Histopathological studies on the cystic formation of the human urothelium.

Noda, Shinshi; Eto, Kosaku

doi:10.2739/kurumemedj.37.55

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…Furthermore, bacteria can be taken up by the urothelium and be presented to the immune system during successive filling and emptying of the bladder 83. As a result, cystic structures in the urothelial layer can occur during infections and if bacteria are not eliminated, the infection can become chronic 84…”

Section: Urothelial Structure and Function Associated With Diseasementioning

confidence: 99%

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Birder

Ruggieri

Takeda

et al. 2012

Neurourology and Urodynamics

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The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery.

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Section: Urothelial Structure and Function Associated With Diseasementioning

confidence: 99%

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Birder

Ruggieri

Takeda

et al. 2012

Neurourology and Urodynamics

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“…Muzinhaltige Zellen im Epithel der Blase werden fur das Schwein nicht nur im Falle einer Zystitis beschrieben (ZOCH, 1964;TOO et al, 1985), sondern auch bei der exsudativen Dermatitis und im Zusammenhang mit Fallen von E.-coli-Enteritis, Schweinepest und suppurativer Arthritis (MEBUS et al, 1968;BROBST et al, 1971). Auch bei Menschen, Rindern und Katzen wurde iiber ahnliche Alterationen am Ubergangsepithel oder der Lurninu propria des Harntraktes bei chronischen Iniektionen als Cystitis cystica oder Cystitis glandularis berichtet (KRAG und ALCOTT, 1957;BROBST und OLSON, 1963;ZACHARY, 1981;WALTHER et al, 1987;BARRESI und MARAFIOTI, 1990;NEW und ROBERTS, 1990;NODA und ETO, 1990). Anhand der beschriebenen Zysten lai3t sich im Vergleich mit der Lichtmikroskopie (LIEBHOLD, 1991) (KOSS, 1969;JACOBS et al, 1976JACOBS et al, , 1981HODGES et al, 1977;1978;PRICE et al, 1980;HERD und WILLIAMS, 1984…”

Section: Diskussionunclassified

Rasterelektronenmikroskopische Untersuchungen an der Harnblase von Sauen unter besonderer Berücksichtigung einer Eubacterium‐suis‐Infektion

Wendt¹,

Liebhold²,

Drommer³

1994

Journal of Veterinary Medicine, Series B

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Study of Eubacterium-suis Infection in the Bladder of Sow using ElectronmicroscopyScanning electron microscopy was performed on bladder biopsies from 20 sows with cystitis. Results were compared with those of healthy control animals. Biopsy specimens were taken from nine sows infected only with commensal bacteria (E. coli, streptococci, staphylococci) and from 11 sows, where Eubacterium suis (E. su25) was involved in urinary tract infection and had caused a haemorrhagic cystitis. Increased losses of normal superficial cells covered with microplicae could be seen depending on the degree of cystitis. Desquamation of the surface layer exposed smaller cells patterned with short microvilli. These cells were presumed to be immature intermediate cells and goblet cells. Goblet cells were found only in infected organs. The varying surface structure of epithelial cells in relation to receptor quality is important for the bacterial adherence to bladder mucosa.All examined bladders infected with E. suis showed a total loss of superficial cells. Luminal cells covered with multiple short microvilli were accompanied by cells with long pleomorphic processes. Accumulating cell necrosis was indicated by a smooth surface structure. Funnelshaped orifices between the epithelial cells were identified as excretory ducts of mucus-filled cysts, which are formed by the confluence of degenerating goblet cells.E. suis infection of the porcine bladder causes more severe alterations than infections due to other bacteria. However, debilitation of the urothelium due to previous infection is necessary to support infection of the bladder with E. suis.

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“…Infection causes primary irritation of the urothelium, and long-term chronic infection may cause the transitional epithelium to proliferate into buds, invade the lamina propria and differentiate into intestinal columnar epithelial mucin-secreting glands (cystitis glandularis) or cystic deposits (cystitis cystica) 28 . CCEG is diagnosed based on the presence of characteristic pathological phenomena, such as increases in the numbers of nest-like structures known as Brunn’s nests, secretory cyst development, and lymphocyte infiltration 29 . In this study, we established a CCEG rat model via long-term intravesicular instillation of E .…”

Section: Discussionmentioning

confidence: 99%

Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway

Zhao

Yin

et al. 2017

Sci Rep

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Cystitis cystica et glandularis (CCEG) is a chronic cystitis that causes extreme agony in affected patients. However, there are lack of effective conservative treatments. In this study, it is evident that intravesicular sodium hyaluronate (SH) therapy significantly improved the clinical symptoms of CCEG patients and ameliorated the bladder mucosal inflammation and cell proliferation characteristics of the disease. Immunohistochemical staining showed that the staining intensities of hyaluronidase (HYAL 1/2), CD44, IL-6 and phosphorylated signal transducer and activator of transcription 3 (p-Stat3) in bladder mucosal tissue were significantly increased in CCEG patients compared with control patients and that intravesicular SH treatment suppressed these protein expression. We established a CCEG rat model by treating rats with E. coli intravesicularly, and we found that HYAL 1/2 and CD44 expression levels were significantly increased in the E. coli group compared with the NC group. Activation of the IL-6/JAK2/Stat3 pathway and the expression levels of the downstream pro-apoptotic proteins Mcl-1 and Bcl-xL were also significantly increased in the E. coli group compared with the NC group. The above changes were significantly mitigated by intravesicular SH treatment. Therefore, SH may serve as an effective therapy for CCEG by inhibiting bladder mucosal inflammation and proliferation.

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Histopathological studies on the cystic formation of the human urothelium.

Cited by 9 publications

References 5 publications

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Rasterelektronenmikroskopische Untersuchungen an der Harnblase von Sauen unter besonderer Berücksichtigung einer Eubacterium‐suis‐Infektion

Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway

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