

Section: Introductionmentioning

confidence: 99%

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Is the biology of breast cancer different in patients ≥ 80 years old?

Hudała-Klecha,

Zając,

Siedlaczek

et al. 2023

Oncol Clin Pract

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Is the biology of breast cancer different in patients ≥ 80 years old?

Hudała-Klecha,

Zając,

Siedlaczek

et al. 2023

Oncol Clin Pract

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“…Breast cancers detected with screening mammography are less likely to metastasize to lymph nodes and more likely to be treated with breast conservation treatment without chemotherapy compared to those women who declined screening [ 14 , 26 ]. In our study, individuals that underwent screening mammograms were more likely to have stage 0 or early staged breast cancers and estrogen and luminal A hormone expression which are considered favorable characteristics [ 26 ]. Interestingly, epidemiology studies have reported that triple-negative breast cancers are more common in women of African ancestry in comparison to others ethnic groups [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in the Elderly: An Observational Study Investigating Compliance of Screening Mammography in an Underserved Community

et al. 2021

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Background:The incidence of breast cancer increases with age. Individuals living in higher socioeconomic communities also have higher incidence secondary to early detection of breast cancer from increased accessibility to mammograms. This retrospective study studied the percentage of new breast cancer cases in the elderly between 2010 and 2019, and investigated the compliance of screening mammography in some of the medically underserved suburbs of southern Chicago. Methods:The parameters used to power this study include "age greater than 70" and "2010 to present" at the time the study was first initiated. The final data set contained 381 electronic health records (EMRs) that met the parameters of interest. We specifically looked at method of diagnosis, stage at diagnosis, date of last normal screening mammogram, hormone status, histology, race, and smoking history.Results: Thirty percent of the breast cancer patients diagnosed at our institution were over 70 years of age between 2010 and 2019. Of the 381 patients included in the overall sample, 45% were diagnosed with breast cancer by screening mammogram, and 52% of individuals in the 70 -75 age group were diagnosed with breast cancer by screening mammography. Only 40% of individuals in the 75+ age group were diagnosed with breast cancer by screening mammogram (P = 0.0234). Furthermore, in the overall sample, 63% had a normal screening mammogram at some time prior to their breast cancer diagnosis. In the 70 -75 age group, 76% had a normal screening mammogram at some time prior to their breast cancer diagnosis. In the 75+ age group, only 54% had a normal screening mammogram at some time prior to their breast cancer diagnosis (P < 0.0001). Individuals in both age groups were more likely to have early-stage breast cancers and luminal A hormone expression.Conclusions: Decreased compliance to screening mammography is observed in the elderly living in underserved communities. Since the elderly are underrepresented in research, organizations do not have sufficient information to recommend screening mammography in the elderly. With increasing life expectancy, observational studies have demonstrated a mortality benefit with screening mammography by early detection of breast cancer, favorable breast cancer characteristics and potentially higher cure rates. Socioeconomic factors also affect screening compliance and likely influenced the results of our study. Future studies should investigate how individual factors influence screening mammography compliance in the elderly in underserved communities.

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Histopathological Types of Operable Early Breast Cancer in the Elderly: Is there a Special Pattern? – a Retrospective, Multicentre Study

Abstract: Introduction: The aim of this study was to determine the pattern of histopathological types of breast cancer in

Cited by 2 publications

References 18 publications

Is the biology of breast cancer different in patients ≥ 80 years old?

Is the biology of breast cancer different in patients ≥ 80 years old?

Breast Cancer in the Elderly: An Observational Study Investigating Compliance of Screening Mammography in an Underserved Community

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