Histopathological trabecular meshwork remodeling after cataract surgery detected with an advanced image analyzer

Zoroquiaín, Pablo; Mastromonaco, Christina; Balaszi, Matthew; Lasiste, Jade; Aldrees, Sultan; Saheb, Nabil; Burnier, Miguel N.

doi:10.1016/j.jcrs.2017.09.034

Cited by 7 publications

(7 citation statements)

References 16 publications

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“…This suggests another mechanism alongside the ACA opening after phacoemulsification and IOL implantation. One such factor could be trabecular meshwork remodeling and ciliary body fibrosis after cataract surgery 34 .…”

Section: Discussionmentioning

confidence: 99%

Changes in ocular morphology after cataract surgery in open angle glaucoma patients

Pakulienė

Kuzmienė

Siesky

et al. 2021

Sci Rep

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The purpose of this study was to evaluate intraocular pressure (IOP) pre- and postoperatively, together with anterior chamber angle (ACA) parameters and biometrical results in cataract patients with or without open angle glaucoma (OAG). The prospective observational case–control study included 15 eyes with cataract and OAG in the glaucoma group and 25 eyes with only cataract in control group. Examination included full ophthalmic evaluation, IOP, ocular biometry and anterior segment optical coherence tomography measuring ACA pre- and 6 months postoperatively. OAG patients had a larger absolute IOP reduction compared to control group. Anterior chamber depth (ACD) and ACA width significantly increased in both groups. The OAG group had a tendency of narrower ACA preoperatively, but overall ACA parameters did not differ in either group pre- and postoperatively. The ACD change after surgery correlated with ACA parameters in the control group, but not in OAG group. Axial length was shorter postoperatively in the control group, but remained similar in the OAG group. Absolute IOP reduction was more pronounced in cataract patients with OAG than in cataract patients without glaucoma. ACD and ACA postoperatively increased in both groups and AL shortening was observed in non-OAG in cataract group.

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Section: Discussionmentioning

confidence: 99%

Changes in ocular morphology after cataract surgery in open angle glaucoma patients

Pakulienė

Kuzmienė

Siesky

et al. 2021

Sci Rep

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“…21 Although the impact of phacoemulsification on IOP mechanisms related to these changes are universally accepted in patients with closed-angle glaucoma, [15][16][17] several theories have been given regarding the post-phacoemulsification IOP reduction in OAG eyes: (1) the increase in the anterior chamber volume (2) the changes of the ACA anatomy (3) remodeling of the endothelium of the trabecular meshwork and (4) the difference in thickness between the phakic lens and the PCIOL and its impact on the ciliary body and the ciliary processes position. 2,19,22 Bearing these statements in mind -as well as the fact that an elevated IOP is associated with the progression of glaucomait can be assumed that phacoemulsification surgery could be considered as an early form of surgical glaucoma treatment. This is especially true in the case of patients with OAG eyes, 14,18 despite the fact that on a macroscopic level the anterior chamber architecture of eyes with OAG is the same as that belonging to normotensive eyes.…”

Section: Introductionmentioning

confidence: 99%

“…This is especially true in the case of patients with OAG eyes, 14,18 despite the fact that on a macroscopic level the anterior chamber architecture of eyes with OAG is the same as that belonging to normotensive eyes. 19,22,23 On the other hand, less information in the literature was published regarding the post-cataract anatomical changes in OAG patients, especially compared to normotensive eyes.…”

Section: Introductionmentioning

confidence: 99%

“…Although the impact of phacoemulsification on IOP mechanisms related to these changes are universally accepted in patients with closed-angle glaucoma, 15–17 several theories have been given regarding the post-phacoemulsification IOP reduction in OAG eyes: (1) the increase in the anterior chamber volume (2) the changes of the ACA anatomy (3) remodeling of the endothelium of the trabecular meshwork and (4) the difference in thickness between the phakic lens and the PCIOL and its impact on the ciliary body and the ciliary processes position. 2 , 19 , 22 …”

Section: Introductionmentioning

confidence: 99%

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Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients

Xirou¹,

Xirou²,

Siganos³

et al. 2023

OPTH

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The aim of this study was to evaluate and compare the changes in Intraocular Pressure (IOP) and other ocular parameters: the Anterior Chamber Angle (ACA), Anterior Chamber Volume (ACV), and Anterior Chamber Depth (ACD) during phacoemulsification surgery in Greek patients with normotensive eyes and those with well-controlled Open-Angle Glaucoma (OAG). Additionally, parameters such as the Corneal Thickness (CCT), Axial Length (AL), Central Macular Thickness (CMT), and Retinal Nerve Fibre Layer (RNFL) were also examined. Patients and Methods: This was a prospective observational case-control study that included 50 phakic eyes, 25 normotensive (Group 1), and 25 with OAG: 15 Primary Open-Angle Glaucoma (POAG) and 10 Exfoliation Glaucoma (EXG) (Group 2). Ophthalmic assessment included IOP measurements, ocular biometry, and anterior and posterior segment optical coherence tomography evaluation of the aforementioned ocular parameters, prior and 6 months after phacoemulsification surgery. Results: At the 6 months post-operative review, a greater IOP reduction was recorded in eyes with OAG, in comparison to normotensive ones (5.3mmHg and 1.6 mmHg respectively). In addition, a significant but similar increase was recorded in the values of the ACA, ACV, and ACD of both groups between the pre-and the post-op period. Furthermore, the CCT and AL values remained unaltered. Finally, there was a non-statistically significant change in the mean CMT and the mean average RNFL of both groups. Conclusion:Eyes with OAG tend to undergo a greater reduction in IOP post-phacoemulsification surgery, in comparison to normotensive eyes. This reduction may not be solely attributed to ocular anatomical changes after phacoemulsification surgery but may also be due to the remodeling of the trabecular meshwork and the ciliary body. This may be especially true in the case of OAG eyes, which already start off with a compromised trabecular endothelium prior to surgery.

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“…Open-angle glaucoma in nanophthalmos also warrants investigation as even after the anterior chamber is deepened [ 5 ] and drainage is improved [ 10 ] by cataract surgery, the incidence of postoperative elevated IOP is still higher in these eyes than in normal eyes (33% [ 11 ] vs. 0.2% [ 12 ], respectively). Schlemm’s canal (SC) and the trabecular meshwork (TM) constitute the most important aqueous humor outflow pathway of the eyes, and pathological changes at these sites are closely associated with open-angle glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Morphological features of anterior segment: factors influencing intraocular pressure after cataract surgery in nanophthalmos

Lü

et al. 2020

Eye and Vis

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Purpose To investigate the anterior segment in nanophthalmic eyes and their association with intraocular pressure after cataract surgery. Methods Thirty-two nanophthalmic eyes (axial length [AL] < 18.5 mm) in 18 patients and 35 normal eyes (21 ≤ AL ≤ 24.5 mm) in 35 controls who had undergone uneventful cataract surgery were included. Swept-source optical coherence tomography was used to compare the anterior segment structures between the two groups. The associations between the anterior segment characteristics of nanophthalmic eyes and postoperative intraocular pressure (IOP) were also investigated. Results The IOP-lowering effect of cataract surgery was remarkably insufficient in nanophthalmic eyes. Peripheral anterior synechiae (PAS) were observed in 56% (18/32) of nanophthalmic eyes, and a characteristic boomerang-shaped iris was observed in 28% (9/32). The anterior surface of the iris seemed “smoother” in nanophthalmic eyes than in normal eyes. Schlemm’s canal (SC) diameter, SC area, trabecular meshwork (TM) thickness, TM width, and TM area were generally smaller in the nanophthalmic eyes. Younger age, higher preoperative IOP, broader PAS, and smaller SC area were main contributors to higher postoperative IOP. AL and SC diameter may also be of great importance in IOP prediction in patients without glaucoma surgery and PAS. Conclusions The morphological features of the anterior segment in nanophthalmic eyes are significantly different from those of normal eyes. Influencing factors such as age, AL, preoperative IOP, extent of PAS, SC and TM size could all be prognostic for IOP after cataract surgery in nanophthalmic eyes. Trial registration ClinicalTrails.gov, Trial registration number: NCT02182921, Registered 8 July 2014.

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Histopathological trabecular meshwork remodeling after cataract surgery detected with an advanced image analyzer

Cited by 7 publications

References 16 publications

Changes in ocular morphology after cataract surgery in open angle glaucoma patients

Changes in ocular morphology after cataract surgery in open angle glaucoma patients

Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients

Morphological features of anterior segment: factors influencing intraocular pressure after cataract surgery in nanophthalmos

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