Background: The main pathogenesis of gastritis is inflammation which process can not be separated from the role of free radicals. Malondialdehyde (MDA) is a free radical biomarker and which increases in gastritis (p = 0.014; PR = 8.667;). There was a significant association between degree of neutrophil activity with high MDA level (p = 0.002; PR = 11.33;). There was a significant association between degree of atrophy with high level of MDA (p < 0.001; PR = 14;). There was a significant association between degree of intestinal metaplasia with high MDA level (p = 0.001; PR = 12.5;.Conclusion: There were significant associations between degree of lymphocyte infiltration, neutrophil activity, atrophy, and intestinal metaplasia with high level of MDA.