Histopathological Studies on Intra Epididymal Zinc Arginine Administration in Pre-Pubertal Dogs

Chemical Control of Fertility in Male Dogs: A Review

“…Stray dog population can be best managed by sterilizing male dogs as they have potential of impregnating large number of receptive females during the breeding season, so sterilizing number of males could conceivably decrease the number of pregnant female to the point of reversing population growth (Chaudhary et al, 2018). Surgical castration has been the only reliable and permanent method of sterilization of male animals and one English book on the art of hunting, dating back to 1575 has mentioned castration of male and female dogs (ACC&D, 2013).Vasectomy which was first performed on a dog by Cooper in 1823 (Leavesley, 1980) and vasal occlusion are other surgical procedures which can be done for sterilization of male dogs.…”

“…The authors concluded that one single intraepididymal injection of 50 mg of zinc arginine causes sterility by blocking sperm transport from the testes to the epididymides without affecting spermatogenesis and testosterone production and offers a new, safe modality for permanent male chemical sterilization. Chaudhary et al(2018) administered zinc arginine solution@ 0.2 ml into each cauda epididymis percutaneously into pre-pubertal dogs and surgically removed testis and epididymis from two animals for histopathological studies on day 10,20,30,40,50,60,70,80 and 90 respectively and reported complete degeneration of epididymal tubules, fibrous tissue presence and loss of structural details in most of the tubules on day 20 and 30 after injection. The authors concluded that single intraepididymal injection of zinc arginine causes complete necrosis of the caudaepididymal tubules in pre-pubertal dogs and it can cause an irreversible loss of fertility in dogs.…”